Autocrine Inhibition of the Epidermal Growth Factor Receptor by Intracellular Expression of a Single-Chain Antibody

A gene encoding a single-chain antibody which specifically binds the human epidermal growth factor (EGF) receptor has been constructed and expressed intracellularly. The single-chain antibody is derived from monoclonal antibody 225 which competes with EGF for binding to the extracellular domain of t...

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Veröffentlicht in:	Biochemical and biophysical research communications 1994-10, Vol.204 (2), p.666-672
Hauptverfasser:	Beerli, R.R., Wels, W., Hynes, N.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Amino Acid Sequence Animals Cell Division - immunology Cell Line, Transformed Humans Immunoglobulin Fragments - immunology Mice Molecular Sequence Data Receptor, Epidermal Growth Factor - antagonists & inhibitors
Online-Zugang:	Volltext
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