Temporal effects on antipyrine metabolite kinetics in aroclor 1254-treated rats
The in vivo consequences of a single dose of Aroclor 1254 (50 mg/kg) on the drug metabolizing capacity of rats were investigated. A noninvasive method, employing [ N-methyl- 14C]-antipyrine where both 14CO 2 exhalation and urinary excretion of 4-hydroxy-, 3-hydroxymethyl-, and norantipyrine were mon...
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| Veröffentlicht in: | Toxicology and applied pharmacology 1986-06, Vol.84 (2), p.232-240 |
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| container_title | Toxicology and applied pharmacology |
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| creator | Shaw, P.N. Houston, J.B. |
| description | The
in vivo consequences of a single dose of Aroclor 1254 (50 mg/kg) on the drug metabolizing capacity of rats were investigated. A noninvasive method, employing [
N-methyl-
14C]-antipyrine where both
14CO
2 exhalation and urinary excretion of 4-hydroxy-, 3-hydroxymethyl-, and norantipyrine were monitored, was used. A group of rats were sequentially tested over a 3-week period to characterize temporal patterns. The antipyrine metabolite kinetic approach demonstrated that induction of hepatic cytochrome
P-450 is maximal 3–6 days after Aroclor 1254 administration and the effects were apparent for at least a further 14–17 days. Evidence is presented to suggest selective effects of Aroclor 1254 on different cytochromes
P-450 are apparent
in vivo. |
| doi_str_mv | 10.1016/0041-008X(86)90130-4 |
| format | Article |
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in vivo consequences of a single dose of Aroclor 1254 (50 mg/kg) on the drug metabolizing capacity of rats were investigated. A noninvasive method, employing [
N-methyl-
14C]-antipyrine where both
14CO
2 exhalation and urinary excretion of 4-hydroxy-, 3-hydroxymethyl-, and norantipyrine were monitored, was used. A group of rats were sequentially tested over a 3-week period to characterize temporal patterns. The antipyrine metabolite kinetic approach demonstrated that induction of hepatic cytochrome
P-450 is maximal 3–6 days after Aroclor 1254 administration and the effects were apparent for at least a further 14–17 days. Evidence is presented to suggest selective effects of Aroclor 1254 on different cytochromes
P-450 are apparent
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in vivo consequences of a single dose of Aroclor 1254 (50 mg/kg) on the drug metabolizing capacity of rats were investigated. A noninvasive method, employing [
N-methyl-
14C]-antipyrine where both
14CO
2 exhalation and urinary excretion of 4-hydroxy-, 3-hydroxymethyl-, and norantipyrine were monitored, was used. A group of rats were sequentially tested over a 3-week period to characterize temporal patterns. The antipyrine metabolite kinetic approach demonstrated that induction of hepatic cytochrome
P-450 is maximal 3–6 days after Aroclor 1254 administration and the effects were apparent for at least a further 14–17 days. Evidence is presented to suggest selective effects of Aroclor 1254 on different cytochromes
P-450 are apparent
in vivo.</description><subject>Animals</subject><subject>Antipyrine - analogs & derivatives</subject><subject>Antipyrine - metabolism</subject><subject>Antipyrine - urine</subject><subject>Aroclors</subject><subject>Biological and medical sciences</subject><subject>Breath Tests</subject><subject>Carbon Dioxide - analysis</subject><subject>Carbon Radioisotopes</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chlorodiphenyl (54% Chlorine)</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cytochrome P-450 Enzyme System - biosynthesis</subject><subject>Edaravone</subject><subject>Enzyme Induction</subject><subject>Half-Life</subject><subject>Injections, Intraperitoneal</subject><subject>Kinetics</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0041-008X</issn><issn>1096-0333</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFKJDEQhsPi4o66b-BCH2RZD62VTjrpvgjLsOqC4EXBW0hXqiFud2c2yQi-vT3OMEc9FUV9f1F8xdgphwsOXF0CSF4CNE-_GnXeAhdQyi9swaFVJQghDthij3xjRyk9A0ArJT9khwIaDZVYsPsHGlch2qGgvifMqQhTYafsV6_RT1SMlG0XBp-p-Df32WMq_EzEgEOIBa9qWeZINpMros3phH3t7ZDo-64es8frPw_L2_Lu_ubv8vddiZLrXHYKXCOds4qkrLqq5zUp6VBodBZqjdT2ttLUUkMtV6IWErGfeZQVIO_EMfu53buK4f-aUjajT0jDYCcK62S0arQWVfUpyKXUda02oNyCGENKkXqzin608dVwMBvhZmPTbGyaRpl34UbOsR-7_etuJLcP7QzP87Pd3Ca0Qx_thD7tMd20nL9jV1uMZmkvnqJJ6GlCcj7ObzEu-I_veAMfPJyN</recordid><startdate>19860630</startdate><enddate>19860630</enddate><creator>Shaw, P.N.</creator><creator>Houston, J.B.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19860630</creationdate><title>Temporal effects on antipyrine metabolite kinetics in aroclor 1254-treated rats</title><author>Shaw, P.N. ; Houston, J.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-b60d84dda6e442b2f15e64dc37cda057ce9fa27e9e8e9163534ccfddac420c1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Antipyrine - analogs & derivatives</topic><topic>Antipyrine - metabolism</topic><topic>Antipyrine - urine</topic><topic>Aroclors</topic><topic>Biological and medical sciences</topic><topic>Breath Tests</topic><topic>Carbon Dioxide - analysis</topic><topic>Carbon Radioisotopes</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chlorodiphenyl (54% Chlorine)</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cytochrome P-450 Enzyme System - biosynthesis</topic><topic>Edaravone</topic><topic>Enzyme Induction</topic><topic>Half-Life</topic><topic>Injections, Intraperitoneal</topic><topic>Kinetics</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shaw, P.N.</creatorcontrib><creatorcontrib>Houston, J.B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology and applied pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shaw, P.N.</au><au>Houston, J.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Temporal effects on antipyrine metabolite kinetics in aroclor 1254-treated rats</atitle><jtitle>Toxicology and applied pharmacology</jtitle><addtitle>Toxicol Appl Pharmacol</addtitle><date>1986-06-30</date><risdate>1986</risdate><volume>84</volume><issue>2</issue><spage>232</spage><epage>240</epage><pages>232-240</pages><issn>0041-008X</issn><eissn>1096-0333</eissn><coden>TXAPA9</coden><abstract>The
in vivo consequences of a single dose of Aroclor 1254 (50 mg/kg) on the drug metabolizing capacity of rats were investigated. A noninvasive method, employing [
N-methyl-
14C]-antipyrine where both
14CO
2 exhalation and urinary excretion of 4-hydroxy-, 3-hydroxymethyl-, and norantipyrine were monitored, was used. A group of rats were sequentially tested over a 3-week period to characterize temporal patterns. The antipyrine metabolite kinetic approach demonstrated that induction of hepatic cytochrome
P-450 is maximal 3–6 days after Aroclor 1254 administration and the effects were apparent for at least a further 14–17 days. Evidence is presented to suggest selective effects of Aroclor 1254 on different cytochromes
P-450 are apparent
in vivo.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>3087023</pmid><doi>10.1016/0041-008X(86)90130-4</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-008X |
| ispartof | Toxicology and applied pharmacology, 1986-06, Vol.84 (2), p.232-240 |
| issn | 0041-008X 1096-0333 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76877322 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antipyrine - analogs & derivatives Antipyrine - metabolism Antipyrine - urine Aroclors Biological and medical sciences Breath Tests Carbon Dioxide - analysis Carbon Radioisotopes Chemical and industrial products toxicology. Toxic occupational diseases Chlorodiphenyl (54% Chlorine) Chromatography, High Pressure Liquid Cytochrome P-450 Enzyme System - biosynthesis Edaravone Enzyme Induction Half-Life Injections, Intraperitoneal Kinetics Liver - drug effects Liver - metabolism Male Medical sciences Rats Rats, Inbred Strains Toxicology Various organic compounds |
| title | Temporal effects on antipyrine metabolite kinetics in aroclor 1254-treated rats |
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