Pharmacokinetics and disposition of a new anticancer antibiotic (2''R)-4'-O-tetrahydropyranyladriamycin in rats. Distribution and excretion after a single administration

Blood levels, tissue distribution and excretion of (2''R)-4'-O-tetrahydropyranyladriamycin (THP) were studied in rats received 14C-THP or unlabeled THP at a dose of 5 mg/kg, respectively. The THP disappeared rapidly from the blood and transferred to tissues immediately after an admini...

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Veröffentlicht in:	Japanese journal of antibiotics 1986-02, Vol.39 (2), p.612-628
Hauptverfasser:	Tone, H, Iguchi, H, Fujigaki, M, Nishio, M, Esumi, Y, Takaichi, M, Tsutsumi, S, Yokoshima, T
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - metabolism Autoradiography Bile - metabolism Doxorubicin - administration & dosage Doxorubicin - analogs & derivatives Doxorubicin - metabolism Female Fetus - metabolism Injections, Intravenous Kinetics Male Maternal-Fetal Exchange Milk - metabolism Pregnancy Protein Binding Rats Rats, Inbred Strains Tissue Distribution
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