Undifferentiated Tumors: An Immunohistochemical Analysis on Biopsies

Immunohistochemical staining was performed on 145 biopsies with a diagnosis of undifferentiated or poorly differentiated tumor in order to classify them into lymphoid, epithelial, or mesenchymal in origin. It was possible to arrive at a histogenetic diagnosis on immunostaining in 85.5% of cases. Imm...

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Veröffentlicht in:Journal of surgical oncology 1994-12, Vol.57 (4), p.273-276
Hauptverfasser: Vege, Durga S., Soman, Chitralekha S., Joshi, Ujjwala A., Yadav, Jyoti N., Ganesh, Balasubramaniam
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container_end_page 276
container_issue 4
container_start_page 273
container_title Journal of surgical oncology
container_volume 57
creator Vege, Durga S.
Soman, Chitralekha S.
Joshi, Ujjwala A.
Yadav, Jyoti N.
Ganesh, Balasubramaniam
description Immunohistochemical staining was performed on 145 biopsies with a diagnosis of undifferentiated or poorly differentiated tumor in order to classify them into lymphoid, epithelial, or mesenchymal in origin. It was possible to arrive at a histogenetic diagnosis on immunostaining in 85.5% of cases. Immunostaining confirmed the diagnosis in 32.4% and contributed to diagnosis in 53.1%. Malignant lymphoma was the most common diagnosis (35.9%), followed by carcinoma (23.4%). A panel of antibodies consisting of anti‐common leucocyte antigen (LCA), anti‐epithelial membrane antigen (EMA), anti‐cytokeratin (CK), anti‐low to intermediate molecular weight cytokeratin (CAM 5.2), anti‐S‐100 protein (S‐100), and anti‐vimentin (VM) may resolve, to a large extent, some of the common diagnostic problems. © 1994 Wiley‐Liss, Inc.
doi_str_mv 10.1002/jso.2930570414
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects anti-common leucocyte antigen
anti-cytokeratin
anti-epithelial membrane antigen
anti-S-100 protein
anti-vimentin
Antibodies, Neoplasm - analysis
Biological and medical sciences
Biopsy
Carcinoma - diagnosis
Carcinoma - immunology
Diagnosis, Differential
Host-tumor relations. Immunology. Biological markers
Humans
Immunohistochemistry
Lymphoma - diagnosis
Lymphoma - immunology
Medical sciences
Tumors
title Undifferentiated Tumors: An Immunohistochemical Analysis on Biopsies
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