Histologic Aspects of Concomitant Resistance Induced by Nonimmunogenic Murine Tumors
Concomitant resistance to a second tumor implant was induced in both conventional and nude BALB/c mice by two non immunogenic syngeneic tumors of spontaneous origin, an epidermoid carcinoma and a lymphoid leukemia. In the secondary tumor, which was significantly inhibited by concomitant resistance,...
Gespeichert in:
| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1986-06, Vol.76 (6), p.1163-1175 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1175 |
|---|---|
| container_issue | 6 |
| container_start_page | 1163 |
| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 76 |
| creator | Meiss, Roberto P. Bonfil, R. Daniel Ruggiero, Raul A. Pasqualini, Christiane Dosne |
| description | Concomitant resistance to a second tumor implant was induced in both conventional and nude BALB/c mice by two non immunogenic syngeneic tumors of spontaneous origin, an epidermoid carcinoma and a lymphoid leukemia. In the secondary tumor, which was significantly inhibited by concomitant resistance, histologic examination revealed the presence of well-preserved tumor cells without any sign of necrosis and without any host cell infiltration, contrasting with classical immunologic rejection. Tumor cell proliferation as evaluated by the number of mitoses per high-power field was significantly inhibited in the secondary tumor as compared with the corresponding controls. No effect of concomitant resistance could be detected on primary tumor growth. |
| doi_str_mv | 10.1093/jnci/76.6.1163 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_76860313</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76860313</sourcerecordid><originalsourceid>FETCH-LOGICAL-i273t-99594b981d549f841fed58b87d2f96a83517f723fa612346396f8c4389aa48163</originalsourceid><addsrcrecordid>eNo9kEtLAzEURoMotT627oRZiLupeT-WUtQKPqBUKm6GNJOU1JmkTmbA_nsDLd7NXZxzL3wfAFcIThBU5G4TjL8TfMInCHFyBMaIclhiBNkxGEOIRSmloKfgLKUNzKMwHYERoUwqhsdgMfOpj01ce1Pcp601fSqiK6YxmNj6Xoe-mNuUHR2MLZ5DPRhbF6td8RaDb9shxLUN-fZ16HywxWJoY5cuwInTTbKXh30OPh4fFtNZ-fL-9Dy9fyk9FqQvlWKKrpRENaPKSYqcrZlcSVFjp7iWhCHhBCZOc4QJ5URxJw0lUmlNZU57Dm73f7dd_Bls6qvWJ2ObRgcbh1QJLjkkiGTx-iAOq9bW1bbzre521aGGzG8OXCejG9fltD79a0IyhYXKWrnXch_29x_r7rvigghWzT6_qjl7W8olhdWc_AGB5Hqb</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76860313</pqid></control><display><type>article</type><title>Histologic Aspects of Concomitant Resistance Induced by Nonimmunogenic Murine Tumors</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><creator>Meiss, Roberto P. ; Bonfil, R. Daniel ; Ruggiero, Raul A. ; Pasqualini, Christiane Dosne</creator><creatorcontrib>Meiss, Roberto P. ; Bonfil, R. Daniel ; Ruggiero, Raul A. ; Pasqualini, Christiane Dosne</creatorcontrib><description>Concomitant resistance to a second tumor implant was induced in both conventional and nude BALB/c mice by two non immunogenic syngeneic tumors of spontaneous origin, an epidermoid carcinoma and a lymphoid leukemia. In the secondary tumor, which was significantly inhibited by concomitant resistance, histologic examination revealed the presence of well-preserved tumor cells without any sign of necrosis and without any host cell infiltration, contrasting with classical immunologic rejection. Tumor cell proliferation as evaluated by the number of mitoses per high-power field was significantly inhibited in the secondary tumor as compared with the corresponding controls. No effect of concomitant resistance could be detected on primary tumor growth.</description><identifier>ISSN: 0027-8874</identifier><identifier>EISSN: 1460-2105</identifier><identifier>DOI: 10.1093/jnci/76.6.1163</identifier><identifier>PMID: 3458952</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Animals ; Biological and medical sciences ; Carcinoma, Squamous Cell - pathology ; Cell Division ; Female ; Graft Rejection ; Host-tumor relations. Immunology. Biological markers ; Leukemia, Experimental - pathology ; Lymphocytes - immunology ; Male ; Medical sciences ; Mice ; Mice, Inbred AKR ; Mice, Inbred BALB C ; Mice, Nude ; Mitosis ; Neoplasm Transplantation ; Neoplasms, Experimental - immunology ; Neoplasms, Experimental - pathology ; Tumors</subject><ispartof>JNCI : Journal of the National Cancer Institute, 1986-06, Vol.76 (6), p.1163-1175</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7859279$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3458952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meiss, Roberto P.</creatorcontrib><creatorcontrib>Bonfil, R. Daniel</creatorcontrib><creatorcontrib>Ruggiero, Raul A.</creatorcontrib><creatorcontrib>Pasqualini, Christiane Dosne</creatorcontrib><title>Histologic Aspects of Concomitant Resistance Induced by Nonimmunogenic Murine Tumors</title><title>JNCI : Journal of the National Cancer Institute</title><addtitle>Journal of the National Cancer Institute</addtitle><description>Concomitant resistance to a second tumor implant was induced in both conventional and nude BALB/c mice by two non immunogenic syngeneic tumors of spontaneous origin, an epidermoid carcinoma and a lymphoid leukemia. In the secondary tumor, which was significantly inhibited by concomitant resistance, histologic examination revealed the presence of well-preserved tumor cells without any sign of necrosis and without any host cell infiltration, contrasting with classical immunologic rejection. Tumor cell proliferation as evaluated by the number of mitoses per high-power field was significantly inhibited in the secondary tumor as compared with the corresponding controls. No effect of concomitant resistance could be detected on primary tumor growth.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Division</subject><subject>Female</subject><subject>Graft Rejection</subject><subject>Host-tumor relations. Immunology. Biological markers</subject><subject>Leukemia, Experimental - pathology</subject><subject>Lymphocytes - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred AKR</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Mitosis</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - immunology</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Tumors</subject><issn>0027-8874</issn><issn>1460-2105</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEURoMotT627oRZiLupeT-WUtQKPqBUKm6GNJOU1JmkTmbA_nsDLd7NXZxzL3wfAFcIThBU5G4TjL8TfMInCHFyBMaIclhiBNkxGEOIRSmloKfgLKUNzKMwHYERoUwqhsdgMfOpj01ce1Pcp601fSqiK6YxmNj6Xoe-mNuUHR2MLZ5DPRhbF6td8RaDb9shxLUN-fZ16HywxWJoY5cuwInTTbKXh30OPh4fFtNZ-fL-9Dy9fyk9FqQvlWKKrpRENaPKSYqcrZlcSVFjp7iWhCHhBCZOc4QJ5URxJw0lUmlNZU57Dm73f7dd_Bls6qvWJ2ObRgcbh1QJLjkkiGTx-iAOq9bW1bbzre521aGGzG8OXCejG9fltD79a0IyhYXKWrnXch_29x_r7rvigghWzT6_qjl7W8olhdWc_AGB5Hqb</recordid><startdate>19860601</startdate><enddate>19860601</enddate><creator>Meiss, Roberto P.</creator><creator>Bonfil, R. Daniel</creator><creator>Ruggiero, Raul A.</creator><creator>Pasqualini, Christiane Dosne</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19860601</creationdate><title>Histologic Aspects of Concomitant Resistance Induced by Nonimmunogenic Murine Tumors</title><author>Meiss, Roberto P. ; Bonfil, R. Daniel ; Ruggiero, Raul A. ; Pasqualini, Christiane Dosne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i273t-99594b981d549f841fed58b87d2f96a83517f723fa612346396f8c4389aa48163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Division</topic><topic>Female</topic><topic>Graft Rejection</topic><topic>Host-tumor relations. Immunology. Biological markers</topic><topic>Leukemia, Experimental - pathology</topic><topic>Lymphocytes - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred AKR</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Mitosis</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - immunology</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meiss, Roberto P.</creatorcontrib><creatorcontrib>Bonfil, R. Daniel</creatorcontrib><creatorcontrib>Ruggiero, Raul A.</creatorcontrib><creatorcontrib>Pasqualini, Christiane Dosne</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>JNCI : Journal of the National Cancer Institute</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meiss, Roberto P.</au><au>Bonfil, R. Daniel</au><au>Ruggiero, Raul A.</au><au>Pasqualini, Christiane Dosne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histologic Aspects of Concomitant Resistance Induced by Nonimmunogenic Murine Tumors</atitle><jtitle>JNCI : Journal of the National Cancer Institute</jtitle><addtitle>Journal of the National Cancer Institute</addtitle><date>1986-06-01</date><risdate>1986</risdate><volume>76</volume><issue>6</issue><spage>1163</spage><epage>1175</epage><pages>1163-1175</pages><issn>0027-8874</issn><eissn>1460-2105</eissn><abstract>Concomitant resistance to a second tumor implant was induced in both conventional and nude BALB/c mice by two non immunogenic syngeneic tumors of spontaneous origin, an epidermoid carcinoma and a lymphoid leukemia. In the secondary tumor, which was significantly inhibited by concomitant resistance, histologic examination revealed the presence of well-preserved tumor cells without any sign of necrosis and without any host cell infiltration, contrasting with classical immunologic rejection. Tumor cell proliferation as evaluated by the number of mitoses per high-power field was significantly inhibited in the secondary tumor as compared with the corresponding controls. No effect of concomitant resistance could be detected on primary tumor growth.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>3458952</pmid><doi>10.1093/jnci/76.6.1163</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1986-06, Vol.76 (6), p.1163-1175 |
| issn | 0027-8874 1460-2105 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76860313 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Animals Biological and medical sciences Carcinoma, Squamous Cell - pathology Cell Division Female Graft Rejection Host-tumor relations. Immunology. Biological markers Leukemia, Experimental - pathology Lymphocytes - immunology Male Medical sciences Mice Mice, Inbred AKR Mice, Inbred BALB C Mice, Nude Mitosis Neoplasm Transplantation Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology Tumors |
| title | Histologic Aspects of Concomitant Resistance Induced by Nonimmunogenic Murine Tumors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T11%3A37%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Histologic%20Aspects%20of%20Concomitant%20Resistance%20Induced%20by%20Nonimmunogenic%20Murine%20Tumors&rft.jtitle=JNCI%20:%20Journal%20of%20the%20National%20Cancer%20Institute&rft.au=Meiss,%20Roberto%20P.&rft.date=1986-06-01&rft.volume=76&rft.issue=6&rft.spage=1163&rft.epage=1175&rft.pages=1163-1175&rft.issn=0027-8874&rft.eissn=1460-2105&rft_id=info:doi/10.1093/jnci/76.6.1163&rft_dat=%3Cproquest_pubme%3E76860313%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76860313&rft_id=info:pmid/3458952&rfr_iscdi=true |