Immunophenotyping of childhood acute lymphoblastic leukemia in Saudi Arabia: Second look
Geographical variations in the incidence of disease are of considerable theoretical and practical importance. It has been claimed that the distribution of acute lymphoblastic leukemia (ALL) phenotypes in Saudi Arabia is different from that recorded in the Western literature. One hundred and twelve (...
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| Veröffentlicht in: | Leukemia research 1994-12, Vol.18 (12), p.881-883 |
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| creator | Khalil, Salim H. Qari, Mohammed H. Jackson, John M. Pyle, Robert Haywood El-Solh, Hassan Al-Nasser, Abdallah |
| description | Geographical variations in the incidence of disease are of considerable theoretical and practical importance. It has been claimed that the distribution of acute lymphoblastic leukemia (ALL) phenotypes in Saudi Arabia is different from that recorded in the Western literature. One hundred and twelve (112) patients under 15 years of age, diagnosed as ALL between January 1992 and May 1994 had immunophenotypes performed on their blast cells. Common ALL (cALL) together with pre-B-ALL, formed 86.5% of the total; B-cell 3%, T-cell 6% and null cell 4.5%. These figures are not significantly different from the Western literature. A previous claim from this institution in 1990, that both null and B-cell ALL were significantly increased compared with elsewhere, is not supported by the present figures. Age and sex distribution, and FAB classification, L1 77%, L2 20% and L3 3%, were also of the same order as described elsewhere and, in particular, there was no increase in the frequency of L3 subtype. |
| doi_str_mv | 10.1016/0145-2126(94)90097-3 |
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It has been claimed that the distribution of acute lymphoblastic leukemia (ALL) phenotypes in Saudi Arabia is different from that recorded in the Western literature. One hundred and twelve (112) patients under 15 years of age, diagnosed as ALL between January 1992 and May 1994 had immunophenotypes performed on their blast cells. Common ALL (cALL) together with pre-B-ALL, formed 86.5% of the total; B-cell 3%, T-cell 6% and null cell 4.5%. These figures are not significantly different from the Western literature. A previous claim from this institution in 1990, that both null and B-cell ALL were significantly increased compared with elsewhere, is not supported by the present figures. Age and sex distribution, and FAB classification, L1 77%, L2 20% and L3 3%, were also of the same order as described elsewhere and, in particular, there was no increase in the frequency of L3 subtype.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/0145-2126(94)90097-3</identifier><identifier>PMID: 7996868</identifier><identifier>CODEN: LEREDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Antibodies, Monoclonal ; Biological and medical sciences ; Child ; Child, Preschool ; Childhood acute lymphoblastic leukemia ; Female ; Hematologic and hematopoietic diseases ; Humans ; immunophenotype ; Immunophenotyping ; Infant ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology ; Saudi Arabia</subject><ispartof>Leukemia research, 1994-12, Vol.18 (12), p.881-883</ispartof><rights>1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-8db996cfdcfd863347958fa0bfe551a0cc064ab41f22462c330a1838397305423</citedby><cites>FETCH-LOGICAL-c417t-8db996cfdcfd863347958fa0bfe551a0cc064ab41f22462c330a1838397305423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0145212694900973$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3347876$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7996868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khalil, Salim H.</creatorcontrib><creatorcontrib>Qari, Mohammed H.</creatorcontrib><creatorcontrib>Jackson, John M.</creatorcontrib><creatorcontrib>Pyle, Robert Haywood</creatorcontrib><creatorcontrib>El-Solh, Hassan</creatorcontrib><creatorcontrib>Al-Nasser, Abdallah</creatorcontrib><title>Immunophenotyping of childhood acute lymphoblastic leukemia in Saudi Arabia: Second look</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Geographical variations in the incidence of disease are of considerable theoretical and practical importance. It has been claimed that the distribution of acute lymphoblastic leukemia (ALL) phenotypes in Saudi Arabia is different from that recorded in the Western literature. One hundred and twelve (112) patients under 15 years of age, diagnosed as ALL between January 1992 and May 1994 had immunophenotypes performed on their blast cells. Common ALL (cALL) together with pre-B-ALL, formed 86.5% of the total; B-cell 3%, T-cell 6% and null cell 4.5%. These figures are not significantly different from the Western literature. A previous claim from this institution in 1990, that both null and B-cell ALL were significantly increased compared with elsewhere, is not supported by the present figures. Age and sex distribution, and FAB classification, L1 77%, L2 20% and L3 3%, were also of the same order as described elsewhere and, in particular, there was no increase in the frequency of L3 subtype.</description><subject>Adolescent</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood acute lymphoblastic leukemia</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>immunophenotype</subject><subject>Immunophenotyping</subject><subject>Infant</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology</subject><subject>Saudi Arabia</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVoSLbb_oMUdCihOTiVrO8eCiE0TSDQQ1roTciS3FUiW45kB_bf1-4ue2xgYA7zzMvMA8AZRpcYYf4ZYcqqGtf8k6IXCiElKnIEVlgKUjFJ2BuwOiCn4G0pjwghprA6ASdCKS65XIHfd1039WnY-D6N2yH0f2Bqod2E6DYpOWjsNHoYt92wSU00ZQwWRj89-S4YGHr4YCYX4FU2TTBf4IO3qXcwpvT0Dhy3Jhb_ft_X4NfNt5_Xt9X9j-9311f3laVYjJV0zXyKbd1ckhNChWKyNahpPWPYIGsRp6ahuK1rymtLCDJYEkmUIIjRmqzB-S53yOl58mXUXSjWx2h6n6aiBZdSCEleBTFnktYzuQZ0B9qcSsm-1UMOnclbjZFezOtFq160akX1P_N6yf-wz5-azrvD0l71PP-4n5tiTWyz6W0oB2x5XQo-Y193mJ-lvQSfdbHB99a7kL0dtUvh_3f8BcADnsk</recordid><startdate>19941201</startdate><enddate>19941201</enddate><creator>Khalil, Salim H.</creator><creator>Qari, Mohammed H.</creator><creator>Jackson, John M.</creator><creator>Pyle, Robert Haywood</creator><creator>El-Solh, Hassan</creator><creator>Al-Nasser, Abdallah</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19941201</creationdate><title>Immunophenotyping of childhood acute lymphoblastic leukemia in Saudi Arabia: Second look</title><author>Khalil, Salim H. ; Qari, Mohammed H. ; Jackson, John M. ; Pyle, Robert Haywood ; El-Solh, Hassan ; Al-Nasser, Abdallah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-8db996cfdcfd863347958fa0bfe551a0cc064ab41f22462c330a1838397305423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adolescent</topic><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood acute lymphoblastic leukemia</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>immunophenotype</topic><topic>Immunophenotyping</topic><topic>Infant</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology</topic><topic>Saudi Arabia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khalil, Salim H.</creatorcontrib><creatorcontrib>Qari, Mohammed H.</creatorcontrib><creatorcontrib>Jackson, John M.</creatorcontrib><creatorcontrib>Pyle, Robert Haywood</creatorcontrib><creatorcontrib>El-Solh, Hassan</creatorcontrib><creatorcontrib>Al-Nasser, Abdallah</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khalil, Salim H.</au><au>Qari, Mohammed H.</au><au>Jackson, John M.</au><au>Pyle, Robert Haywood</au><au>El-Solh, Hassan</au><au>Al-Nasser, Abdallah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunophenotyping of childhood acute lymphoblastic leukemia in Saudi Arabia: Second look</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>1994-12-01</date><risdate>1994</risdate><volume>18</volume><issue>12</issue><spage>881</spage><epage>883</epage><pages>881-883</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><coden>LEREDD</coden><abstract>Geographical variations in the incidence of disease are of considerable theoretical and practical importance. It has been claimed that the distribution of acute lymphoblastic leukemia (ALL) phenotypes in Saudi Arabia is different from that recorded in the Western literature. One hundred and twelve (112) patients under 15 years of age, diagnosed as ALL between January 1992 and May 1994 had immunophenotypes performed on their blast cells. Common ALL (cALL) together with pre-B-ALL, formed 86.5% of the total; B-cell 3%, T-cell 6% and null cell 4.5%. These figures are not significantly different from the Western literature. A previous claim from this institution in 1990, that both null and B-cell ALL were significantly increased compared with elsewhere, is not supported by the present figures. Age and sex distribution, and FAB classification, L1 77%, L2 20% and L3 3%, were also of the same order as described elsewhere and, in particular, there was no increase in the frequency of L3 subtype.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7996868</pmid><doi>10.1016/0145-2126(94)90097-3</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Antibodies, Monoclonal Biological and medical sciences Child Child, Preschool Childhood acute lymphoblastic leukemia Female Hematologic and hematopoietic diseases Humans immunophenotype Immunophenotyping Infant Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology Saudi Arabia |
| title | Immunophenotyping of childhood acute lymphoblastic leukemia in Saudi Arabia: Second look |
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