Formation and inactivation of endogenous cannabinoid anandamide in central neurons

ANANDAMIDE ( N -arachidonoyl-ethanolamine) was recently identified as a brain arachidonate derivative that binds to and activates cannabinoid receptors 1–4 , yet the mechanisms underlying formation, release and inactivation of this putative messenger molecule are still unclear. Here we report that a...

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Veröffentlicht in:	Nature (London) 1994-12, Vol.372 (6507), p.686-691
Hauptverfasser:	Di Marzo, Vincenzo, Fontana, Angelo, Cadas, Hugues, Schinelli, Sergio, Cimino, Guido, Schwartz, Jean-Charles, Piomelli, Danlele
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - metabolism Astrocytes - metabolism Biochemistry Biochemistry and metabolism Biological and medical sciences Brain Calcium Cannabinoids - metabolism Cells, Cultured Central nervous system Central Nervous System - drug effects Central Nervous System - metabolism Cerebral Cortex - metabolism Corpus Striatum - metabolism Endocannabinoids Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Inactivation Ionomycin - pharmacology letter Marijuana multidisciplinary Neurology Neurons - drug effects Neurons - metabolism Phosphatidylethanolamines - metabolism Polyunsaturated Alkamides Rats Science Science (multidisciplinary) Signal Transduction Vertebrates: nervous system and sense organs
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