Growth inhibition of Trypanosoma cruzi and Leishmania donovani infantum by different snake venoms: Preliminary identification of proteins from Cerastes cerastes venom which interact with the parasites
Venom from three different snake species was tested in vitro against the protozoan parasites Trypanosoma cruzi and Leishmania ddonovani infantum. Two of them, Cerastes cerastes and Naja haje, exerted a significant growth inhibition of T. cruzi and L. d. infantum parasites. Heating of the venoms abol...
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| Veröffentlicht in: | Toxicon (Oxford) 1994-08, Vol.32 (8), p.875-882 |
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| container_title | Toxicon (Oxford) |
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| creator | Fernandez-Gomez, Rodolfo Zerrouk, Halim Sebti, Fatima Loyens, Marc Benslimane, Abdallah Ouaissi, M.Ali |
| description | Venom from three different snake species was tested
in vitro against the protozoan parasites
Trypanosoma cruzi and
Leishmania ddonovani infantum. Two of them,
Cerastes cerastes and
Naja haje, exerted a significant growth inhibition of
T. cruzi and
L. d. infantum parasites. Heating of the venoms abolished their activity, suggesting that the active factors are thermolabile. Incubation of parasites with
125I-labelled
C. cerastes venom proteins allowed preliminary identification of components which interact preferentially with the pathogens. |
| doi_str_mv | 10.1016/0041-0101(94)90366-2 |
| format | Article |
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in vitro against the protozoan parasites
Trypanosoma cruzi and
Leishmania ddonovani infantum. Two of them,
Cerastes cerastes and
Naja haje, exerted a significant growth inhibition of
T. cruzi and
L. d. infantum parasites. Heating of the venoms abolished their activity, suggesting that the active factors are thermolabile. Incubation of parasites with
125I-labelled
C. cerastes venom proteins allowed preliminary identification of components which interact preferentially with the pathogens.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/0041-0101(94)90366-2</identifier><identifier>PMID: 7985193</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Autoradiography ; Biological and medical sciences ; Culture Media ; Elapid Venoms - chemistry ; Elapid Venoms - pharmacology ; Elapidae ; Electrophoresis, Polyacrylamide Gel ; General pharmacology ; Leishmania donovani ; Leishmania donovani - drug effects ; Leishmania donovani - growth & development ; Medical sciences ; Naja haje ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Proteins - analysis ; Temperature ; Trypanosoma cruzi ; Trypanosoma cruzi - drug effects ; Trypanosoma cruzi - growth & development ; Viper Venoms - chemistry ; Viper Venoms - pharmacology ; Viperidae</subject><ispartof>Toxicon (Oxford), 1994-08, Vol.32 (8), p.875-882</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-571f2b1685106812b1ed77ef7a433601912684ac9833c9b3e29e88a660d2f783</citedby><cites>FETCH-LOGICAL-c417t-571f2b1685106812b1ed77ef7a433601912684ac9833c9b3e29e88a660d2f783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0041-0101(94)90366-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4145407$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7985193$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernandez-Gomez, Rodolfo</creatorcontrib><creatorcontrib>Zerrouk, Halim</creatorcontrib><creatorcontrib>Sebti, Fatima</creatorcontrib><creatorcontrib>Loyens, Marc</creatorcontrib><creatorcontrib>Benslimane, Abdallah</creatorcontrib><creatorcontrib>Ouaissi, M.Ali</creatorcontrib><title>Growth inhibition of Trypanosoma cruzi and Leishmania donovani infantum by different snake venoms: Preliminary identification of proteins from Cerastes cerastes venom which interact with the parasites</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>Venom from three different snake species was tested
in vitro against the protozoan parasites
Trypanosoma cruzi and
Leishmania ddonovani infantum. Two of them,
Cerastes cerastes and
Naja haje, exerted a significant growth inhibition of
T. cruzi and
L. d. infantum parasites. Heating of the venoms abolished their activity, suggesting that the active factors are thermolabile. Incubation of parasites with
125I-labelled
C. cerastes venom proteins allowed preliminary identification of components which interact preferentially with the pathogens.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Culture Media</subject><subject>Elapid Venoms - chemistry</subject><subject>Elapid Venoms - pharmacology</subject><subject>Elapidae</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>General pharmacology</subject><subject>Leishmania donovani</subject><subject>Leishmania donovani - drug effects</subject><subject>Leishmania donovani - growth & development</subject><subject>Medical sciences</subject><subject>Naja haje</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Proteins - analysis</subject><subject>Temperature</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - drug effects</subject><subject>Trypanosoma cruzi - growth & development</subject><subject>Viper Venoms - chemistry</subject><subject>Viper Venoms - pharmacology</subject><subject>Viperidae</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2OEzEQhVsINAwDNwDJC4Rg0WB3u_3DAglFMCBFgkX2luMuKwVpO9hOonBCjoUzyWQJKz-5vio_12ua54y-ZZSJd5Ry1tIqX2v-RtNeiLZ70FwzJXXbs4E-bK4vyOPmSc4_KKW90uKquZJaDUz3182f2xT3ZUUwrHCJBWMg0ZNFOmxsiDlOlri0_Y3EhpHMAfNqsgEtGWOIu6pqn7ehbCeyPJARvYcEoZAc7E8gOwhxyu_J9wRrnDDYdCA41jp6dPb-rU2KBTBk4lOcyAySzQUycffibgrZr9AdXZZ67QrZY_VcVkA2tmJYuafNI2_XGZ6dz5tm8fnTYvalnX-7_Tr7OG8dZ7K0g2S-WzJRv0-FYlXCKCV4aXnfC8o064Ti1mnV904ve-g0KGWFoGPnpepvmlensdX2ry3kYibMDtZrGyBus5FCCTlI-l-QCS37QfEK8hPoUsw5gTebhFPdlWHUHIM2xxTNMUWjubkL2nS17cV5_nY5wXhpOidb6y_PdZudXftkg8N8wTjjA6eyYh9OGNSd7RCSyQ4hOBgxgStmjPhvH38B1XjI2w</recordid><startdate>19940801</startdate><enddate>19940801</enddate><creator>Fernandez-Gomez, Rodolfo</creator><creator>Zerrouk, Halim</creator><creator>Sebti, Fatima</creator><creator>Loyens, Marc</creator><creator>Benslimane, Abdallah</creator><creator>Ouaissi, M.Ali</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19940801</creationdate><title>Growth inhibition of Trypanosoma cruzi and Leishmania donovani infantum by different snake venoms: Preliminary identification of proteins from Cerastes cerastes venom which interact with the parasites</title><author>Fernandez-Gomez, Rodolfo ; Zerrouk, Halim ; Sebti, Fatima ; Loyens, Marc ; Benslimane, Abdallah ; Ouaissi, M.Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-571f2b1685106812b1ed77ef7a433601912684ac9833c9b3e29e88a660d2f783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Autoradiography</topic><topic>Biological and medical sciences</topic><topic>Culture Media</topic><topic>Elapid Venoms - chemistry</topic><topic>Elapid Venoms - pharmacology</topic><topic>Elapidae</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>General pharmacology</topic><topic>Leishmania donovani</topic><topic>Leishmania donovani - drug effects</topic><topic>Leishmania donovani - growth & development</topic><topic>Medical sciences</topic><topic>Naja haje</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Proteins - analysis</topic><topic>Temperature</topic><topic>Trypanosoma cruzi</topic><topic>Trypanosoma cruzi - drug effects</topic><topic>Trypanosoma cruzi - growth & development</topic><topic>Viper Venoms - chemistry</topic><topic>Viper Venoms - pharmacology</topic><topic>Viperidae</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernandez-Gomez, Rodolfo</creatorcontrib><creatorcontrib>Zerrouk, Halim</creatorcontrib><creatorcontrib>Sebti, Fatima</creatorcontrib><creatorcontrib>Loyens, Marc</creatorcontrib><creatorcontrib>Benslimane, Abdallah</creatorcontrib><creatorcontrib>Ouaissi, M.Ali</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernandez-Gomez, Rodolfo</au><au>Zerrouk, Halim</au><au>Sebti, Fatima</au><au>Loyens, Marc</au><au>Benslimane, Abdallah</au><au>Ouaissi, M.Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth inhibition of Trypanosoma cruzi and Leishmania donovani infantum by different snake venoms: Preliminary identification of proteins from Cerastes cerastes venom which interact with the parasites</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>1994-08-01</date><risdate>1994</risdate><volume>32</volume><issue>8</issue><spage>875</spage><epage>882</epage><pages>875-882</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>Venom from three different snake species was tested
in vitro against the protozoan parasites
Trypanosoma cruzi and
Leishmania ddonovani infantum. Two of them,
Cerastes cerastes and
Naja haje, exerted a significant growth inhibition of
T. cruzi and
L. d. infantum parasites. Heating of the venoms abolished their activity, suggesting that the active factors are thermolabile. Incubation of parasites with
125I-labelled
C. cerastes venom proteins allowed preliminary identification of components which interact preferentially with the pathogens.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>7985193</pmid><doi>10.1016/0041-0101(94)90366-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Toxicon (Oxford), 1994-08, Vol.32 (8), p.875-882 |
| issn | 0041-0101 1879-3150 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Autoradiography Biological and medical sciences Culture Media Elapid Venoms - chemistry Elapid Venoms - pharmacology Elapidae Electrophoresis, Polyacrylamide Gel General pharmacology Leishmania donovani Leishmania donovani - drug effects Leishmania donovani - growth & development Medical sciences Naja haje Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Proteins - analysis Temperature Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - growth & development Viper Venoms - chemistry Viper Venoms - pharmacology Viperidae |
| title | Growth inhibition of Trypanosoma cruzi and Leishmania donovani infantum by different snake venoms: Preliminary identification of proteins from Cerastes cerastes venom which interact with the parasites |
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