Persistent infections with Sendai virus and Newcastle disease viruses
Persistent infections (Pi) were established in two host-cell systems [Madin-Darby bovine kidney (MDBK) and Madin-Darby canine kidney (MDCK)] with Sendai virus and three strains of NDV, to test the influence of different viruses and host-cell systems. Virus was recovered from the persistently infecte...
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| Veröffentlicht in: | Archives of virology 1986-01, Vol.89 (1-4), p.225-233 |
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| container_title | Archives of virology |
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| creator | LAWTON, P KARIMI, Z MANCINELLI, L SETO, J. T |
| description | Persistent infections (Pi) were established in two host-cell systems [Madin-Darby bovine kidney (MDBK) and Madin-Darby canine kidney (MDCK)] with Sendai virus and three strains of NDV, to test the influence of different viruses and host-cell systems. Virus was recovered from the persistently infected cells. An RNA- ts mutant was recovered from a Pi of MDBK cells, but no Pi could be established in MDCK cells with the three strains of NDV. Additionally, the Pi was established exclusively by a virulent strain, NDV-Milano. On the other hand, Sendai virus could establish Pi in MDBK and MDCK cell-systems. Several ts mutants were recovered from "late" passages of Pi, and from an accidental infection, a ts mutant with an altered P polypeptide. Ten other ts mutants were tested, however, the specific ts lesion could not be identified. From three Pi in MDCK cells, host range mutants (ts-f1, ts-f2, and ts-f3) were recovered. One of the mutants (ts-f1) has an altered M (matrix) protein. The host range mutants undergo a productive infection in MDBK and MDCK cells, which are nonpermissive for wild type Sendai virus. The possible significance of the results are discussed. |
| doi_str_mv | 10.1007/BF01309891 |
| format | Article |
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From three Pi in MDCK cells, host range mutants (ts-f1, ts-f2, and ts-f3) were recovered. One of the mutants (ts-f1) has an altered M (matrix) protein. The host range mutants undergo a productive infection in MDBK and MDCK cells, which are nonpermissive for wild type Sendai virus. The possible significance of the results are discussed.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/BF01309891</identifier><identifier>PMID: 3013129</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Animals ; Biological and medical sciences ; Cattle ; Cell Line ; Chick Embryo ; Culture Techniques - methods ; Electrophoresis, Polyacrylamide Gel ; Fibroblasts ; Fundamental and applied biological sciences. 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T</creatorcontrib><title>Persistent infections with Sendai virus and Newcastle disease viruses</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><description>Persistent infections (Pi) were established in two host-cell systems [Madin-Darby bovine kidney (MDBK) and Madin-Darby canine kidney (MDCK)] with Sendai virus and three strains of NDV, to test the influence of different viruses and host-cell systems. Virus was recovered from the persistently infected cells. An RNA- ts mutant was recovered from a Pi of MDBK cells, but no Pi could be established in MDCK cells with the three strains of NDV. Additionally, the Pi was established exclusively by a virulent strain, NDV-Milano. On the other hand, Sendai virus could establish Pi in MDBK and MDCK cell-systems. Several ts mutants were recovered from "late" passages of Pi, and from an accidental infection, a ts mutant with an altered P polypeptide. Ten other ts mutants were tested, however, the specific ts lesion could not be identified. From three Pi in MDCK cells, host range mutants (ts-f1, ts-f2, and ts-f3) were recovered. One of the mutants (ts-f1) has an altered M (matrix) protein. The host range mutants undergo a productive infection in MDBK and MDCK cells, which are nonpermissive for wild type Sendai virus. The possible significance of the results are discussed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cell Line</subject><subject>Chick Embryo</subject><subject>Culture Techniques - methods</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Fibroblasts</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Kidney</subject><subject>Microbiology</subject><subject>Newcastle disease virus</subject><subject>Newcastle disease virus - growth & development</subject><subject>Parainfluenza Virus 1, Human - growth & development</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Sendai virus</subject><subject>Species Specificity</subject><subject>Viral Proteins - analysis</subject><subject>Virology</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LwzAUx4Moc_64eBd6EA9CNWnSJjnq2FQYKqjnkiUvGOnamdc6_O_tWJlHTw_e9_M-8L6EnDF6zSiVN3czyjjVSrM9MmaCZ6mSWu2TMeVUpKqg6pAcIX5S2i94PiIj3h-wTI_J9AUiBmyhbpNQe7BtaGpM1qH9SF6hdiYk3yF2mJjaJU-wtgbbChIXEAzCNgM8IQfeVAinwzwm77Pp2-QhnT_fP05u56nlImtTKZSXUhYLsEroHLSTSnHQ3GV5IRRVUkkJjhmXS7EwxlEjtPK5ZwVlovD8mFxuvavYfHWAbbkMaKGqTA1Nh6UsVO_I5b9gb8uKIuM9eLUFbWwQI_hyFcPSxJ-S0XJTbvlXbg-fD9ZusQS3Q4c2-_xiyA1aU_loahtwh22eZVnOfwGrdX-V</recordid><startdate>19860101</startdate><enddate>19860101</enddate><creator>LAWTON, P</creator><creator>KARIMI, Z</creator><creator>MANCINELLI, L</creator><creator>SETO, J. 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Psychology</topic><topic>Kidney</topic><topic>Microbiology</topic><topic>Newcastle disease virus</topic><topic>Newcastle disease virus - growth & development</topic><topic>Parainfluenza Virus 1, Human - growth & development</topic><topic>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</topic><topic>Sendai virus</topic><topic>Species Specificity</topic><topic>Viral Proteins - analysis</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LAWTON, P</creatorcontrib><creatorcontrib>KARIMI, Z</creatorcontrib><creatorcontrib>MANCINELLI, L</creatorcontrib><creatorcontrib>SETO, J. 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T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent infections with Sendai virus and Newcastle disease viruses</atitle><jtitle>Archives of virology</jtitle><addtitle>Arch Virol</addtitle><date>1986-01-01</date><risdate>1986</risdate><volume>89</volume><issue>1-4</issue><spage>225</spage><epage>233</epage><pages>225-233</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>Persistent infections (Pi) were established in two host-cell systems [Madin-Darby bovine kidney (MDBK) and Madin-Darby canine kidney (MDCK)] with Sendai virus and three strains of NDV, to test the influence of different viruses and host-cell systems. Virus was recovered from the persistently infected cells. An RNA- ts mutant was recovered from a Pi of MDBK cells, but no Pi could be established in MDCK cells with the three strains of NDV. Additionally, the Pi was established exclusively by a virulent strain, NDV-Milano. On the other hand, Sendai virus could establish Pi in MDBK and MDCK cell-systems. Several ts mutants were recovered from "late" passages of Pi, and from an accidental infection, a ts mutant with an altered P polypeptide. Ten other ts mutants were tested, however, the specific ts lesion could not be identified. From three Pi in MDCK cells, host range mutants (ts-f1, ts-f2, and ts-f3) were recovered. One of the mutants (ts-f1) has an altered M (matrix) protein. The host range mutants undergo a productive infection in MDBK and MDCK cells, which are nonpermissive for wild type Sendai virus. The possible significance of the results are discussed.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>3013129</pmid><doi>10.1007/BF01309891</doi><tpages>9</tpages></addata></record> |
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| ispartof | Archives of virology, 1986-01, Vol.89 (1-4), p.225-233 |
| issn | 0304-8608 1432-8798 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Biological and medical sciences Cattle Cell Line Chick Embryo Culture Techniques - methods Electrophoresis, Polyacrylamide Gel Fibroblasts Fundamental and applied biological sciences. Psychology Kidney Microbiology Newcastle disease virus Newcastle disease virus - growth & development Parainfluenza Virus 1, Human - growth & development Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Sendai virus Species Specificity Viral Proteins - analysis Virology |
| title | Persistent infections with Sendai virus and Newcastle disease viruses |
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