Analysis of the hepatobiliary transport of IgA with monoclonal anti-idiotype and anti-allotype antibodies
The processing and fate of mixed immune complexes is influenced by the antibody isotypes present. The hepatobiliary transport of mixed immune complexes containing the mouse IgA myeloma protein J558 and corresponding monoclonal IgG or IgM anti-J558 idiotype or monoclonal IgG anti-mouse IgA allotype a...
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| Veröffentlicht in: | Molecular immunology 1986-03, Vol.23 (3), p.339-346 |
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| container_title | Molecular immunology |
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| creator | Phillips, John O. Stohrer, Robert Russell, Michael W. Brown, Thomas A. Epps, J.Miller Kearney, John F. Mestecky, Jiri |
| description | The processing and fate of mixed immune complexes is influenced by the antibody isotypes present. The hepatobiliary transport of mixed immune complexes containing the mouse IgA myeloma protein J558 and corresponding monoclonal IgG or IgM anti-J558 idiotype or monoclonal IgG anti-mouse IgA allotype antibodies has been studied. The anti-idiotype or anti-allotype antibodies were radiolabeled and injected into mice with or without mouse polymeric IgA (J558). IgG anti-idiotype antibodies to J558 IgA were selectively transported into bile by J558 IgA. This process occurred with a radiolabeled Fab preparation of the IgG anti-idiotype and was inhibitable with IgA of an irrelevant antigenic specificity. Thus, polymeric IgA influenced the fate of IgA-IgG idiotype-anti-idiotype serum immune complexes. A monoclonal anti-idiotype antibody of the IgM isotype (D8-3) was not selectively transported into bile by itself or as an IgA-IgM complex. A monoclonal IgG antibody (CB5-6) to a mouse allotype determinant in the Fc portion of IgA was not selectively transported into bile. This anti-allotype monoclonal antibody inhibited the hepatobiliary transport of
125I-polymeric J558 IgA and therefore appeared to directly or indirectly block the site in the Fc region of IgA recognized by the hepatic receptor. |
| doi_str_mv | 10.1016/0161-5890(86)90061-1 |
| format | Article |
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125I-polymeric J558 IgA and therefore appeared to directly or indirectly block the site in the Fc region of IgA recognized by the hepatic receptor.</description><identifier>ISSN: 0161-5890</identifier><identifier>EISSN: 1872-9142</identifier><identifier>DOI: 10.1016/0161-5890(86)90061-1</identifier><identifier>PMID: 3713709</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Antibodies, Monoclonal - immunology ; Antigen-Antibody Complex - metabolism ; Bile - metabolism ; Biological Transport ; Immunoglobulin A - immunology ; Immunoglobulin A - metabolism ; Immunoglobulin Allotypes - immunology ; Immunoglobulin Fab Fragments - immunology ; Immunoglobulin Idiotypes - immunology ; Immunoglobulin M - immunology ; Liver - metabolism ; Mice ; Mice, Inbred Strains</subject><ispartof>Molecular immunology, 1986-03, Vol.23 (3), p.339-346</ispartof><rights>1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c303t-7a394130169ac049bea6bba830b7341f609862d6307a12878afe1eeffb6346a73</citedby><cites>FETCH-LOGICAL-c303t-7a394130169ac049bea6bba830b7341f609862d6307a12878afe1eeffb6346a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0161589086900611$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3713709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Phillips, John O.</creatorcontrib><creatorcontrib>Stohrer, Robert</creatorcontrib><creatorcontrib>Russell, Michael W.</creatorcontrib><creatorcontrib>Brown, Thomas A.</creatorcontrib><creatorcontrib>Epps, J.Miller</creatorcontrib><creatorcontrib>Kearney, John F.</creatorcontrib><creatorcontrib>Mestecky, Jiri</creatorcontrib><title>Analysis of the hepatobiliary transport of IgA with monoclonal anti-idiotype and anti-allotype antibodies</title><title>Molecular immunology</title><addtitle>Mol Immunol</addtitle><description>The processing and fate of mixed immune complexes is influenced by the antibody isotypes present. The hepatobiliary transport of mixed immune complexes containing the mouse IgA myeloma protein J558 and corresponding monoclonal IgG or IgM anti-J558 idiotype or monoclonal IgG anti-mouse IgA allotype antibodies has been studied. The anti-idiotype or anti-allotype antibodies were radiolabeled and injected into mice with or without mouse polymeric IgA (J558). IgG anti-idiotype antibodies to J558 IgA were selectively transported into bile by J558 IgA. This process occurred with a radiolabeled Fab preparation of the IgG anti-idiotype and was inhibitable with IgA of an irrelevant antigenic specificity. Thus, polymeric IgA influenced the fate of IgA-IgG idiotype-anti-idiotype serum immune complexes. A monoclonal anti-idiotype antibody of the IgM isotype (D8-3) was not selectively transported into bile by itself or as an IgA-IgM complex. A monoclonal IgG antibody (CB5-6) to a mouse allotype determinant in the Fc portion of IgA was not selectively transported into bile. This anti-allotype monoclonal antibody inhibited the hepatobiliary transport of
125I-polymeric J558 IgA and therefore appeared to directly or indirectly block the site in the Fc region of IgA recognized by the hepatic receptor.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigen-Antibody Complex - metabolism</subject><subject>Bile - metabolism</subject><subject>Biological Transport</subject><subject>Immunoglobulin A - immunology</subject><subject>Immunoglobulin A - metabolism</subject><subject>Immunoglobulin Allotypes - immunology</subject><subject>Immunoglobulin Fab Fragments - immunology</subject><subject>Immunoglobulin Idiotypes - immunology</subject><subject>Immunoglobulin M - immunology</subject><subject>Liver - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><issn>0161-5890</issn><issn>1872-9142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEUhYMotVb_gcKsRBejySTNYyOU4qNQcKPrkJm5YyPTyZikSv-9qa1d6iKEe885N-G7CJ0TfEMw4bfpkHwsFb6S_FphnCpygIZEiiJXhBWHaLi3HKOTEN5xMmE-HqABFYQKrIbITjrTroMNmWuyuIBsAb2JrrStNX6dRW-60DsfN_LsbZJ92bjIlq5zVetSMjNdtLmtrYvrHlJVbzumbX870ZauthBO0VFj2gBnu3uEXh_uX6ZP-fz5cTadzPOKYhpzYahihKafK1NhpkowvCyNpLgUlJGGYyV5UXOKhSGFFNI0QACapuSUcSPoCF1u5_befawgRL20oYK2NR24VdCCS86KsfrXSJgaC8lwMrKtsfIuBA-N7r1dJjyaYL1Zhd5w1hvOWnL9swpNUuxiN39VLqHeh3bsk3631SHR-LTgdagsdBXU1kMVde3s3w98Axx6mNk</recordid><startdate>198603</startdate><enddate>198603</enddate><creator>Phillips, John O.</creator><creator>Stohrer, Robert</creator><creator>Russell, Michael W.</creator><creator>Brown, Thomas A.</creator><creator>Epps, J.Miller</creator><creator>Kearney, John F.</creator><creator>Mestecky, Jiri</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198603</creationdate><title>Analysis of the hepatobiliary transport of IgA with monoclonal anti-idiotype and anti-allotype antibodies</title><author>Phillips, John O. ; Stohrer, Robert ; Russell, Michael W. ; Brown, Thomas A. ; Epps, J.Miller ; Kearney, John F. ; Mestecky, Jiri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c303t-7a394130169ac049bea6bba830b7341f609862d6307a12878afe1eeffb6346a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigen-Antibody Complex - metabolism</topic><topic>Bile - metabolism</topic><topic>Biological Transport</topic><topic>Immunoglobulin A - immunology</topic><topic>Immunoglobulin A - metabolism</topic><topic>Immunoglobulin Allotypes - immunology</topic><topic>Immunoglobulin Fab Fragments - immunology</topic><topic>Immunoglobulin Idiotypes - immunology</topic><topic>Immunoglobulin M - immunology</topic><topic>Liver - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Phillips, John O.</creatorcontrib><creatorcontrib>Stohrer, Robert</creatorcontrib><creatorcontrib>Russell, Michael W.</creatorcontrib><creatorcontrib>Brown, Thomas A.</creatorcontrib><creatorcontrib>Epps, J.Miller</creatorcontrib><creatorcontrib>Kearney, John F.</creatorcontrib><creatorcontrib>Mestecky, Jiri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Phillips, John O.</au><au>Stohrer, Robert</au><au>Russell, Michael W.</au><au>Brown, Thomas A.</au><au>Epps, J.Miller</au><au>Kearney, John F.</au><au>Mestecky, Jiri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the hepatobiliary transport of IgA with monoclonal anti-idiotype and anti-allotype antibodies</atitle><jtitle>Molecular immunology</jtitle><addtitle>Mol Immunol</addtitle><date>1986-03</date><risdate>1986</risdate><volume>23</volume><issue>3</issue><spage>339</spage><epage>346</epage><pages>339-346</pages><issn>0161-5890</issn><eissn>1872-9142</eissn><abstract>The processing and fate of mixed immune complexes is influenced by the antibody isotypes present. The hepatobiliary transport of mixed immune complexes containing the mouse IgA myeloma protein J558 and corresponding monoclonal IgG or IgM anti-J558 idiotype or monoclonal IgG anti-mouse IgA allotype antibodies has been studied. The anti-idiotype or anti-allotype antibodies were radiolabeled and injected into mice with or without mouse polymeric IgA (J558). IgG anti-idiotype antibodies to J558 IgA were selectively transported into bile by J558 IgA. This process occurred with a radiolabeled Fab preparation of the IgG anti-idiotype and was inhibitable with IgA of an irrelevant antigenic specificity. Thus, polymeric IgA influenced the fate of IgA-IgG idiotype-anti-idiotype serum immune complexes. A monoclonal anti-idiotype antibody of the IgM isotype (D8-3) was not selectively transported into bile by itself or as an IgA-IgM complex. A monoclonal IgG antibody (CB5-6) to a mouse allotype determinant in the Fc portion of IgA was not selectively transported into bile. This anti-allotype monoclonal antibody inhibited the hepatobiliary transport of
125I-polymeric J558 IgA and therefore appeared to directly or indirectly block the site in the Fc region of IgA recognized by the hepatic receptor.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>3713709</pmid><doi>10.1016/0161-5890(86)90061-1</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0161-5890 |
| ispartof | Molecular immunology, 1986-03, Vol.23 (3), p.339-346 |
| issn | 0161-5890 1872-9142 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antibodies, Monoclonal - immunology Antigen-Antibody Complex - metabolism Bile - metabolism Biological Transport Immunoglobulin A - immunology Immunoglobulin A - metabolism Immunoglobulin Allotypes - immunology Immunoglobulin Fab Fragments - immunology Immunoglobulin Idiotypes - immunology Immunoglobulin M - immunology Liver - metabolism Mice Mice, Inbred Strains |
| title | Analysis of the hepatobiliary transport of IgA with monoclonal anti-idiotype and anti-allotype antibodies |
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