Monoclonal antibodies in oncology
Monoclonal antibodies (MCAs) can be used to differentiate between normal and neoplastic cells and thus exploited for diagnostic and, ultimately, therapeutic gain. The evidence for the existence of human tumour antigens is reviewed. Several areas of diagnosis are already benefiting from the applicati...
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| Veröffentlicht in: | Radiotherapy and oncology 1986-05, Vol.6 (1), p.1-14 |
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| container_title | Radiotherapy and oncology |
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| creator | Chan, Stephen Y.T. Sikora, Karol |
| description | Monoclonal antibodies (MCAs) can be used to differentiate between normal and neoplastic cells and thus exploited for diagnostic and, ultimately, therapeutic gain. The evidence for the existence of human tumour antigens is reviewed. Several areas of diagnosis are already benefiting from the application of the moncolonal technology. Immunohistology can help the pathologist with difficult diagnostic problems. New classifications of lymphoma and leukaemia can be based on specific surface molecules. Similarly, the detection of shed tumour antigens is already established as part of the routine assessment of many patients with common solid tumours. Isotopically labelled monoclonal antibodies have been used to localise primary and metastatic tumours. The use of antibodies in this way is not only a promising diagnostic tool but also the first step in studying the possibility of arming antibodies to provide therapeutic agents. Such trials are currently in progress. |
| doi_str_mv | 10.1016/S0167-8140(86)80105-0 |
| format | Article |
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Such trials are currently in progress.</description><identifier>ISSN: 0167-8140</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/S0167-8140(86)80105-0</identifier><identifier>PMID: 3520697</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Antibodies, Monoclonal - therapeutic use ; Antigens, Neoplasm - immunology ; Antineoplastic Agents - therapeutic use ; Bone Marrow Transplantation ; Humans ; Hybridomas - immunology ; Immunotherapy ; Mice ; Middle Aged ; Monoclonal antibodies ; Neoplasms - diagnosis ; Neoplasms - drug therapy ; Neoplasms - immunology ; Neoplasms - pathology ; Neoplasms - radiotherapy ; Neoplasms - therapy ; Toxins, Biological - therapeutic use ; Tumour localization ; Tumour markers</subject><ispartof>Radiotherapy and oncology, 1986-05, Vol.6 (1), p.1-14</ispartof><rights>1986 Elsevier Science Publishers B.V. 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Such trials are currently in progress.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Antigens, Neoplasm - immunology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Bone Marrow Transplantation</subject><subject>Humans</subject><subject>Hybridomas - immunology</subject><subject>Immunotherapy</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Neoplasms - diagnosis</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - radiotherapy</subject><subject>Neoplasms - therapy</subject><subject>Toxins, Biological - therapeutic use</subject><subject>Tumour localization</subject><subject>Tumour markers</subject><issn>0167-8140</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LAzEQxYMotVb_hEK9iB5WJ5tukj2JFL-g4kE9h2wyK5FtUpOt0P_e9AOvXmYO7_dmeI-QMYVrCpTfvOUhCkmncCn5lQQKVQEHZEilqAuQUhyS4R9yTE5S-gKAEpgYkAGrSuC1GJLzl-CD6YLX3UT73jXBOkwT5yfBm9CFz_UpOWp1l_Bsv0fk4-H-ffZUzF8fn2d388IwDn3RYkNZo-20NLTlJWMl4ygb3jBsLdUtq1vUUy4qFKyWumJScl6JjGfCZnpELnZ3lzF8rzD1auGSwa7THsMqKcElF7WQGax2oIkhpYitWka30HGtKKhNNWpbjdrkVpKrbTUKsm-8f7BqFmj_XPsusn670zGn_HEYVTIOvUHrIppe2eD--fALTFBx7w</recordid><startdate>19860501</startdate><enddate>19860501</enddate><creator>Chan, Stephen Y.T.</creator><creator>Sikora, Karol</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860501</creationdate><title>Monoclonal antibodies in oncology</title><author>Chan, Stephen Y.T. ; Sikora, Karol</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-feb13bad42c1f6233236e8b6b3efd1af39fea4675e7398a5388665742cb3ed323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Antigens, Neoplasm - immunology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Bone Marrow Transplantation</topic><topic>Humans</topic><topic>Hybridomas - immunology</topic><topic>Immunotherapy</topic><topic>Mice</topic><topic>Middle Aged</topic><topic>Monoclonal antibodies</topic><topic>Neoplasms - diagnosis</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - radiotherapy</topic><topic>Neoplasms - therapy</topic><topic>Toxins, Biological - therapeutic use</topic><topic>Tumour localization</topic><topic>Tumour markers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chan, Stephen Y.T.</creatorcontrib><creatorcontrib>Sikora, Karol</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chan, Stephen Y.T.</au><au>Sikora, Karol</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monoclonal antibodies in oncology</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>1986-05-01</date><risdate>1986</risdate><volume>6</volume><issue>1</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>0167-8140</issn><eissn>1879-0887</eissn><abstract>Monoclonal antibodies (MCAs) can be used to differentiate between normal and neoplastic cells and thus exploited for diagnostic and, ultimately, therapeutic gain. 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| fulltext | fulltext |
| identifier | ISSN: 0167-8140 |
| ispartof | Radiotherapy and oncology, 1986-05, Vol.6 (1), p.1-14 |
| issn | 0167-8140 1879-0887 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antibodies, Monoclonal - therapeutic use Antigens, Neoplasm - immunology Antineoplastic Agents - therapeutic use Bone Marrow Transplantation Humans Hybridomas - immunology Immunotherapy Mice Middle Aged Monoclonal antibodies Neoplasms - diagnosis Neoplasms - drug therapy Neoplasms - immunology Neoplasms - pathology Neoplasms - radiotherapy Neoplasms - therapy Toxins, Biological - therapeutic use Tumour localization Tumour markers |
| title | Monoclonal antibodies in oncology |
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