Lanthanide ion enhancement of interferon binding to cells

Pretreatment of purified [ 125I]-labeled human and mouse β interferons (IFN) with lanthanum chloride (LaCl 3) enhanced 20–30 fold the binding of the [ 125I]-IFNs to human A549 and mouse L cells at 0°C and also enhanced antiviral activity in homologous cells. Although lanthanides enhanced cross-speci...

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Veröffentlicht in:	Biochem. Biophys. Res. Commun.; (United States) 1986-05, Vol.137 (1), p.480-485
Hauptverfasser:	Sedmak, J.James, MacDonald, Hector S., Kushnaryov, Vladimir M.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques ANIMALS Applied sciences BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BIOCHEMICAL REACTION KINETICS BIOLOGICAL EFFECTS Cell Line CHLORIDES CHLORINE COMPOUNDS DATA DAYS LIVING RADIOISOTOPES ELECTRON CAPTURE RADIOISOTOPES Exact sciences and technology EXPERIMENTAL DATA GROWTH FACTORS HALIDES HALOGEN COMPOUNDS Humans INFORMATION INTERFERON Interferon Type I - metabolism INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES ISOTOPE APPLICATIONS ISOTOPES KINETICS LABELLED COMPOUNDS Lanthanum - pharmacology LANTHANUM CHLORIDES LANTHANUM COMPOUNDS LYMPHOKINES MAMMALS MEMBRANE PROTEINS MICE MICROORGANISMS MITOGENS NUCLEI NUMERICAL DATA ODD-EVEN NUCLEI ORGANIC COMPOUNDS Other techniques and industries PARASITES Protein Binding - drug effects PROTEINS RADIOISOTOPES RARE EARTH COMPOUNDS REACTION KINETICS RECEPTORS Receptors, Immunologic - metabolism Receptors, Interferon RESPONSE MODIFYING FACTORS RODENTS Species Specificity TRACER TECHNIQUES VERTEBRATES VIRUSES Ytterbium - pharmacology
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