Systemic and mucosal immunity induced by BCG vector expressing outer-surface protein A of Borrelia burgdorferi

THE bacillus Calmette–Guerin (BCG) is a live attenuated strain of Mycobacterium bovis which offers potential advantages as a vector for mucosal delivery of antigens 1–3 . Recombinant BCG elicits protective humoral immune responses to a variety of antigens 4 . Furthermore, BCG binds specifically to m...

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Veröffentlicht in:	Nature (London) 1994-12, Vol.372 (6506), p.552-555
Hauptverfasser:	Langermann, Solomon, Palaszynski, Susan, Sadziene, Ariadna, Stover, C. Kendall, Koenig, Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Antibodies, Bacterial - immunology Antigens, Surface - genetics Antigens, Surface - immunology B-Lymphocytes - immunology Bacteria Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacterial Vaccines - genetics Bacterial Vaccines - immunology Bacteriology BCG Vaccine - genetics BCG Vaccine - immunology Biological and medical sciences Borrelia burgdorferi Borrelia burgdorferi Group - genetics Borrelia burgdorferi Group - immunology Cellular biology Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Immune system Immunity (Disease) Immunization Immunoglobulin A, Secretory - immunology Immunoglobulin G - immunology letter Lipoproteins Lung - immunology Lyme Disease - immunology Lyme Disease - prevention & control Lymphocytes Mice Mice, Inbred BALB C Microbiology Mucous membrane multidisciplinary Mycobacterium bovis Nasopharynx - immunology Proteins Science Science (multidisciplinary) Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology
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