Atrial natriuretic factor in cirrhosis: relationship to renal function and hemodynamic changes
Plasma atrial natriuretic factor concentrations and different hemodynamic parameters, including the evaluation of femoral arteriovenous shunting by measuring the arteriovenous difference of oxygen content (Ca-vO 2), were determined in eight healthy subjects and 24 patients with cirrhosis without ren...
Gespeichert in:
| Veröffentlicht in: | Journal of hepatology 1994-08, Vol.21 (2), p.211-216 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 216 |
|---|---|
| container_issue | 2 |
| container_start_page | 211 |
| container_title | Journal of hepatology |
| container_volume | 21 |
| creator | Fernández-Rodriguez, Conrado Prieto, Jesús Quiroga, Jorge Zozaya, Jose M. Andrade, Amalia Rodriguez-Martinez, Dolores |
| description | Plasma atrial natriuretic factor concentrations and different hemodynamic parameters, including the evaluation of femoral arteriovenous shunting by measuring the arteriovenous difference of oxygen content (Ca-vO
2), were determined in eight healthy subjects and 24 patients with cirrhosis without renal failure (group I: seven patients without ascites, group II: nine patients with ascites and UNaV>10 mEq/24 h and group III: eight patients with ascites and UNaV≤10 mEq/24 h). Atrial natriuretic factor was 34±4.7 pg/ml in the control group and 44.28±5.4, 67.89±8.8 and 84±10.8 pg/ml in groups I, II and III respectively (
p |
| doi_str_mv | 10.1016/S0168-8278(05)80397-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76875343</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168827805803976</els_id><sourcerecordid>76875343</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-fe7aaa2f2b15652020dba527850a3f02c97cad773ba3a1908a92e014435940bd3</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhi1EVZbCT6iUA0JwSDu24zjmUlUVX1KlHoAr1sSZsEaJvdgJUv893u5qr1w8sueZ8auHsUsOVxx4e_2tHF3dCd29A_W-A2l03T5jG94C1NA2_DnbnJAX7GXOvwFAgmnO2bk2ndGcb9jP2yV5nKqApa6JFu-qEd0SU-VD5XxK25h9_lAlmnDxMeSt31VLLPdQxsY1uP1rhWGotjTH4THgXHa4LYZflF-xsxGnTK-P9YL9-PTx-92X-v7h89e72_vayc4s9UgaEcUoeq5aJUDA0KMquRWgHEE4ox0OWsseJXIDHRpBwJtGKtNAP8gL9vawd5fin5XyYmefHU0TBoprtrrttJKNLKA6gC7FnBONdpf8jOnRcrB7r_bJq91Ls6Dsk1fblrnL4wdrP9NwmjqKLP03xz5mh9OYMDifT1gjREmtC3ZzwKjI-Osp2ew8BUeDT-QWO0T_nyD_AFF-lWk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76875343</pqid></control><display><type>article</type><title>Atrial natriuretic factor in cirrhosis: relationship to renal function and hemodynamic changes</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Fernández-Rodriguez, Conrado ; Prieto, Jesús ; Quiroga, Jorge ; Zozaya, Jose M. ; Andrade, Amalia ; Rodriguez-Martinez, Dolores</creator><creatorcontrib>Fernández-Rodriguez, Conrado ; Prieto, Jesús ; Quiroga, Jorge ; Zozaya, Jose M. ; Andrade, Amalia ; Rodriguez-Martinez, Dolores</creatorcontrib><description><![CDATA[Plasma atrial natriuretic factor concentrations and different hemodynamic parameters, including the evaluation of femoral arteriovenous shunting by measuring the arteriovenous difference of oxygen content (Ca-vO
2), were determined in eight healthy subjects and 24 patients with cirrhosis without renal failure (group I: seven patients without ascites, group II: nine patients with ascites and UNaV>10 mEq/24 h and group III: eight patients with ascites and UNaV≤10 mEq/24 h). Atrial natriuretic factor was 34±4.7 pg/ml in the control group and 44.28±5.4, 67.89±8.8 and 84±10.8 pg/ml in groups I, II and III respectively (
p<0.001. group III vs. I and control and II vs. control). Atrial natriuretic factor directly correlated with cardiac index (
p<0.01), blood volume (
p: 0.01), femoral blood flow (
p<0.01) and inversely with systemic and femoral vascular resistances (
p<0.02), Ca-vO
2 (
p<0.01), serum albumin (r: −0.61;
p<0.01) and prothrombin index (r: −0.63;
p<0.02). These results indicate that plasma atrial natriuretic factor is increased in patients with cirrhosis, especially in those with advanced disease and marked renal sodium retention. This suggests that in cirrhosis, arteriolar vasodilation and peripheral arteriovenous shunting influence renal function while inducing a state of overflow at the central venous compartment leading to increased atrial natriuretic factor secretion. Increased production of this vasodilatory hormone may thus contribute to the hyperkinetic circulation of cirrhosis.]]></description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/S0168-8278(05)80397-6</identifier><identifier>PMID: 7989711</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Arteriovenous shunts ; Atrial Natriuretic Factor - blood ; Atrial Natriuretic Factor - physiology ; Biological and medical sciences ; Blood Gas Analysis ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Hemodynamics - physiology ; Humans ; Kidney - blood supply ; Kidney - physiology ; Liver - blood supply ; Liver Cirrhosis - blood ; Liver Cirrhosis - physiopathology ; Liver function ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Natriuresis ; Other diseases. Semiology ; Vascular Resistance - physiology</subject><ispartof>Journal of hepatology, 1994-08, Vol.21 (2), p.211-216</ispartof><rights>1994 Journal of Hepatology</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-fe7aaa2f2b15652020dba527850a3f02c97cad773ba3a1908a92e014435940bd3</citedby><cites>FETCH-LOGICAL-c389t-fe7aaa2f2b15652020dba527850a3f02c97cad773ba3a1908a92e014435940bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0168-8278(05)80397-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4229087$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7989711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández-Rodriguez, Conrado</creatorcontrib><creatorcontrib>Prieto, Jesús</creatorcontrib><creatorcontrib>Quiroga, Jorge</creatorcontrib><creatorcontrib>Zozaya, Jose M.</creatorcontrib><creatorcontrib>Andrade, Amalia</creatorcontrib><creatorcontrib>Rodriguez-Martinez, Dolores</creatorcontrib><title>Atrial natriuretic factor in cirrhosis: relationship to renal function and hemodynamic changes</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description><![CDATA[Plasma atrial natriuretic factor concentrations and different hemodynamic parameters, including the evaluation of femoral arteriovenous shunting by measuring the arteriovenous difference of oxygen content (Ca-vO
2), were determined in eight healthy subjects and 24 patients with cirrhosis without renal failure (group I: seven patients without ascites, group II: nine patients with ascites and UNaV>10 mEq/24 h and group III: eight patients with ascites and UNaV≤10 mEq/24 h). Atrial natriuretic factor was 34±4.7 pg/ml in the control group and 44.28±5.4, 67.89±8.8 and 84±10.8 pg/ml in groups I, II and III respectively (
p<0.001. group III vs. I and control and II vs. control). Atrial natriuretic factor directly correlated with cardiac index (
p<0.01), blood volume (
p: 0.01), femoral blood flow (
p<0.01) and inversely with systemic and femoral vascular resistances (
p<0.02), Ca-vO
2 (
p<0.01), serum albumin (r: −0.61;
p<0.01) and prothrombin index (r: −0.63;
p<0.02). These results indicate that plasma atrial natriuretic factor is increased in patients with cirrhosis, especially in those with advanced disease and marked renal sodium retention. This suggests that in cirrhosis, arteriolar vasodilation and peripheral arteriovenous shunting influence renal function while inducing a state of overflow at the central venous compartment leading to increased atrial natriuretic factor secretion. Increased production of this vasodilatory hormone may thus contribute to the hyperkinetic circulation of cirrhosis.]]></description><subject>Arteriovenous shunts</subject><subject>Atrial Natriuretic Factor - blood</subject><subject>Atrial Natriuretic Factor - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood Gas Analysis</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Kidney - blood supply</subject><subject>Kidney - physiology</subject><subject>Liver - blood supply</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Liver function</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Natriuresis</subject><subject>Other diseases. Semiology</subject><subject>Vascular Resistance - physiology</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1EVZbCT6iUA0JwSDu24zjmUlUVX1KlHoAr1sSZsEaJvdgJUv893u5qr1w8sueZ8auHsUsOVxx4e_2tHF3dCd29A_W-A2l03T5jG94C1NA2_DnbnJAX7GXOvwFAgmnO2bk2ndGcb9jP2yV5nKqApa6JFu-qEd0SU-VD5XxK25h9_lAlmnDxMeSt31VLLPdQxsY1uP1rhWGotjTH4THgXHa4LYZflF-xsxGnTK-P9YL9-PTx-92X-v7h89e72_vayc4s9UgaEcUoeq5aJUDA0KMquRWgHEE4ox0OWsseJXIDHRpBwJtGKtNAP8gL9vawd5fin5XyYmefHU0TBoprtrrttJKNLKA6gC7FnBONdpf8jOnRcrB7r_bJq91Ls6Dsk1fblrnL4wdrP9NwmjqKLP03xz5mh9OYMDifT1gjREmtC3ZzwKjI-Osp2ew8BUeDT-QWO0T_nyD_AFF-lWk</recordid><startdate>19940801</startdate><enddate>19940801</enddate><creator>Fernández-Rodriguez, Conrado</creator><creator>Prieto, Jesús</creator><creator>Quiroga, Jorge</creator><creator>Zozaya, Jose M.</creator><creator>Andrade, Amalia</creator><creator>Rodriguez-Martinez, Dolores</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940801</creationdate><title>Atrial natriuretic factor in cirrhosis: relationship to renal function and hemodynamic changes</title><author>Fernández-Rodriguez, Conrado ; Prieto, Jesús ; Quiroga, Jorge ; Zozaya, Jose M. ; Andrade, Amalia ; Rodriguez-Martinez, Dolores</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-fe7aaa2f2b15652020dba527850a3f02c97cad773ba3a1908a92e014435940bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Arteriovenous shunts</topic><topic>Atrial Natriuretic Factor - blood</topic><topic>Atrial Natriuretic Factor - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood Gas Analysis</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Kidney - blood supply</topic><topic>Kidney - physiology</topic><topic>Liver - blood supply</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Liver function</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Natriuresis</topic><topic>Other diseases. Semiology</topic><topic>Vascular Resistance - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández-Rodriguez, Conrado</creatorcontrib><creatorcontrib>Prieto, Jesús</creatorcontrib><creatorcontrib>Quiroga, Jorge</creatorcontrib><creatorcontrib>Zozaya, Jose M.</creatorcontrib><creatorcontrib>Andrade, Amalia</creatorcontrib><creatorcontrib>Rodriguez-Martinez, Dolores</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-Rodriguez, Conrado</au><au>Prieto, Jesús</au><au>Quiroga, Jorge</au><au>Zozaya, Jose M.</au><au>Andrade, Amalia</au><au>Rodriguez-Martinez, Dolores</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atrial natriuretic factor in cirrhosis: relationship to renal function and hemodynamic changes</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>1994-08-01</date><risdate>1994</risdate><volume>21</volume><issue>2</issue><spage>211</spage><epage>216</epage><pages>211-216</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract><![CDATA[Plasma atrial natriuretic factor concentrations and different hemodynamic parameters, including the evaluation of femoral arteriovenous shunting by measuring the arteriovenous difference of oxygen content (Ca-vO
2), were determined in eight healthy subjects and 24 patients with cirrhosis without renal failure (group I: seven patients without ascites, group II: nine patients with ascites and UNaV>10 mEq/24 h and group III: eight patients with ascites and UNaV≤10 mEq/24 h). Atrial natriuretic factor was 34±4.7 pg/ml in the control group and 44.28±5.4, 67.89±8.8 and 84±10.8 pg/ml in groups I, II and III respectively (
p<0.001. group III vs. I and control and II vs. control). Atrial natriuretic factor directly correlated with cardiac index (
p<0.01), blood volume (
p: 0.01), femoral blood flow (
p<0.01) and inversely with systemic and femoral vascular resistances (
p<0.02), Ca-vO
2 (
p<0.01), serum albumin (r: −0.61;
p<0.01) and prothrombin index (r: −0.63;
p<0.02). These results indicate that plasma atrial natriuretic factor is increased in patients with cirrhosis, especially in those with advanced disease and marked renal sodium retention. This suggests that in cirrhosis, arteriolar vasodilation and peripheral arteriovenous shunting influence renal function while inducing a state of overflow at the central venous compartment leading to increased atrial natriuretic factor secretion. Increased production of this vasodilatory hormone may thus contribute to the hyperkinetic circulation of cirrhosis.]]></abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>7989711</pmid><doi>10.1016/S0168-8278(05)80397-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8278 |
| ispartof | Journal of hepatology, 1994-08, Vol.21 (2), p.211-216 |
| issn | 0168-8278 1600-0641 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76875343 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Arteriovenous shunts Atrial Natriuretic Factor - blood Atrial Natriuretic Factor - physiology Biological and medical sciences Blood Gas Analysis Female Gastroenterology. Liver. Pancreas. Abdomen Hemodynamics - physiology Humans Kidney - blood supply Kidney - physiology Liver - blood supply Liver Cirrhosis - blood Liver Cirrhosis - physiopathology Liver function Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Natriuresis Other diseases. Semiology Vascular Resistance - physiology |
| title | Atrial natriuretic factor in cirrhosis: relationship to renal function and hemodynamic changes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T16%3A49%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Atrial%20natriuretic%20factor%20in%20cirrhosis:%20relationship%20to%20renal%20function%20and%20hemodynamic%20changes&rft.jtitle=Journal%20of%20hepatology&rft.au=Fern%C3%A1ndez-Rodriguez,%20Conrado&rft.date=1994-08-01&rft.volume=21&rft.issue=2&rft.spage=211&rft.epage=216&rft.pages=211-216&rft.issn=0168-8278&rft.eissn=1600-0641&rft.coden=JOHEEC&rft_id=info:doi/10.1016/S0168-8278(05)80397-6&rft_dat=%3Cproquest_cross%3E76875343%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76875343&rft_id=info:pmid/7989711&rft_els_id=S0168827805803976&rfr_iscdi=true |