QUANTITATIVE CHANGES IN THE RAT PULMONARY VASCULATURE IN CHRONIC HYPOXIA - RELATION TO HAEMODYNAMIC CHANGES
The anatomical basis of resistance and compliance changes of the pulmonary arterial bed was studied in rats exposed to chronic hypoxia (10% O 2 , 3 weeks) and the findings were compared with those of normoxic rats. The lungs were perfused with a Ba-gelatine mixture at different pressures and studied...
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| Veröffentlicht in: | Experimental physiology 1986-04, Vol.71 (2), p.151-163 |
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| creator | Finlay, Michael Barer, Gwenda R. Suggett, Andrew J. |
| description | The anatomical basis of resistance and compliance changes of the pulmonary arterial bed was studied in rats exposed to chronic
hypoxia (10% O 2 , 3 weeks) and the findings were compared with those of normoxic rats. The lungs were perfused with a Ba-gelatine mixture
at different pressures and studied by radiology and histology. The diameter of the pulmonary arteries (ã 0·5 mm), measured
from X-rays, was less in chronically hypoxic than normoxic rats when filled at the same perfusion pressure. Diameters increased
in both groups with increasing perfusion pressure but at a given pressure those of chronically hypoxic rats were always smaller
than those of normoxic rats. We found evidence that arterial length was increased in chronically hypoxic rats. Arterioles
of 50 µm or less in diameter adjacent to gas exchange units were of similar external diameter in normoxic and chronically
hypoxic rats, but most of the latter had developed a muscular coat and a second elastic lamina internal to the single elastic
lamina of control arterioles. These changes reduced the lumen by an estimated 10-14% and would increase pulmonary arteriolar
resistance in chronically hypoxic rats, resulting in a changed pressure profile. We found no evidence of arteriolar loss in
chronically hypoxic rats although at a given pressure, the Ba-gelatine mixture penetrated less far for reasons which are discussed. |
| doi_str_mv | 10.1113/expphysiol.1986.sp002975 |
| format | Article |
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hypoxia (10% O 2 , 3 weeks) and the findings were compared with those of normoxic rats. The lungs were perfused with a Ba-gelatine mixture
at different pressures and studied by radiology and histology. The diameter of the pulmonary arteries (ã 0·5 mm), measured
from X-rays, was less in chronically hypoxic than normoxic rats when filled at the same perfusion pressure. Diameters increased
in both groups with increasing perfusion pressure but at a given pressure those of chronically hypoxic rats were always smaller
than those of normoxic rats. We found evidence that arterial length was increased in chronically hypoxic rats. Arterioles
of 50 µm or less in diameter adjacent to gas exchange units were of similar external diameter in normoxic and chronically
hypoxic rats, but most of the latter had developed a muscular coat and a second elastic lamina internal to the single elastic
lamina of control arterioles. These changes reduced the lumen by an estimated 10-14% and would increase pulmonary arteriolar
resistance in chronically hypoxic rats, resulting in a changed pressure profile. We found no evidence of arteriolar loss in
chronically hypoxic rats although at a given pressure, the Ba-gelatine mixture penetrated less far for reasons which are discussed.</description><identifier>ISSN: 0958-0670</identifier><identifier>ISSN: 0144-8757</identifier><identifier>EISSN: 1469-445X</identifier><identifier>DOI: 10.1113/expphysiol.1986.sp002975</identifier><identifier>PMID: 3714956</identifier><identifier>CODEN: QJEPD3</identifier><language>eng</language><publisher>Cambridge: The Physiological Society</publisher><subject>Air breathing ; Angiography ; Animals ; Arteries - pathology ; Barium ; Biological and medical sciences ; Chronic Disease ; Fundamental and applied biological sciences. Psychology ; Hemodynamics ; Hypoxia - diagnostic imaging ; Hypoxia - pathology ; Hypoxia - physiopathology ; Male ; Pulmonary Circulation ; Rats ; Rats, Inbred Strains ; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics ; Vertebrates: respiratory system</subject><ispartof>Experimental physiology, 1986-04, Vol.71 (2), p.151-163</ispartof><rights>1986 The Physiological Society</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3951-a968bbef1e2851b2d5bfdb6d5156110193fd2e6b94a7382dd84da54639a174e43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7883386$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3714956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Finlay, Michael</creatorcontrib><creatorcontrib>Barer, Gwenda R.</creatorcontrib><creatorcontrib>Suggett, Andrew J.</creatorcontrib><title>QUANTITATIVE CHANGES IN THE RAT PULMONARY VASCULATURE IN CHRONIC HYPOXIA - RELATION TO HAEMODYNAMIC CHANGES</title><title>Experimental physiology</title><addtitle>Q J Exp Physiol</addtitle><description>The anatomical basis of resistance and compliance changes of the pulmonary arterial bed was studied in rats exposed to chronic
hypoxia (10% O 2 , 3 weeks) and the findings were compared with those of normoxic rats. The lungs were perfused with a Ba-gelatine mixture
at different pressures and studied by radiology and histology. The diameter of the pulmonary arteries (ã 0·5 mm), measured
from X-rays, was less in chronically hypoxic than normoxic rats when filled at the same perfusion pressure. Diameters increased
in both groups with increasing perfusion pressure but at a given pressure those of chronically hypoxic rats were always smaller
than those of normoxic rats. We found evidence that arterial length was increased in chronically hypoxic rats. Arterioles
of 50 µm or less in diameter adjacent to gas exchange units were of similar external diameter in normoxic and chronically
hypoxic rats, but most of the latter had developed a muscular coat and a second elastic lamina internal to the single elastic
lamina of control arterioles. These changes reduced the lumen by an estimated 10-14% and would increase pulmonary arteriolar
resistance in chronically hypoxic rats, resulting in a changed pressure profile. We found no evidence of arteriolar loss in
chronically hypoxic rats although at a given pressure, the Ba-gelatine mixture penetrated less far for reasons which are discussed.</description><subject>Air breathing</subject><subject>Angiography</subject><subject>Animals</subject><subject>Arteries - pathology</subject><subject>Barium</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemodynamics</subject><subject>Hypoxia - diagnostic imaging</subject><subject>Hypoxia - pathology</subject><subject>Hypoxia - physiopathology</subject><subject>Male</subject><subject>Pulmonary Circulation</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Vertebrates: respiratory system</subject><issn>0958-0670</issn><issn>0144-8757</issn><issn>1469-445X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9vm0AQxVHVKnXTfoRKe6h6w91h2WX3uKI0INngEoji04o_S02LA2Vjpf72BZkm155Gmvd78zTPshDgNQCQL_rPMBzOpu27NQjO1mbA2BEefWWtwGXCdl16_9paYUG5jZmH31rvjPmJMRDM3SvrinjgCspW1q_vuYyzKJNZdBcgP5TxTXCLohhlYYBSmaFdvtkmsUz36E7e-vlGZnkazIAfpkkc-Sjc75L7SCIbpcGkRsnkTVAog23ydR_L7YQsZ99bb5qiM_rDMq-t_FuQ-aG9SW4iX27siggKdiEYL0vdgHY4hdKpadnUJaspUAaAQZCmdjQrhVt4hDt1zd26oC4jogDP1S65tj5f7g5j__ukzaM6tqbSXVc86P5klMc4YwQ7E8gvYDX2xoy6UcPYHovxrACruWf10rOae1b_ep6sH5eMU3nU9bNxKXbSPy16Yaqia8bioWrNM-ZxTgifMf-CPbWdPv93vAp24bzwwAEKLw8f2h-Hp3bU6uIyfdXqxykNlKNm8C9aXqPr</recordid><startdate>19860407</startdate><enddate>19860407</enddate><creator>Finlay, Michael</creator><creator>Barer, Gwenda R.</creator><creator>Suggett, Andrew J.</creator><general>The Physiological Society</general><general>Cambridge University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860407</creationdate><title>QUANTITATIVE CHANGES IN THE RAT PULMONARY VASCULATURE IN CHRONIC HYPOXIA - RELATION TO HAEMODYNAMIC CHANGES</title><author>Finlay, Michael ; Barer, Gwenda R. ; Suggett, Andrew J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3951-a968bbef1e2851b2d5bfdb6d5156110193fd2e6b94a7382dd84da54639a174e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Air breathing</topic><topic>Angiography</topic><topic>Animals</topic><topic>Arteries - pathology</topic><topic>Barium</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemodynamics</topic><topic>Hypoxia - diagnostic imaging</topic><topic>Hypoxia - pathology</topic><topic>Hypoxia - physiopathology</topic><topic>Male</topic><topic>Pulmonary Circulation</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Finlay, Michael</creatorcontrib><creatorcontrib>Barer, Gwenda R.</creatorcontrib><creatorcontrib>Suggett, Andrew J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Finlay, Michael</au><au>Barer, Gwenda R.</au><au>Suggett, Andrew J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>QUANTITATIVE CHANGES IN THE RAT PULMONARY VASCULATURE IN CHRONIC HYPOXIA - RELATION TO HAEMODYNAMIC CHANGES</atitle><jtitle>Experimental physiology</jtitle><addtitle>Q J Exp Physiol</addtitle><date>1986-04-07</date><risdate>1986</risdate><volume>71</volume><issue>2</issue><spage>151</spage><epage>163</epage><pages>151-163</pages><issn>0958-0670</issn><issn>0144-8757</issn><eissn>1469-445X</eissn><coden>QJEPD3</coden><abstract>The anatomical basis of resistance and compliance changes of the pulmonary arterial bed was studied in rats exposed to chronic
hypoxia (10% O 2 , 3 weeks) and the findings were compared with those of normoxic rats. The lungs were perfused with a Ba-gelatine mixture
at different pressures and studied by radiology and histology. The diameter of the pulmonary arteries (ã 0·5 mm), measured
from X-rays, was less in chronically hypoxic than normoxic rats when filled at the same perfusion pressure. Diameters increased
in both groups with increasing perfusion pressure but at a given pressure those of chronically hypoxic rats were always smaller
than those of normoxic rats. We found evidence that arterial length was increased in chronically hypoxic rats. Arterioles
of 50 µm or less in diameter adjacent to gas exchange units were of similar external diameter in normoxic and chronically
hypoxic rats, but most of the latter had developed a muscular coat and a second elastic lamina internal to the single elastic
lamina of control arterioles. These changes reduced the lumen by an estimated 10-14% and would increase pulmonary arteriolar
resistance in chronically hypoxic rats, resulting in a changed pressure profile. We found no evidence of arteriolar loss in
chronically hypoxic rats although at a given pressure, the Ba-gelatine mixture penetrated less far for reasons which are discussed.</abstract><cop>Cambridge</cop><pub>The Physiological Society</pub><pmid>3714956</pmid><doi>10.1113/expphysiol.1986.sp002975</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0958-0670 |
| ispartof | Experimental physiology, 1986-04, Vol.71 (2), p.151-163 |
| issn | 0958-0670 0144-8757 1469-445X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76866302 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Air breathing Angiography Animals Arteries - pathology Barium Biological and medical sciences Chronic Disease Fundamental and applied biological sciences. Psychology Hemodynamics Hypoxia - diagnostic imaging Hypoxia - pathology Hypoxia - physiopathology Male Pulmonary Circulation Rats Rats, Inbred Strains Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Vertebrates: respiratory system |
| title | QUANTITATIVE CHANGES IN THE RAT PULMONARY VASCULATURE IN CHRONIC HYPOXIA - RELATION TO HAEMODYNAMIC CHANGES |
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