RNA expression of complement regulatory proteins in human brain tumors
The expression of complement regulatory proteins (CRP) on the surface of neoplastic cells has been proposed as a mechanism by which these cells evade immune surveillance. We have examined the RNA expression of the genes that encode 5 kinds of CRP in various human brain tumors to determine whether CR...
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| Veröffentlicht in: | Cancer letters 1994-11, Vol.86 (2), p.143-149 |
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| container_title | Cancer letters |
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| creator | Shinoura, Nobusada Heffelfinger, Sue C. Miller, Maryann Shamraj, Olga I. Miura, Nam-Ho C. Larson, Jeffrey J. DeTribolet, Nicolet Warnick, Ronald E. Tew, John J. Menon, Anil G. |
| description | The expression of complement regulatory proteins (CRP) on the surface of neoplastic cells has been proposed as a mechanism by which these cells evade immune surveillance. We have examined the RNA expression of the genes that encode 5 kinds of CRP in various human brain tumors to determine whether CRP expression might play a role in the malignant progression of these tumors. The benign and atypical meningiomas, and the astrocytomas showed high expression of SP-40,40, low expression of CD59, and barely detectable expression of CD46, CD55 and
S-protein. The benign and atypical menigiomas showed significantly greater expression of SP-40,40 at the RNA level when compared to malignant meningiomas. This study describes the mRNA expression of meningiomas, astrocytomas, tumor cell lines and normal human tissues. |
| doi_str_mv | 10.1016/0304-3835(94)90072-8 |
| format | Article |
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S-protein. The benign and atypical menigiomas showed significantly greater expression of SP-40,40 at the RNA level when compared to malignant meningiomas. This study describes the mRNA expression of meningiomas, astrocytomas, tumor cell lines and normal human tissues.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(94)90072-8</identifier><identifier>PMID: 7526972</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Antigens, CD - genetics ; Astrocytoma - genetics ; Base Sequence ; Biological and medical sciences ; Brain Neoplasms - genetics ; Brain tumor ; CD55 Antigens ; CD59 ; CD59 Antigens ; Clusterin ; Complement Inactivator Proteins - genetics ; Complement regulatory protein ; Glycoproteins ; Humans ; Medical sciences ; Membrane Cofactor Protein ; Membrane Glycoproteins - genetics ; Meningioma - genetics ; Molecular Chaperones ; Molecular Sequence Data ; Neurology ; RNA - analysis ; SP40,40 ; Tumor Cells, Cultured ; Tumors of the nervous system. Phacomatoses ; Vitronectin</subject><ispartof>Cancer letters, 1994-11, Vol.86 (2), p.143-149</ispartof><rights>1994</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-268f5a65b28fbd47d2f8fae848e9ff50cdd2f7c8a66a93f045589507de4e149a3</citedby><cites>FETCH-LOGICAL-c386t-268f5a65b28fbd47d2f8fae848e9ff50cdd2f7c8a66a93f045589507de4e149a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0304383594900728$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3318940$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7526972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shinoura, Nobusada</creatorcontrib><creatorcontrib>Heffelfinger, Sue C.</creatorcontrib><creatorcontrib>Miller, Maryann</creatorcontrib><creatorcontrib>Shamraj, Olga I.</creatorcontrib><creatorcontrib>Miura, Nam-Ho C.</creatorcontrib><creatorcontrib>Larson, Jeffrey J.</creatorcontrib><creatorcontrib>DeTribolet, Nicolet</creatorcontrib><creatorcontrib>Warnick, Ronald E.</creatorcontrib><creatorcontrib>Tew, John J.</creatorcontrib><creatorcontrib>Menon, Anil G.</creatorcontrib><title>RNA expression of complement regulatory proteins in human brain tumors</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>The expression of complement regulatory proteins (CRP) on the surface of neoplastic cells has been proposed as a mechanism by which these cells evade immune surveillance. We have examined the RNA expression of the genes that encode 5 kinds of CRP in various human brain tumors to determine whether CRP expression might play a role in the malignant progression of these tumors. The benign and atypical meningiomas, and the astrocytomas showed high expression of SP-40,40, low expression of CD59, and barely detectable expression of CD46, CD55 and
S-protein. The benign and atypical menigiomas showed significantly greater expression of SP-40,40 at the RNA level when compared to malignant meningiomas. This study describes the mRNA expression of meningiomas, astrocytomas, tumor cell lines and normal human tissues.</description><subject>Antigens, CD - genetics</subject><subject>Astrocytoma - genetics</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain tumor</subject><subject>CD55 Antigens</subject><subject>CD59</subject><subject>CD59 Antigens</subject><subject>Clusterin</subject><subject>Complement Inactivator Proteins - genetics</subject><subject>Complement regulatory protein</subject><subject>Glycoproteins</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Membrane Cofactor Protein</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Meningioma - genetics</subject><subject>Molecular Chaperones</subject><subject>Molecular Sequence Data</subject><subject>Neurology</subject><subject>RNA - analysis</subject><subject>SP40,40</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Vitronectin</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRaq3-A4UcRPQQ3ST7eRFKsSoUBdHzst3M6kqSrbuJ2H9vYkuPnmaY95lheBA6zfB1hjN2gwtM0kIU9FKSK4kxz1Oxh8aZ6BsuBd5H4x1yiI5i_MQYU8LpCI04zZnk-RjNX56mCfysAsTofJN4mxhfryqooWmTAO9dpVsf1skq-BZcExPXJB9drZtkGXTft13tQzxGB1ZXEU62dYLe5nevs4d08Xz_OJsuUlMI1qY5E5ZqRpe5sMuS8DK3wmoQRIC0lmJT9hNuhGZMy8JiQqmQFPMSCGRE6mKCLjZ3-3e-Ooitql00UFW6Ad9FxZmgjBPRg2QDmuBjDGDVKrhah7XKsBr0qcGNGtwoSdSfPjWsnW3vd8sayt3S1lefn29zHY2ubNCNcXGHFUUmJME9drvBoHfx7SCoaBw0BkoXwLSq9O7_P34B9gSMBA</recordid><startdate>19941111</startdate><enddate>19941111</enddate><creator>Shinoura, Nobusada</creator><creator>Heffelfinger, Sue C.</creator><creator>Miller, Maryann</creator><creator>Shamraj, Olga I.</creator><creator>Miura, Nam-Ho C.</creator><creator>Larson, Jeffrey J.</creator><creator>DeTribolet, Nicolet</creator><creator>Warnick, Ronald E.</creator><creator>Tew, John J.</creator><creator>Menon, Anil G.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941111</creationdate><title>RNA expression of complement regulatory proteins in human brain tumors</title><author>Shinoura, Nobusada ; Heffelfinger, Sue C. ; Miller, Maryann ; Shamraj, Olga I. ; Miura, Nam-Ho C. ; Larson, Jeffrey J. ; DeTribolet, Nicolet ; Warnick, Ronald E. ; Tew, John J. ; Menon, Anil G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-268f5a65b28fbd47d2f8fae848e9ff50cdd2f7c8a66a93f045589507de4e149a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Antigens, CD - genetics</topic><topic>Astrocytoma - genetics</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain tumor</topic><topic>CD55 Antigens</topic><topic>CD59</topic><topic>CD59 Antigens</topic><topic>Clusterin</topic><topic>Complement Inactivator Proteins - genetics</topic><topic>Complement regulatory protein</topic><topic>Glycoproteins</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Membrane Cofactor Protein</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Meningioma - genetics</topic><topic>Molecular Chaperones</topic><topic>Molecular Sequence Data</topic><topic>Neurology</topic><topic>RNA - analysis</topic><topic>SP40,40</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Vitronectin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shinoura, Nobusada</creatorcontrib><creatorcontrib>Heffelfinger, Sue C.</creatorcontrib><creatorcontrib>Miller, Maryann</creatorcontrib><creatorcontrib>Shamraj, Olga I.</creatorcontrib><creatorcontrib>Miura, Nam-Ho C.</creatorcontrib><creatorcontrib>Larson, Jeffrey J.</creatorcontrib><creatorcontrib>DeTribolet, Nicolet</creatorcontrib><creatorcontrib>Warnick, Ronald E.</creatorcontrib><creatorcontrib>Tew, John J.</creatorcontrib><creatorcontrib>Menon, Anil G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shinoura, Nobusada</au><au>Heffelfinger, Sue C.</au><au>Miller, Maryann</au><au>Shamraj, Olga I.</au><au>Miura, Nam-Ho C.</au><au>Larson, Jeffrey J.</au><au>DeTribolet, Nicolet</au><au>Warnick, Ronald E.</au><au>Tew, John J.</au><au>Menon, Anil G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RNA expression of complement regulatory proteins in human brain tumors</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1994-11-11</date><risdate>1994</risdate><volume>86</volume><issue>2</issue><spage>143</spage><epage>149</epage><pages>143-149</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>The expression of complement regulatory proteins (CRP) on the surface of neoplastic cells has been proposed as a mechanism by which these cells evade immune surveillance. We have examined the RNA expression of the genes that encode 5 kinds of CRP in various human brain tumors to determine whether CRP expression might play a role in the malignant progression of these tumors. The benign and atypical meningiomas, and the astrocytomas showed high expression of SP-40,40, low expression of CD59, and barely detectable expression of CD46, CD55 and
S-protein. The benign and atypical menigiomas showed significantly greater expression of SP-40,40 at the RNA level when compared to malignant meningiomas. This study describes the mRNA expression of meningiomas, astrocytomas, tumor cell lines and normal human tissues.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>7526972</pmid><doi>10.1016/0304-3835(94)90072-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cancer letters, 1994-11, Vol.86 (2), p.143-149 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antigens, CD - genetics Astrocytoma - genetics Base Sequence Biological and medical sciences Brain Neoplasms - genetics Brain tumor CD55 Antigens CD59 CD59 Antigens Clusterin Complement Inactivator Proteins - genetics Complement regulatory protein Glycoproteins Humans Medical sciences Membrane Cofactor Protein Membrane Glycoproteins - genetics Meningioma - genetics Molecular Chaperones Molecular Sequence Data Neurology RNA - analysis SP40,40 Tumor Cells, Cultured Tumors of the nervous system. Phacomatoses Vitronectin |
| title | RNA expression of complement regulatory proteins in human brain tumors |
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