Response to 2'-deoxycoformycin after failure of interferon-α in nonsplenectomized patients with hairy cell leukemia
Two patients with hairy cell leukemia with massive splenomegaly and severe pancytopenia were treated with recombinant alpha-A interferon (IFN-alpha-2a). There was no significant response to a trial of IFN-alpha-2a (11 and 20 weeks) with respect to blood counts or spleen size. Subsequent treatment wi...
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| Veröffentlicht in: | Blood 1986-07, Vol.68 (1), p.297-300 |
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| creator | FOON, K. A NAKANO, G. M KOLLER, C. A LONGO, D. L STEIS, R. G |
| description | Two patients with hairy cell leukemia with massive splenomegaly and severe pancytopenia were treated with recombinant alpha-A interferon (IFN-alpha-2a). There was no significant response to a trial of IFN-alpha-2a (11 and 20 weeks) with respect to blood counts or spleen size. Subsequent treatment with 2'-deoxycoformycin (dCF) for 8 consecutive weeks (4 mg/m2/wk) resulted in normalization of spleen size and a normalization of peripheral blood counts and bone marrow in one patient. The second patient demonstrated a reduction in spleen size and improved blood counts following 9 weeks of dCF therapy but eventually became refractory. This demonstrates that dCF is non-cross-resistant with interferon and confirms the efficacy of dCF in nonsplenectomized patients. |
| doi_str_mv | 10.1182/blood.V68.1.297.297 |
| format | Article |
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This demonstrates that dCF is non-cross-resistant with interferon and confirms the efficacy of dCF in nonsplenectomized patients.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V68.1.297.297</identifier><identifier>PMID: 3487358</identifier><language>eng</language><publisher>Washington, DC: The Americain Society of Hematology</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Coformycin - analogs & derivatives ; Coformycin - therapeutic use ; Female ; Humans ; Interferon Type I - therapeutic use ; Leukemia, Hairy Cell - blood ; Leukemia, Hairy Cell - drug therapy ; Leukemia, Hairy Cell - therapy ; Male ; Medical sciences ; Neuropharmacology ; Pentostatin ; Pharmacology. Drug treatments ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. 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This demonstrates that dCF is non-cross-resistant with interferon and confirms the efficacy of dCF in nonsplenectomized patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Coformycin - analogs & derivatives</subject><subject>Coformycin - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Interferon Type I - therapeutic use</subject><subject>Leukemia, Hairy Cell - blood</subject><subject>Leukemia, Hairy Cell - drug therapy</subject><subject>Leukemia, Hairy Cell - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pentostatin</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. 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G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c306t-a578732291fd174890c11783857abe2009a1901abe340554ee975c97bf3d0c0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Coformycin - analogs & derivatives</topic><topic>Coformycin - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Interferon Type I - therapeutic use</topic><topic>Leukemia, Hairy Cell - blood</topic><topic>Leukemia, Hairy Cell - drug therapy</topic><topic>Leukemia, Hairy Cell - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pentostatin</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Ribonucleosides - therapeutic use</topic><topic>Splenomegaly</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FOON, K. A</creatorcontrib><creatorcontrib>NAKANO, G. M</creatorcontrib><creatorcontrib>KOLLER, C. A</creatorcontrib><creatorcontrib>LONGO, D. L</creatorcontrib><creatorcontrib>STEIS, R. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FOON, K. A</au><au>NAKANO, G. M</au><au>KOLLER, C. A</au><au>LONGO, D. L</au><au>STEIS, R. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response to 2'-deoxycoformycin after failure of interferon-α in nonsplenectomized patients with hairy cell leukemia</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1986-07-01</date><risdate>1986</risdate><volume>68</volume><issue>1</issue><spage>297</spage><epage>300</epage><pages>297-300</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Two patients with hairy cell leukemia with massive splenomegaly and severe pancytopenia were treated with recombinant alpha-A interferon (IFN-alpha-2a). There was no significant response to a trial of IFN-alpha-2a (11 and 20 weeks) with respect to blood counts or spleen size. Subsequent treatment with 2'-deoxycoformycin (dCF) for 8 consecutive weeks (4 mg/m2/wk) resulted in normalization of spleen size and a normalization of peripheral blood counts and bone marrow in one patient. The second patient demonstrated a reduction in spleen size and improved blood counts following 9 weeks of dCF therapy but eventually became refractory. This demonstrates that dCF is non-cross-resistant with interferon and confirms the efficacy of dCF in nonsplenectomized patients.</abstract><cop>Washington, DC</cop><pub>The Americain Society of Hematology</pub><pmid>3487358</pmid><doi>10.1182/blood.V68.1.297.297</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Blood, 1986-07, Vol.68 (1), p.297-300 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Biological and medical sciences Coformycin - analogs & derivatives Coformycin - therapeutic use Female Humans Interferon Type I - therapeutic use Leukemia, Hairy Cell - blood Leukemia, Hairy Cell - drug therapy Leukemia, Hairy Cell - therapy Male Medical sciences Neuropharmacology Pentostatin Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Ribonucleosides - therapeutic use Splenomegaly |
| title | Response to 2'-deoxycoformycin after failure of interferon-α in nonsplenectomized patients with hairy cell leukemia |
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