Galanin: Evidence for a hypothalamic site of action to release growth hormone
Galanin is a 29 amino acid peptide that was isolated and characterized from porcine intestinal extracts. The presence of galanin-like immunoreactivity in neuronal elements in the hypothalamus and median eminence suggested a role for it in the hypothalamic control of anterior pituitary function. A hy...
Gespeichert in:
| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1986, Vol.7 (1), p.51-53 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 53 |
|---|---|
| container_issue | 1 |
| container_start_page | 51 |
| container_title | Peptides (New York, N.Y. : 1980) |
| container_volume | 7 |
| creator | Ottlecz, Anna Samson, Willis K. McCann, S.M. |
| description | Galanin is a 29 amino acid peptide that was isolated and characterized from porcine intestinal extracts. The presence of galanin-like immunoreactivity in neuronal elements in the hypothalamus and median eminence suggested a role for it in the hypothalamic control of anterior pituitary function. A hypothalamic site of action of galanin to stimulate growth hormone (GH) release is suggested by our observations that doses as low as 50 picomoles when infused into the third cerebroventricle of conscious, unrestrained ovariectomized rats resulted in significantly elevated plasma levels of GH. This effect was specific for GH and was dose-related. The failure of galanin to alter GH release from dispersed, cultured anterior pituitary cells
in vitro further suggests that endogenous galanin plays a neuromodulatory role at the level of the median eminence, possibly affecting the release of known GH-releasing and/or inhibiting factors. |
| doi_str_mv | 10.1016/0196-9781(86)90060-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76869373</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0196978186900604</els_id><sourcerecordid>14652874</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-e5e61883a889fed0f1ffcc9ce5bae00ab3dc85771bb4d0b3378160406344d9c23</originalsourceid><addsrcrecordid>eNqFkcFO3DAQhq0KBFvoG4DkA6raQ2AcO47NAalCFJBAXNqz5Thj1iiJFzsL4u2baFd7LKc5_N-MZr4h5ITBOQMmL4BpWehasR9K_tQAEgrxhSyYqnlRMan3yGKHHJKvOb8AgBBaHZCDUpRca7Ygj7e2s0MYLunNW2hxcEh9TNTS5ccqjssp7IOjOYxIo6fWjSEOdIw0YYc2I31O8X1c0mVMfRzwmOx722X8tq1H5O_vmz_Xd8XD0-399a-HwglWjwVWKJlS3CqlPbbgmffOaYdVYxHANrx1qqpr1jSihYbz6QIJAiQXotWu5Efk-2buKsXXNebR9CE77KZTMK6zqaWSmtf8U5AJWZWqFhMoNqBLMeeE3qxS6G36MAzMrNvMLs3s0qipzrrN3Ha6nb9uemx3TVu_U362zW12tvPJDi7kHaaAq7KSE3a1wXCS9hYwmezC_Iw2JHSjaWP4_x7_AMG1mw0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14652874</pqid></control><display><type>article</type><title>Galanin: Evidence for a hypothalamic site of action to release growth hormone</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Ottlecz, Anna ; Samson, Willis K. ; McCann, S.M.</creator><creatorcontrib>Ottlecz, Anna ; Samson, Willis K. ; McCann, S.M.</creatorcontrib><description>Galanin is a 29 amino acid peptide that was isolated and characterized from porcine intestinal extracts. The presence of galanin-like immunoreactivity in neuronal elements in the hypothalamus and median eminence suggested a role for it in the hypothalamic control of anterior pituitary function. A hypothalamic site of action of galanin to stimulate growth hormone (GH) release is suggested by our observations that doses as low as 50 picomoles when infused into the third cerebroventricle of conscious, unrestrained ovariectomized rats resulted in significantly elevated plasma levels of GH. This effect was specific for GH and was dose-related. The failure of galanin to alter GH release from dispersed, cultured anterior pituitary cells
in vitro further suggests that endogenous galanin plays a neuromodulatory role at the level of the median eminence, possibly affecting the release of known GH-releasing and/or inhibiting factors.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(86)90060-4</identifier><identifier>PMID: 2423991</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Anterior pituitary function ; Biological and medical sciences ; Cerebral Ventricles - drug effects ; Cerebral Ventricles - physiology ; Dose-Response Relationship, Drug ; Female ; Fundamental and applied biological sciences. Psychology ; Galanin ; Growth hormone ; Growth Hormone - blood ; Growth Hormone - metabolism ; Hormones and neuropeptides. Regulation ; Hypothalamo-Hypophyseal System - physiology ; Hypothalamus ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Injections, Intraventricular ; Median eminence ; Ovariectomy ; Peptides - administration & dosage ; Peptides - pharmacology ; Pituitary Gland, Anterior - drug effects ; Pituitary Gland, Anterior - metabolism ; Prolactin - blood ; Rats ; Rats, Inbred Strains ; Vertebrates: endocrinology</subject><ispartof>Peptides (New York, N.Y. : 1980), 1986, Vol.7 (1), p.51-53</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e5e61883a889fed0f1ffcc9ce5bae00ab3dc85771bb4d0b3378160406344d9c23</citedby><cites>FETCH-LOGICAL-c417t-e5e61883a889fed0f1ffcc9ce5bae00ab3dc85771bb4d0b3378160406344d9c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(86)90060-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8038256$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2423991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ottlecz, Anna</creatorcontrib><creatorcontrib>Samson, Willis K.</creatorcontrib><creatorcontrib>McCann, S.M.</creatorcontrib><title>Galanin: Evidence for a hypothalamic site of action to release growth hormone</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Galanin is a 29 amino acid peptide that was isolated and characterized from porcine intestinal extracts. The presence of galanin-like immunoreactivity in neuronal elements in the hypothalamus and median eminence suggested a role for it in the hypothalamic control of anterior pituitary function. A hypothalamic site of action of galanin to stimulate growth hormone (GH) release is suggested by our observations that doses as low as 50 picomoles when infused into the third cerebroventricle of conscious, unrestrained ovariectomized rats resulted in significantly elevated plasma levels of GH. This effect was specific for GH and was dose-related. The failure of galanin to alter GH release from dispersed, cultured anterior pituitary cells
in vitro further suggests that endogenous galanin plays a neuromodulatory role at the level of the median eminence, possibly affecting the release of known GH-releasing and/or inhibiting factors.</description><subject>Animals</subject><subject>Anterior pituitary function</subject><subject>Biological and medical sciences</subject><subject>Cerebral Ventricles - drug effects</subject><subject>Cerebral Ventricles - physiology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Galanin</subject><subject>Growth hormone</subject><subject>Growth Hormone - blood</subject><subject>Growth Hormone - metabolism</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamo-Hypophyseal System - physiology</subject><subject>Hypothalamus</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Injections, Intraventricular</subject><subject>Median eminence</subject><subject>Ovariectomy</subject><subject>Peptides - administration & dosage</subject><subject>Peptides - pharmacology</subject><subject>Pituitary Gland, Anterior - drug effects</subject><subject>Pituitary Gland, Anterior - metabolism</subject><subject>Prolactin - blood</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: endocrinology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFO3DAQhq0KBFvoG4DkA6raQ2AcO47NAalCFJBAXNqz5Thj1iiJFzsL4u2baFd7LKc5_N-MZr4h5ITBOQMmL4BpWehasR9K_tQAEgrxhSyYqnlRMan3yGKHHJKvOb8AgBBaHZCDUpRca7Ygj7e2s0MYLunNW2hxcEh9TNTS5ccqjssp7IOjOYxIo6fWjSEOdIw0YYc2I31O8X1c0mVMfRzwmOx722X8tq1H5O_vmz_Xd8XD0-399a-HwglWjwVWKJlS3CqlPbbgmffOaYdVYxHANrx1qqpr1jSihYbz6QIJAiQXotWu5Efk-2buKsXXNebR9CE77KZTMK6zqaWSmtf8U5AJWZWqFhMoNqBLMeeE3qxS6G36MAzMrNvMLs3s0qipzrrN3Ha6nb9uemx3TVu_U362zW12tvPJDi7kHaaAq7KSE3a1wXCS9hYwmezC_Iw2JHSjaWP4_x7_AMG1mw0</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Ottlecz, Anna</creator><creator>Samson, Willis K.</creator><creator>McCann, S.M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Galanin: Evidence for a hypothalamic site of action to release growth hormone</title><author>Ottlecz, Anna ; Samson, Willis K. ; McCann, S.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-e5e61883a889fed0f1ffcc9ce5bae00ab3dc85771bb4d0b3378160406344d9c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Anterior pituitary function</topic><topic>Biological and medical sciences</topic><topic>Cerebral Ventricles - drug effects</topic><topic>Cerebral Ventricles - physiology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Galanin</topic><topic>Growth hormone</topic><topic>Growth Hormone - blood</topic><topic>Growth Hormone - metabolism</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamo-Hypophyseal System - physiology</topic><topic>Hypothalamus</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Injections, Intraventricular</topic><topic>Median eminence</topic><topic>Ovariectomy</topic><topic>Peptides - administration & dosage</topic><topic>Peptides - pharmacology</topic><topic>Pituitary Gland, Anterior - drug effects</topic><topic>Pituitary Gland, Anterior - metabolism</topic><topic>Prolactin - blood</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ottlecz, Anna</creatorcontrib><creatorcontrib>Samson, Willis K.</creatorcontrib><creatorcontrib>McCann, S.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ottlecz, Anna</au><au>Samson, Willis K.</au><au>McCann, S.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Galanin: Evidence for a hypothalamic site of action to release growth hormone</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1986</date><risdate>1986</risdate><volume>7</volume><issue>1</issue><spage>51</spage><epage>53</epage><pages>51-53</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Galanin is a 29 amino acid peptide that was isolated and characterized from porcine intestinal extracts. The presence of galanin-like immunoreactivity in neuronal elements in the hypothalamus and median eminence suggested a role for it in the hypothalamic control of anterior pituitary function. A hypothalamic site of action of galanin to stimulate growth hormone (GH) release is suggested by our observations that doses as low as 50 picomoles when infused into the third cerebroventricle of conscious, unrestrained ovariectomized rats resulted in significantly elevated plasma levels of GH. This effect was specific for GH and was dose-related. The failure of galanin to alter GH release from dispersed, cultured anterior pituitary cells
in vitro further suggests that endogenous galanin plays a neuromodulatory role at the level of the median eminence, possibly affecting the release of known GH-releasing and/or inhibiting factors.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2423991</pmid><doi>10.1016/0196-9781(86)90060-4</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 1986, Vol.7 (1), p.51-53 |
| issn | 0196-9781 1873-5169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76869373 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Anterior pituitary function Biological and medical sciences Cerebral Ventricles - drug effects Cerebral Ventricles - physiology Dose-Response Relationship, Drug Female Fundamental and applied biological sciences. Psychology Galanin Growth hormone Growth Hormone - blood Growth Hormone - metabolism Hormones and neuropeptides. Regulation Hypothalamo-Hypophyseal System - physiology Hypothalamus Hypothalamus. Hypophysis. Epiphysis. Urophysis Injections, Intraventricular Median eminence Ovariectomy Peptides - administration & dosage Peptides - pharmacology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Prolactin - blood Rats Rats, Inbred Strains Vertebrates: endocrinology |
| title | Galanin: Evidence for a hypothalamic site of action to release growth hormone |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T16%3A50%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Galanin:%20Evidence%20for%20a%20hypothalamic%20site%20of%20action%20to%20release%20growth%20hormone&rft.jtitle=Peptides%20(New%20York,%20N.Y.%20:%201980)&rft.au=Ottlecz,%20Anna&rft.date=1986&rft.volume=7&rft.issue=1&rft.spage=51&rft.epage=53&rft.pages=51-53&rft.issn=0196-9781&rft.eissn=1873-5169&rft.coden=PPTDD5&rft_id=info:doi/10.1016/0196-9781(86)90060-4&rft_dat=%3Cproquest_cross%3E14652874%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14652874&rft_id=info:pmid/2423991&rft_els_id=0196978186900604&rfr_iscdi=true |