Orally administered immunosuppressants modify intestinal uptake of nutrients in rabbits

The effect on intestinal nutrient transport of the immunosuppressive drugs cyclosporin A (CsA), cyclosporin G (CsG), and rapamycin (RAP) was determined in New Zealand white rabbits. Rabbits received oral doses of CsA (20 mg/kg/day), CsG (10 mg/kg/day), or RAP (1 mg/kg/day) for 10 days. Animals recei...

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Veröffentlicht in:	Transplantation 1994-12, Vol.58 (11), p.1241-1246
Hauptverfasser:	DIAS, V. C, MADSEN, K. L, YATSCOFF, R. W, DORING, K, THOMSON, A. B. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Cholesterol - pharmacokinetics Cyclosporine - pharmacology Cyclosporins - pharmacology Fatty Acids - pharmacokinetics Glucose - pharmacokinetics Ileum - drug effects Ileum - metabolism Immunomodulators Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacology Intestinal Mucosa - anatomy & histology Jejunum - drug effects Jejunum - metabolism Male Medical sciences Pharmacology. Drug treatments Polyenes - pharmacology Rabbits Sirolimus Weight Gain - drug effects
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