Tumor suppressor and immediate early transcription factor genes in non-small cell lung cancer
Non-small lung cancer (NSCLC) is a disease that exhibits multiple genetic lesions. Lung Cancer Study Group (LCSG) 871 was designed to analyze this group of malignancies for alterations in growth factors and/or their receptors, oncogenes, tumor suppressor genes, and immediate early transcription fact...
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| Veröffentlicht in: | Chest 1994-12, Vol.106 (6 Suppl), p.372S-376 |
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| container_issue | 6 Suppl |
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| container_title | Chest |
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| creator | Levin, W J Casey, G Ramos, J C Arboleda, M J Reissmann, P T Slamon, D J |
| description | Non-small lung cancer (NSCLC) is a disease that exhibits multiple genetic lesions. Lung Cancer Study Group (LCSG) 871 was designed to analyze this group of malignancies for alterations in growth factors and/or their receptors, oncogenes, tumor suppressor genes, and immediate early transcription factor genes. Immunohistochemical analysis showed that 32% of evaluable cases studied contained absent or abnormal Rb expression. Sequence analysis of the p53 gene revealed that 58% of these cancers contained structural alterations of this gene, whereas only 45% of these cases overexpressed p53 by immunohistochemical analysis. Finally, both Northern blot and immunohistochemical analysis showed that these tumors exhibited changes in the mRNA and protein expression levels respectively of the immediate early transcription factor genes c-fos, c-jun, and EGR, in that less expression of these genes was evident in the tumors compared with adjacent normal tissue. Understanding both the biologic and molecular significance of these findings may allow us to explore novel modalities for treatment of this disease. |
| doi_str_mv | 10.1378/chest.106.6.372s |
| format | Article |
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Lung Cancer Study Group (LCSG) 871 was designed to analyze this group of malignancies for alterations in growth factors and/or their receptors, oncogenes, tumor suppressor genes, and immediate early transcription factor genes. Immunohistochemical analysis showed that 32% of evaluable cases studied contained absent or abnormal Rb expression. Sequence analysis of the p53 gene revealed that 58% of these cancers contained structural alterations of this gene, whereas only 45% of these cases overexpressed p53 by immunohistochemical analysis. Finally, both Northern blot and immunohistochemical analysis showed that these tumors exhibited changes in the mRNA and protein expression levels respectively of the immediate early transcription factor genes c-fos, c-jun, and EGR, in that less expression of these genes was evident in the tumors compared with adjacent normal tissue. Understanding both the biologic and molecular significance of these findings may allow us to explore novel modalities for treatment of this disease.</description><identifier>ISSN: 0012-3692</identifier><identifier>DOI: 10.1378/chest.106.6.372s</identifier><identifier>PMID: 7988267</identifier><language>eng</language><publisher>United States</publisher><subject>Carcinoma, Non-Small-Cell Lung - genetics ; Clinical Trials as Topic ; Gene Expression ; Genes, fos - genetics ; Genes, jun - genetics ; Genes, p53 - genetics ; Genes, Tumor Suppressor ; Humans ; Immunohistochemistry ; Lung Neoplasms - genetics ; Multicenter Studies as Topic ; Mutation ; Randomized Controlled Trials as Topic ; RNA Probes ; Sequence Analysis, DNA ; Transcription, Genetic</subject><ispartof>Chest, 1994-12, Vol.106 (6 Suppl), p.372S-376</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c209t-6d9eae5b0e0d0fa0b65c4c01a34f7e71788b7aa536cad3f90ed40e228bc488bb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7988267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levin, W J</creatorcontrib><creatorcontrib>Casey, G</creatorcontrib><creatorcontrib>Ramos, J C</creatorcontrib><creatorcontrib>Arboleda, M J</creatorcontrib><creatorcontrib>Reissmann, P T</creatorcontrib><creatorcontrib>Slamon, D J</creatorcontrib><title>Tumor suppressor and immediate early transcription factor genes in non-small cell lung cancer</title><title>Chest</title><addtitle>Chest</addtitle><description>Non-small lung cancer (NSCLC) is a disease that exhibits multiple genetic lesions. Lung Cancer Study Group (LCSG) 871 was designed to analyze this group of malignancies for alterations in growth factors and/or their receptors, oncogenes, tumor suppressor genes, and immediate early transcription factor genes. Immunohistochemical analysis showed that 32% of evaluable cases studied contained absent or abnormal Rb expression. Sequence analysis of the p53 gene revealed that 58% of these cancers contained structural alterations of this gene, whereas only 45% of these cases overexpressed p53 by immunohistochemical analysis. Finally, both Northern blot and immunohistochemical analysis showed that these tumors exhibited changes in the mRNA and protein expression levels respectively of the immediate early transcription factor genes c-fos, c-jun, and EGR, in that less expression of these genes was evident in the tumors compared with adjacent normal tissue. Understanding both the biologic and molecular significance of these findings may allow us to explore novel modalities for treatment of this disease.</description><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Clinical Trials as Topic</subject><subject>Gene Expression</subject><subject>Genes, fos - genetics</subject><subject>Genes, jun - genetics</subject><subject>Genes, p53 - genetics</subject><subject>Genes, Tumor Suppressor</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lung Neoplasms - genetics</subject><subject>Multicenter Studies as Topic</subject><subject>Mutation</subject><subject>Randomized Controlled Trials as Topic</subject><subject>RNA Probes</subject><subject>Sequence Analysis, DNA</subject><subject>Transcription, Genetic</subject><issn>0012-3692</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1PwzAQxT2ASinsLEie2FLsOLWTEVV8SZUYKCOyLs6lBCVO8CVD_3tcWrHc3dO9ezr9GLuRYimVye_dF9K4lEIv9VKZlM7YXAiZJkoX6QW7JPoWUctCz9jMFHmeajNnn9up6wOnaRgCEsURfMWbrsOqgRE5Qmj3fAzgyYVmGJve8xrcGI079Ei88dz3PqEO2pY7jKWd_I478A7DFTuvoSW8PvUF-3h63K5fks3b8-v6YZO4VBRjoqsCAVelQFGJGkSpVy5zQoLKaoNGmjwvDcBKaQeVqguBVSYwTfPSZXFVqgW7O-YOof-ZIgbbNXR4Bjz2E1mjc13EmGgUR6MLPVHA2g6h6SDsrRT2QNH-UYxKW20jxfd4cnvKnspI5f_ghFD9AtIDc6c</recordid><startdate>199412</startdate><enddate>199412</enddate><creator>Levin, W J</creator><creator>Casey, G</creator><creator>Ramos, J C</creator><creator>Arboleda, M J</creator><creator>Reissmann, P T</creator><creator>Slamon, D J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199412</creationdate><title>Tumor suppressor and immediate early transcription factor genes in non-small cell lung cancer</title><author>Levin, W J ; Casey, G ; Ramos, J C ; Arboleda, M J ; Reissmann, P T ; Slamon, D J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c209t-6d9eae5b0e0d0fa0b65c4c01a34f7e71788b7aa536cad3f90ed40e228bc488bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Clinical Trials as Topic</topic><topic>Gene Expression</topic><topic>Genes, fos - genetics</topic><topic>Genes, jun - genetics</topic><topic>Genes, p53 - genetics</topic><topic>Genes, Tumor Suppressor</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lung Neoplasms - genetics</topic><topic>Multicenter Studies as Topic</topic><topic>Mutation</topic><topic>Randomized Controlled Trials as Topic</topic><topic>RNA Probes</topic><topic>Sequence Analysis, DNA</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levin, W J</creatorcontrib><creatorcontrib>Casey, G</creatorcontrib><creatorcontrib>Ramos, J C</creatorcontrib><creatorcontrib>Arboleda, M J</creatorcontrib><creatorcontrib>Reissmann, P T</creatorcontrib><creatorcontrib>Slamon, D J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levin, W J</au><au>Casey, G</au><au>Ramos, J C</au><au>Arboleda, M J</au><au>Reissmann, P T</au><au>Slamon, D J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor suppressor and immediate early transcription factor genes in non-small cell lung cancer</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1994-12</date><risdate>1994</risdate><volume>106</volume><issue>6 Suppl</issue><spage>372S</spage><epage>376</epage><pages>372S-376</pages><issn>0012-3692</issn><abstract>Non-small lung cancer (NSCLC) is a disease that exhibits multiple genetic lesions. Lung Cancer Study Group (LCSG) 871 was designed to analyze this group of malignancies for alterations in growth factors and/or their receptors, oncogenes, tumor suppressor genes, and immediate early transcription factor genes. Immunohistochemical analysis showed that 32% of evaluable cases studied contained absent or abnormal Rb expression. Sequence analysis of the p53 gene revealed that 58% of these cancers contained structural alterations of this gene, whereas only 45% of these cases overexpressed p53 by immunohistochemical analysis. Finally, both Northern blot and immunohistochemical analysis showed that these tumors exhibited changes in the mRNA and protein expression levels respectively of the immediate early transcription factor genes c-fos, c-jun, and EGR, in that less expression of these genes was evident in the tumors compared with adjacent normal tissue. Understanding both the biologic and molecular significance of these findings may allow us to explore novel modalities for treatment of this disease.</abstract><cop>United States</cop><pmid>7988267</pmid><doi>10.1378/chest.106.6.372s</doi><tpages>5</tpages></addata></record> |
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| ispartof | Chest, 1994-12, Vol.106 (6 Suppl), p.372S-376 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Carcinoma, Non-Small-Cell Lung - genetics Clinical Trials as Topic Gene Expression Genes, fos - genetics Genes, jun - genetics Genes, p53 - genetics Genes, Tumor Suppressor Humans Immunohistochemistry Lung Neoplasms - genetics Multicenter Studies as Topic Mutation Randomized Controlled Trials as Topic RNA Probes Sequence Analysis, DNA Transcription, Genetic |
| title | Tumor suppressor and immediate early transcription factor genes in non-small cell lung cancer |
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