Activated terminal complement in cerebrospinal fluid in Guillain-Barre syndrome and multiple sclerosis
A quantitative enzyme-linked immunosorbent assay was used to measure the concentration of fluid-phase complement C5b-9 complexes (SC5b-9) in the cerebrospinal fluid (CSF) of 14 patients with acute monophasic Guillain-Barré Syndrome (GBS), 21 patients with multiple sclerosis (MS), and 11 patients wit...
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| Veröffentlicht in: | The Journal of immunology (1950) 1986-06, Vol.136 (12), p.4456-4459 |
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| container_end_page | 4459 |
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| container_issue | 12 |
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| container_title | The Journal of immunology (1950) |
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| creator | Sanders, ME Koski, CL Robbins, D Shin, ML Frank, MM Joiner, KA |
| description | A quantitative enzyme-linked immunosorbent assay was used to measure the concentration of fluid-phase complement C5b-9 complexes (SC5b-9) in the cerebrospinal fluid (CSF) of 14 patients with acute monophasic Guillain-Barré Syndrome (GBS), 21 patients with multiple sclerosis (MS), and 11 patients with noninflammatory central nervous system (CNS) diseases. SC5b-9 complexes were detected in the CSF of 13 of 14 patients with acute GBS (mean, 3.08 micrograms/ml; range, 0 to 7.1 micrograms/ml) and 16 of 21 patients with MS (mean, 1.83 micrograms/ml; range, 0 to 7.5 micrograms/ml). In the control group of patients with noninflammatory CNS diseases, SC5b-9 was not detected in eight of 11 and was present in low concentrations in the remaining three patients (mean, 0.28 micrograms/ml; range, 0 to 1.7 micrograms/ml). The finding of SC5b-9 complexes in the CSF of patients with GBS and MS suggests that terminal complement components may participate in the tissue-damaging processes in these diseases. |
| doi_str_mv | 10.4049/jimmunol.136.12.4456 |
| format | Article |
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SC5b-9 complexes were detected in the CSF of 13 of 14 patients with acute GBS (mean, 3.08 micrograms/ml; range, 0 to 7.1 micrograms/ml) and 16 of 21 patients with MS (mean, 1.83 micrograms/ml; range, 0 to 7.5 micrograms/ml). In the control group of patients with noninflammatory CNS diseases, SC5b-9 was not detected in eight of 11 and was present in low concentrations in the remaining three patients (mean, 0.28 micrograms/ml; range, 0 to 1.7 micrograms/ml). The finding of SC5b-9 complexes in the CSF of patients with GBS and MS suggests that terminal complement components may participate in the tissue-damaging processes in these diseases.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.136.12.4456</identifier><identifier>PMID: 3711661</identifier><identifier>CODEN: JOIMA3</identifier><language>eng</language><publisher>Bethesda, MD: Am Assoc Immnol</publisher><subject>Biological and medical sciences ; Complement Activation ; Complement Membrane Attack Complex ; Complement System Proteins - cerebrospinal fluid ; Enzyme-Linked Immunosorbent Assay ; Humans ; Medical sciences ; Multiple Sclerosis - cerebrospinal fluid ; Multiple Sclerosis - immunology ; Multiple Sclerosis - physiopathology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Polyradiculoneuropathy - cerebrospinal fluid ; Polyradiculoneuropathy - immunology ; Polyradiculoneuropathy - physiopathology</subject><ispartof>The Journal of immunology (1950), 1986-06, Vol.136 (12), p.4456-4459</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-67b7b08624d7ff20bc4059131e774c69df3f46793d28b07b2712beb7c69f9a803</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8761299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3711661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sanders, ME</creatorcontrib><creatorcontrib>Koski, CL</creatorcontrib><creatorcontrib>Robbins, D</creatorcontrib><creatorcontrib>Shin, ML</creatorcontrib><creatorcontrib>Frank, MM</creatorcontrib><creatorcontrib>Joiner, KA</creatorcontrib><title>Activated terminal complement in cerebrospinal fluid in Guillain-Barre syndrome and multiple sclerosis</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>A quantitative enzyme-linked immunosorbent assay was used to measure the concentration of fluid-phase complement C5b-9 complexes (SC5b-9) in the cerebrospinal fluid (CSF) of 14 patients with acute monophasic Guillain-Barré Syndrome (GBS), 21 patients with multiple sclerosis (MS), and 11 patients with noninflammatory central nervous system (CNS) diseases. SC5b-9 complexes were detected in the CSF of 13 of 14 patients with acute GBS (mean, 3.08 micrograms/ml; range, 0 to 7.1 micrograms/ml) and 16 of 21 patients with MS (mean, 1.83 micrograms/ml; range, 0 to 7.5 micrograms/ml). In the control group of patients with noninflammatory CNS diseases, SC5b-9 was not detected in eight of 11 and was present in low concentrations in the remaining three patients (mean, 0.28 micrograms/ml; range, 0 to 1.7 micrograms/ml). The finding of SC5b-9 complexes in the CSF of patients with GBS and MS suggests that terminal complement components may participate in the tissue-damaging processes in these diseases.</description><subject>Biological and medical sciences</subject><subject>Complement Activation</subject><subject>Complement Membrane Attack Complex</subject><subject>Complement System Proteins - cerebrospinal fluid</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Multiple Sclerosis - cerebrospinal fluid</subject><subject>Multiple Sclerosis - immunology</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Polyradiculoneuropathy - cerebrospinal fluid</subject><subject>Polyradiculoneuropathy - immunology</subject><subject>Polyradiculoneuropathy - physiopathology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEFv1DAQhS1EVZbCPwApB4S4ZDt2HDs5lgoKUqVeytmynTF1ZTuLnbDqv8fLLhWnkeZ9783oEfKOwpYDHy8ffYxrmsOWdmJL2ZbzXrwgG9r30AoB4iXZADDWUinkK_K6lEcAEMD4OTnvJKVC0A1xV3bxv_WCU7Ngjj7p0Ng57gJGTEvjU2Mxo8lz2f3VXFj9dFjfrD4E7VP7WeeMTXlKU54jNjpNTVzD4mtEU2zAavXlDTlzOhR8e5oX5MfXL_fX39rbu5vv11e3reUUllZIIw0MgvFJOsfAWA79SDuKUnIrxsl1jgs5dhMbDEjDJGUGjaySG_UA3QX5eMzd5fnXimVR0ReL9dOE81qUFEPPho5XkB9BW_8rGZ3aZR91flIU1KFe9a9eVetVlKlDvdX2_pS_mojTs-nUZ9U_nHRdrA4u62R9ecYGKSgbx4p9OmIP_ufD3mdUJeoQaihV-_3-_4t_ABoIlGM</recordid><startdate>19860615</startdate><enddate>19860615</enddate><creator>Sanders, ME</creator><creator>Koski, CL</creator><creator>Robbins, D</creator><creator>Shin, ML</creator><creator>Frank, MM</creator><creator>Joiner, KA</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860615</creationdate><title>Activated terminal complement in cerebrospinal fluid in Guillain-Barre syndrome and multiple sclerosis</title><author>Sanders, ME ; Koski, CL ; Robbins, D ; Shin, ML ; Frank, MM ; Joiner, KA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-67b7b08624d7ff20bc4059131e774c69df3f46793d28b07b2712beb7c69f9a803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Biological and medical sciences</topic><topic>Complement Activation</topic><topic>Complement Membrane Attack Complex</topic><topic>Complement System Proteins - cerebrospinal fluid</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Multiple Sclerosis - cerebrospinal fluid</topic><topic>Multiple Sclerosis - immunology</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Polyradiculoneuropathy - cerebrospinal fluid</topic><topic>Polyradiculoneuropathy - immunology</topic><topic>Polyradiculoneuropathy - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanders, ME</creatorcontrib><creatorcontrib>Koski, CL</creatorcontrib><creatorcontrib>Robbins, D</creatorcontrib><creatorcontrib>Shin, ML</creatorcontrib><creatorcontrib>Frank, MM</creatorcontrib><creatorcontrib>Joiner, KA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanders, ME</au><au>Koski, CL</au><au>Robbins, D</au><au>Shin, ML</au><au>Frank, MM</au><au>Joiner, KA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activated terminal complement in cerebrospinal fluid in Guillain-Barre syndrome and multiple sclerosis</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1986-06-15</date><risdate>1986</risdate><volume>136</volume><issue>12</issue><spage>4456</spage><epage>4459</epage><pages>4456-4459</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><coden>JOIMA3</coden><abstract>A quantitative enzyme-linked immunosorbent assay was used to measure the concentration of fluid-phase complement C5b-9 complexes (SC5b-9) in the cerebrospinal fluid (CSF) of 14 patients with acute monophasic Guillain-Barré Syndrome (GBS), 21 patients with multiple sclerosis (MS), and 11 patients with noninflammatory central nervous system (CNS) diseases. SC5b-9 complexes were detected in the CSF of 13 of 14 patients with acute GBS (mean, 3.08 micrograms/ml; range, 0 to 7.1 micrograms/ml) and 16 of 21 patients with MS (mean, 1.83 micrograms/ml; range, 0 to 7.5 micrograms/ml). In the control group of patients with noninflammatory CNS diseases, SC5b-9 was not detected in eight of 11 and was present in low concentrations in the remaining three patients (mean, 0.28 micrograms/ml; range, 0 to 1.7 micrograms/ml). The finding of SC5b-9 complexes in the CSF of patients with GBS and MS suggests that terminal complement components may participate in the tissue-damaging processes in these diseases.</abstract><cop>Bethesda, MD</cop><pub>Am Assoc Immnol</pub><pmid>3711661</pmid><doi>10.4049/jimmunol.136.12.4456</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-1767 |
| ispartof | The Journal of immunology (1950), 1986-06, Vol.136 (12), p.4456-4459 |
| issn | 0022-1767 1550-6606 |
| language | eng |
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| subjects | Biological and medical sciences Complement Activation Complement Membrane Attack Complex Complement System Proteins - cerebrospinal fluid Enzyme-Linked Immunosorbent Assay Humans Medical sciences Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - immunology Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Polyradiculoneuropathy - cerebrospinal fluid Polyradiculoneuropathy - immunology Polyradiculoneuropathy - physiopathology |
| title | Activated terminal complement in cerebrospinal fluid in Guillain-Barre syndrome and multiple sclerosis |
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