Conformational changes in the cyclic undecapeptide cyclosporin induced by interaction with metal ions. An FTIR study

Infra-red spectra have been measured for the cyclic undecapeptide cyclosporin A (CsA) and three analogues CsC, CsD and CsH in acetonitrile and in the presence of 10:1 molar excess of Mg 2+, Ca 2+, Na + or Li + in the same solvent. Interaction with each of these ions is suggested by marked changes in...

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Veröffentlicht in:	International journal of biological macromolecules 1994, Vol.16 (3), p.143-148
Hauptverfasser:	Shaw, R.A., Mantsch, H.H., Chowdhry, B.Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitriles Amino Acid Sequence Calcium - pharmacology Cations - pharmacology cyclosporin Cyclosporins - chemistry Cyclosporins - drug effects infra-red spectroscopy Lithium - pharmacology Magnesium - pharmacology metal ions Molecular Sequence Data Protein Conformation Sodium - pharmacology Solutions Spectroscopy, Fourier Transform Infrared
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