Involvement of the dorsal root ganglion in acute experimental allergic encephalomyelitis in the Lewis rat: A histological and electrophysiological study
Histological and electrophysiological studies were performed in Lewis rats with acute experimental allergic encephalomyelitis (EAE) in order to determine the extent of dorsal root ganglion (DRG) involvement. Histological studies showed inflammation and demyelination in both the central nervous syste...
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| Veröffentlicht in: | Journal of the neurological sciences 1986, Vol.72 (2), p.231-242 |
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| creator | Pender, M.P. Sears, T.A. |
| description | Histological and electrophysiological studies were performed in Lewis rats with acute experimental allergic encephalomyelitis (EAE) in order to determine the extent of dorsal root ganglion (DRG) involvement. Histological studies showed inflammation and demyelination in both the central nervous system (CNS) and peripheral nervous system (PNS). The DRG was the most affected region of the PNS and its involvement increased caudally. Nerve conduction abnormalities were demonstrated in the regions of the lumbar, sacral or coccygeal DRGs in some of the rats with EAE. However, the overall DRG involvement was much less severe, both histologically and functionally, than what we recently found in rabbits with EAE. Conduction through the lumbar dorsal root entry zone was normal. We conclude that lesions of the afferent pathway to the spinal cord do not contribute significantly to the disturbances of hindlimb motor function in Lewis rats with EAE. |
| doi_str_mv | 10.1016/0022-510X(86)90011-0 |
| format | Article |
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Histological studies showed inflammation and demyelination in both the central nervous system (CNS) and peripheral nervous system (PNS). The DRG was the most affected region of the PNS and its involvement increased caudally. Nerve conduction abnormalities were demonstrated in the regions of the lumbar, sacral or coccygeal DRGs in some of the rats with EAE. However, the overall DRG involvement was much less severe, both histologically and functionally, than what we recently found in rabbits with EAE. Conduction through the lumbar dorsal root entry zone was normal. We conclude that lesions of the afferent pathway to the spinal cord do not contribute significantly to the disturbances of hindlimb motor function in Lewis rats with EAE.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/0022-510X(86)90011-0</identifier><identifier>PMID: 3486944</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Conduction abnormalities ; Demyelination ; Dorsal root ganglion ; Encephalomyelitis, Autoimmune, Experimental - pathology ; Encephalomyelitis, Autoimmune, Experimental - physiopathology ; Experimental allergic encephalomyelitis ; Ganglia, Spinal - physiopathology ; Lewis rat ; Nerve conduction ; Nervous System - pathology ; Neural Conduction ; Neurons, Afferent - physiology ; Pathophysiology ; Rats ; Rats, Inbred Lew ; Reaction Time - physiology ; Spinal Nerve Roots - physiopathology ; Spinal Nerves - physiopathology</subject><ispartof>Journal of the neurological sciences, 1986, Vol.72 (2), p.231-242</ispartof><rights>1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0022510X86900110$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3486944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pender, M.P.</creatorcontrib><creatorcontrib>Sears, T.A.</creatorcontrib><title>Involvement of the dorsal root ganglion in acute experimental allergic encephalomyelitis in the Lewis rat: A histological and electrophysiological study</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>Histological and electrophysiological studies were performed in Lewis rats with acute experimental allergic encephalomyelitis (EAE) in order to determine the extent of dorsal root ganglion (DRG) involvement. Histological studies showed inflammation and demyelination in both the central nervous system (CNS) and peripheral nervous system (PNS). The DRG was the most affected region of the PNS and its involvement increased caudally. Nerve conduction abnormalities were demonstrated in the regions of the lumbar, sacral or coccygeal DRGs in some of the rats with EAE. However, the overall DRG involvement was much less severe, both histologically and functionally, than what we recently found in rabbits with EAE. Conduction through the lumbar dorsal root entry zone was normal. We conclude that lesions of the afferent pathway to the spinal cord do not contribute significantly to the disturbances of hindlimb motor function in Lewis rats with EAE.</description><subject>Animals</subject><subject>Conduction abnormalities</subject><subject>Demyelination</subject><subject>Dorsal root ganglion</subject><subject>Encephalomyelitis, Autoimmune, Experimental - pathology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - physiopathology</subject><subject>Experimental allergic encephalomyelitis</subject><subject>Ganglia, Spinal - physiopathology</subject><subject>Lewis rat</subject><subject>Nerve conduction</subject><subject>Nervous System - pathology</subject><subject>Neural Conduction</subject><subject>Neurons, Afferent - physiology</subject><subject>Pathophysiology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Reaction Time - physiology</subject><subject>Spinal Nerve Roots - physiopathology</subject><subject>Spinal Nerves - physiopathology</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks2KFDEUhYMoYzv6BgpZiS5Kk8pPJS4GhsGfgQY3Cu5CKnWrO5KulEmqtd_Ex7XiNLPVVbic7x7IOReh55S8oYTKt4S0bSMo-fZKydeaEEob8gBtqOpUI5RiD9HmHnmMnuT8nRAildIX6IJxJTXnG_T7djrGcIQDTAXHEZc94CGmbANOMRa8s9Mu-DhhP2HrlgIYfs2QfOVXxoYAaecdhsnBvLchHk4QfPG5LlSzLfxch2TLO3yN9z6XGOK6UHenAUMAV1Kc96fs74VcluH0FD0abcjw7Pxeoq8f3n-5-dRsP3-8vbneNsBaVpqBKqFh5EIxKXqrGWUceOfEaKV1vWt7JkfGR9At184K6Dj0yhE7uBUVnF2il3e-c4o_FsjFHHx2EIKdIC7ZdFJJqqn8J0g555po_j8g7bSoji_O4NIfYDDzGqtNJ3MuZ9Wv7nRY_3_0kEx2vgY9-LTGZoboDSWmHoOpTZvatFHS_D0GQ9gffYypng</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Pender, M.P.</creator><creator>Sears, T.A.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Involvement of the dorsal root ganglion in acute experimental allergic encephalomyelitis in the Lewis rat: A histological and electrophysiological study</title><author>Pender, M.P. ; Sears, T.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e323t-d1859ef458365ba93134e47c5fa6acbc2b36f34fe9249ca5e74eb8c0adc313543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Conduction abnormalities</topic><topic>Demyelination</topic><topic>Dorsal root ganglion</topic><topic>Encephalomyelitis, Autoimmune, Experimental - pathology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - physiopathology</topic><topic>Experimental allergic encephalomyelitis</topic><topic>Ganglia, Spinal - physiopathology</topic><topic>Lewis rat</topic><topic>Nerve conduction</topic><topic>Nervous System - pathology</topic><topic>Neural Conduction</topic><topic>Neurons, Afferent - physiology</topic><topic>Pathophysiology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Reaction Time - physiology</topic><topic>Spinal Nerve Roots - physiopathology</topic><topic>Spinal Nerves - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pender, M.P.</creatorcontrib><creatorcontrib>Sears, T.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pender, M.P.</au><au>Sears, T.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of the dorsal root ganglion in acute experimental allergic encephalomyelitis in the Lewis rat: A histological and electrophysiological study</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>1986</date><risdate>1986</risdate><volume>72</volume><issue>2</issue><spage>231</spage><epage>242</epage><pages>231-242</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><abstract>Histological and electrophysiological studies were performed in Lewis rats with acute experimental allergic encephalomyelitis (EAE) in order to determine the extent of dorsal root ganglion (DRG) involvement. Histological studies showed inflammation and demyelination in both the central nervous system (CNS) and peripheral nervous system (PNS). The DRG was the most affected region of the PNS and its involvement increased caudally. Nerve conduction abnormalities were demonstrated in the regions of the lumbar, sacral or coccygeal DRGs in some of the rats with EAE. However, the overall DRG involvement was much less severe, both histologically and functionally, than what we recently found in rabbits with EAE. Conduction through the lumbar dorsal root entry zone was normal. We conclude that lesions of the afferent pathway to the spinal cord do not contribute significantly to the disturbances of hindlimb motor function in Lewis rats with EAE.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>3486944</pmid><doi>10.1016/0022-510X(86)90011-0</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of the neurological sciences, 1986, Vol.72 (2), p.231-242 |
| issn | 0022-510X 1878-5883 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Conduction abnormalities Demyelination Dorsal root ganglion Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - physiopathology Experimental allergic encephalomyelitis Ganglia, Spinal - physiopathology Lewis rat Nerve conduction Nervous System - pathology Neural Conduction Neurons, Afferent - physiology Pathophysiology Rats Rats, Inbred Lew Reaction Time - physiology Spinal Nerve Roots - physiopathology Spinal Nerves - physiopathology |
| title | Involvement of the dorsal root ganglion in acute experimental allergic encephalomyelitis in the Lewis rat: A histological and electrophysiological study |
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