Reduced tamoxifen accumulation is not associated with stimulated growth in tamoxifen resistance
To study tamoxifen resistance-stimulated growth, 30 female ovariectomized nude mice were implanted with tamoxifen-resistant tumors and treated with 10-1000 micrograms/day of tamoxifen citrate subcutaneously. Tamoxifen stimulated MCF-7 tumor growth in a dose-dependent manner, with tumoral tamoxifen c...
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| Veröffentlicht in: | Cancer chemotherapy and pharmacology 1994, Vol.35 (2), p.149-152 |
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| container_title | Cancer chemotherapy and pharmacology |
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| creator | MAENPAA, J WIEBE, V WURZ, G KOESTER, S EMSHOFF, V SEYMOUR, R DEGREGORIO, M |
| description | To study tamoxifen resistance-stimulated growth, 30 female ovariectomized nude mice were implanted with tamoxifen-resistant tumors and treated with 10-1000 micrograms/day of tamoxifen citrate subcutaneously. Tamoxifen stimulated MCF-7 tumor growth in a dose-dependent manner, with tumoral tamoxifen concentrations increasing proportionally to the dose (1-13 nmol/g), as measured by high-performance liquid chromatography (HPLC). Flow-cytometric analysis revealed that tamoxifen-resistant tumors had a different DNA content as compared with wild-type MCF-7 cells. In contrast to earlier results, these data suggest that tamoxifen resistance-stimulated growth is associated with increasing rather than decreasing tumoral tamoxifen concentrations. Furthermore, the observed ploidy changes in the tamoxifen-resistant tumors imply that a genetic basis may exist for the development of tamoxifen resistance. |
| doi_str_mv | 10.1007/BF00686638 |
| format | Article |
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Tamoxifen stimulated MCF-7 tumor growth in a dose-dependent manner, with tumoral tamoxifen concentrations increasing proportionally to the dose (1-13 nmol/g), as measured by high-performance liquid chromatography (HPLC). Flow-cytometric analysis revealed that tamoxifen-resistant tumors had a different DNA content as compared with wild-type MCF-7 cells. In contrast to earlier results, these data suggest that tamoxifen resistance-stimulated growth is associated with increasing rather than decreasing tumoral tamoxifen concentrations. Furthermore, the observed ploidy changes in the tamoxifen-resistant tumors imply that a genetic basis may exist for the development of tamoxifen resistance.</description><identifier>ISSN: 0344-5704</identifier><identifier>EISSN: 1432-0843</identifier><identifier>DOI: 10.1007/BF00686638</identifier><identifier>PMID: 7987992</identifier><identifier>CODEN: CCPHDZ</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Cell Division - drug effects ; Chemotherapy ; Chromatography, High Pressure Liquid ; DNA, Neoplasm - drug effects ; Dose-Response Relationship, Drug ; Drug Resistance ; Female ; Medical sciences ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Neoplasms, Experimental - drug therapy ; Neoplasms, Experimental - metabolism ; Ovariectomy ; Pharmacology. 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Tamoxifen stimulated MCF-7 tumor growth in a dose-dependent manner, with tumoral tamoxifen concentrations increasing proportionally to the dose (1-13 nmol/g), as measured by high-performance liquid chromatography (HPLC). Flow-cytometric analysis revealed that tamoxifen-resistant tumors had a different DNA content as compared with wild-type MCF-7 cells. In contrast to earlier results, these data suggest that tamoxifen resistance-stimulated growth is associated with increasing rather than decreasing tumoral tamoxifen concentrations. Furthermore, the observed ploidy changes in the tamoxifen-resistant tumors imply that a genetic basis may exist for the development of tamoxifen resistance.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Chemotherapy</subject><subject>Chromatography, High Pressure Liquid</subject><subject>DNA, Neoplasm - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Neoplasms, Experimental - metabolism</subject><subject>Ovariectomy</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Tamoxifen - chemistry</topic><topic>Tamoxifen - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAENPAA, J</creatorcontrib><creatorcontrib>WIEBE, V</creatorcontrib><creatorcontrib>WURZ, G</creatorcontrib><creatorcontrib>KOESTER, S</creatorcontrib><creatorcontrib>EMSHOFF, V</creatorcontrib><creatorcontrib>SEYMOUR, R</creatorcontrib><creatorcontrib>DEGREGORIO, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer chemotherapy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAENPAA, J</au><au>WIEBE, V</au><au>WURZ, G</au><au>KOESTER, S</au><au>EMSHOFF, V</au><au>SEYMOUR, R</au><au>DEGREGORIO, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced tamoxifen accumulation is not associated with stimulated growth in tamoxifen resistance</atitle><jtitle>Cancer chemotherapy and pharmacology</jtitle><addtitle>Cancer Chemother Pharmacol</addtitle><date>1994</date><risdate>1994</risdate><volume>35</volume><issue>2</issue><spage>149</spage><epage>152</epage><pages>149-152</pages><issn>0344-5704</issn><eissn>1432-0843</eissn><coden>CCPHDZ</coden><abstract>To study tamoxifen resistance-stimulated growth, 30 female ovariectomized nude mice were implanted with tamoxifen-resistant tumors and treated with 10-1000 micrograms/day of tamoxifen citrate subcutaneously. Tamoxifen stimulated MCF-7 tumor growth in a dose-dependent manner, with tumoral tamoxifen concentrations increasing proportionally to the dose (1-13 nmol/g), as measured by high-performance liquid chromatography (HPLC). Flow-cytometric analysis revealed that tamoxifen-resistant tumors had a different DNA content as compared with wild-type MCF-7 cells. In contrast to earlier results, these data suggest that tamoxifen resistance-stimulated growth is associated with increasing rather than decreasing tumoral tamoxifen concentrations. Furthermore, the observed ploidy changes in the tamoxifen-resistant tumors imply that a genetic basis may exist for the development of tamoxifen resistance.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>7987992</pmid><doi>10.1007/BF00686638</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0344-5704 |
| ispartof | Cancer chemotherapy and pharmacology, 1994, Vol.35 (2), p.149-152 |
| issn | 0344-5704 1432-0843 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Antineoplastic agents Biological and medical sciences Cell Division - drug effects Chemotherapy Chromatography, High Pressure Liquid DNA, Neoplasm - drug effects Dose-Response Relationship, Drug Drug Resistance Female Medical sciences Mice Mice, Nude Neoplasm Transplantation Neoplasms, Experimental - drug therapy Neoplasms, Experimental - metabolism Ovariectomy Pharmacology. Drug treatments Tamoxifen - chemistry Tamoxifen - therapeutic use |
| title | Reduced tamoxifen accumulation is not associated with stimulated growth in tamoxifen resistance |
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