Development Of A Live, Oral, Attenuated Vaccine Against El Tor Cholera

Vibrio cholerae EI Tor strains from Peru, Bangladesh, and Bahrain were attenuated by deletion of a genetic element that encodes virulence factors and RSI. The B subunit of ctx (ctxB) was reintroduced into the recA gene of the deletion mutants, rendering them unable to recombine with exogenous geneti...

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Veröffentlicht in:	The Journal of infectious diseases 1994-12, Vol.170 (6), p.1518-1523
Hauptverfasser:	Taylor, David N., Killeen, Kevin P., Hack, Dallas C., Kenner, Julie R., Coster, Trinka S., Beattie, David T., Ezzell, John, Hyman, Tracy, Trofa, Andrew, Sjogren, Maria H., Friedlander, Arthur, Mekalanos, John J., Sadoff, Jerald C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Animals, Suckling Antibodies, Bacterial - blood Bacterial diseases Biological and medical sciences Cholera Cholera - prevention & control Cholera vaccine Cholera Vaccines - adverse effects Cholera Vaccines - genetics Cholera Vaccines - immunology Diarrhea Dosage Feces - microbiology Female Genes, Bacterial - genetics Human bacterial diseases Humans Immunoglobulin G - blood Infectious diseases Intestines - microbiology Major Articles Male Medical sciences Mice Microbial colonization Recombination, Genetic Sequence Deletion Toxins Transcriptional regulatory elements Tropical bacterial diseases Vaccination Vaccines, Attenuated - adverse effects Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Vibrio cholerae Vibrio cholerae - genetics Vibrio cholerae - growth & development Vibrio cholerae - immunology Vibrio cholerae - pathogenicity Virulence Volunteerism
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