Effect of n-Alkane Kinetics in Rats on Potency Estimations and the Meyer-Overton Hypothesis

Neither lipophilicity nor vapor pressure of larger n-alkanes appear to correlate with their anesthetizing partial pressures in inspired gas. Such results suggest that the Meyer-Overton hypothesis and Fergusonʼs rule may not apply to these compounds. An alternative explanation might be that a large d...

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