Relation between Serum Albumin Concentration and Stroke Incidence and Death: The NHANES I Epidemiologic Follow-up Study
Relatively high serum albumin levels have been associated with reduced cardio vascular mortality and coronary heart disease incidence. No prospective studies have examined serum albumin and stroke mortality and incidence. Therefore, data from the First National Health and Nutrition Examination Surve...
Gespeichert in:
| Veröffentlicht in: | American journal of epidemiology 1994-11, Vol.140 (10), p.876-888 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 888 |
|---|---|
| container_issue | 10 |
| container_start_page | 876 |
| container_title | American journal of epidemiology |
| container_volume | 140 |
| creator | Gillum, Richard F. Ingram, Deborah D. Makuc, Diane M. |
| description | Relatively high serum albumin levels have been associated with reduced cardio vascular mortality and coronary heart disease incidence. No prospective studies have examined serum albumin and stroke mortality and incidence. Therefore, data from the First National Health and Nutrition Examination Survey (NHANES I) Epidemiologic Follow-up Study were examined to assess serum albumin level as a risk factor for stroke. White men aged 65–74 years with serum albumin concentrations of >4.4 g/dl had a risk of stroke incidence over a follow-up period of 9–16 years of only about two-thirds that of men with serum albumin concentrations of 4.4 g/dl were associated with a risk of stroke incidence only one-half and a risk of stroke death only one-fourth that seen at levels |
| doi_str_mv | 10.1093/oxfordjournals.aje.a117176 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76851518</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76851518</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-6492b9ce477f4f67cc0f9db083d55a41d415ed8dabd1e4912bee0671f7a689963</originalsourceid><addsrcrecordid>eNpdkdFv0zAQxi0EGmXwJyBZgHhLsZPYjvdWlW6tVA2JjgrxYjn2haVL4s5O1O2_n0dDJXg66b7ffXe6D6EPlEwpkdkX91A5b3du8J1uwlTvYKopFVTwF2hCc8ETnjL-Ek0IIWkiU56-Rm9C2BFCqWTkDJ0JKUQq2AQdvkOj-9p1uIT-ANDhDfihxbOmHNq6w3PXGeh6f2R0Z_Gm9-4O8KoztYUo_ml-Bd3fXuCbW8DXy9n1YoNXeLGPQFu7xv2uDb50TeMOybCPBoN9fIteVfF2eDfWc_TjcnEzXybrb1er-WydmFywPuG5TEtpIBeiyisujCGVtCUpMsuYzqnNKQNbWF1aCrmkaQlAuKCV0LyQkmfn6PPRd-_d_QChV20dDDSN7sANQQleMMpoEcGP_4F__6toRjhnTBbPdhdHyngXgodK7X3dav-oKFHP2ah_s1ExGzVmE4ffjyuGsgV7Gh3DiPqnUdfB6KbyOv44nLAsYzklImLJEatDDw8nWfs7xUUmmFr-_KXW2ZbR7ZbG458A9XSs2A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1306655986</pqid></control><display><type>article</type><title>Relation between Serum Albumin Concentration and Stroke Incidence and Death: The NHANES I Epidemiologic Follow-up Study</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><source>Periodicals Index Online</source><creator>Gillum, Richard F. ; Ingram, Deborah D. ; Makuc, Diane M.</creator><creatorcontrib>Gillum, Richard F. ; Ingram, Deborah D. ; Makuc, Diane M.</creatorcontrib><description>Relatively high serum albumin levels have been associated with reduced cardio vascular mortality and coronary heart disease incidence. No prospective studies have examined serum albumin and stroke mortality and incidence. Therefore, data from the First National Health and Nutrition Examination Survey (NHANES I) Epidemiologic Follow-up Study were examined to assess serum albumin level as a risk factor for stroke. White men aged 65–74 years with serum albumin concentrations of >4.4 g/dl had a risk of stroke incidence over a follow-up period of 9–16 years of only about two-thirds that of men with serum albumin concentrations of <4.2 g/dl. This effect persisted after controlling for multiple stroke risk variables (relative risk = 0.61, 95% confidence interval 0.41–0.89). A similar association with stroke death was found in white men aged 65–74 years. Serum albumin was not associated with stroke risk in white women aged 65–74 years. In blacks aged 45–74 years, serum albumin concentrations of >4.4 g/dl were associated with a risk of stroke incidence only one-half and a risk of stroke death only one-fourth that seen at levels <4.2 g/dl after controlling other risk variables. Further studies are needed to confirm these findings and to elucidate mechanisms for the effect of serum albumin on stroke incidence and death. Am J Epidemiol 1994;140:876–88.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/oxfordjournals.aje.a117176</identifier><identifier>PMID: 7977275</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Aged ; Biological and medical sciences ; blacks ; cerebral embolism and thrombosis ; cerebral hemorrhage ; cerebrovascular disorders ; Cerebrovascular Disorders - blood ; Cerebrovascular Disorders - epidemiology ; Cerebrovascular Disorders - mortality ; Epidemiologic Methods ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; Neurology ; Risk Factors ; serum albumin ; Serum Albumin - analysis ; United States - epidemiology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>American journal of epidemiology, 1994-11, Vol.140 (10), p.876-888</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-6492b9ce477f4f67cc0f9db083d55a41d415ed8dabd1e4912bee0671f7a689963</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27869,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3354107$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7977275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gillum, Richard F.</creatorcontrib><creatorcontrib>Ingram, Deborah D.</creatorcontrib><creatorcontrib>Makuc, Diane M.</creatorcontrib><title>Relation between Serum Albumin Concentration and Stroke Incidence and Death: The NHANES I Epidemiologic Follow-up Study</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Relatively high serum albumin levels have been associated with reduced cardio vascular mortality and coronary heart disease incidence. No prospective studies have examined serum albumin and stroke mortality and incidence. Therefore, data from the First National Health and Nutrition Examination Survey (NHANES I) Epidemiologic Follow-up Study were examined to assess serum albumin level as a risk factor for stroke. White men aged 65–74 years with serum albumin concentrations of >4.4 g/dl had a risk of stroke incidence over a follow-up period of 9–16 years of only about two-thirds that of men with serum albumin concentrations of <4.2 g/dl. This effect persisted after controlling for multiple stroke risk variables (relative risk = 0.61, 95% confidence interval 0.41–0.89). A similar association with stroke death was found in white men aged 65–74 years. Serum albumin was not associated with stroke risk in white women aged 65–74 years. In blacks aged 45–74 years, serum albumin concentrations of >4.4 g/dl were associated with a risk of stroke incidence only one-half and a risk of stroke death only one-fourth that seen at levels <4.2 g/dl after controlling other risk variables. Further studies are needed to confirm these findings and to elucidate mechanisms for the effect of serum albumin on stroke incidence and death. Am J Epidemiol 1994;140:876–88.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>blacks</subject><subject>cerebral embolism and thrombosis</subject><subject>cerebral hemorrhage</subject><subject>cerebrovascular disorders</subject><subject>Cerebrovascular Disorders - blood</subject><subject>Cerebrovascular Disorders - epidemiology</subject><subject>Cerebrovascular Disorders - mortality</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Risk Factors</subject><subject>serum albumin</subject><subject>Serum Albumin - analysis</subject><subject>United States - epidemiology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNpdkdFv0zAQxi0EGmXwJyBZgHhLsZPYjvdWlW6tVA2JjgrxYjn2haVL4s5O1O2_n0dDJXg66b7ffXe6D6EPlEwpkdkX91A5b3du8J1uwlTvYKopFVTwF2hCc8ETnjL-Ek0IIWkiU56-Rm9C2BFCqWTkDJ0JKUQq2AQdvkOj-9p1uIT-ANDhDfihxbOmHNq6w3PXGeh6f2R0Z_Gm9-4O8KoztYUo_ml-Bd3fXuCbW8DXy9n1YoNXeLGPQFu7xv2uDb50TeMOybCPBoN9fIteVfF2eDfWc_TjcnEzXybrb1er-WydmFywPuG5TEtpIBeiyisujCGVtCUpMsuYzqnNKQNbWF1aCrmkaQlAuKCV0LyQkmfn6PPRd-_d_QChV20dDDSN7sANQQleMMpoEcGP_4F__6toRjhnTBbPdhdHyngXgodK7X3dav-oKFHP2ah_s1ExGzVmE4ffjyuGsgV7Gh3DiPqnUdfB6KbyOv44nLAsYzklImLJEatDDw8nWfs7xUUmmFr-_KXW2ZbR7ZbG458A9XSs2A</recordid><startdate>19941115</startdate><enddate>19941115</enddate><creator>Gillum, Richard F.</creator><creator>Ingram, Deborah D.</creator><creator>Makuc, Diane M.</creator><general>Oxford University Press</general><general>School of Hygiene and Public Health of the Johns Hopkins University</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HVZBN</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7X8</scope></search><sort><creationdate>19941115</creationdate><title>Relation between Serum Albumin Concentration and Stroke Incidence and Death: The NHANES I Epidemiologic Follow-up Study</title><author>Gillum, Richard F. ; Ingram, Deborah D. ; Makuc, Diane M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-6492b9ce477f4f67cc0f9db083d55a41d415ed8dabd1e4912bee0671f7a689963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>blacks</topic><topic>cerebral embolism and thrombosis</topic><topic>cerebral hemorrhage</topic><topic>cerebrovascular disorders</topic><topic>Cerebrovascular Disorders - blood</topic><topic>Cerebrovascular Disorders - epidemiology</topic><topic>Cerebrovascular Disorders - mortality</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Risk Factors</topic><topic>serum albumin</topic><topic>Serum Albumin - analysis</topic><topic>United States - epidemiology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gillum, Richard F.</creatorcontrib><creatorcontrib>Ingram, Deborah D.</creatorcontrib><creatorcontrib>Makuc, Diane M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 24</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - West</collection><collection>Primary Sources Access (Plan D) - International</collection><collection>Primary Sources Access & Build (Plan A) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Midwest</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Northeast</collection><collection>Primary Sources Access (Plan D) - Southeast</collection><collection>Primary Sources Access (Plan D) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Southeast</collection><collection>Primary Sources Access (Plan D) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - UK / I</collection><collection>Primary Sources Access (Plan D) - Canada</collection><collection>Primary Sources Access (Plan D) - EMEALA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - North Central</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - International</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - International</collection><collection>Primary Sources Access (Plan D) - West</collection><collection>Periodicals Index Online Segments 1-50</collection><collection>Primary Sources Access (Plan D) - APAC</collection><collection>Primary Sources Access (Plan D) - Midwest</collection><collection>Primary Sources Access (Plan D) - MEA</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - Canada</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - EMEALA</collection><collection>Primary Sources Access & Build (Plan A) - APAC</collection><collection>Primary Sources Access & Build (Plan A) - Canada</collection><collection>Primary Sources Access & Build (Plan A) - West</collection><collection>Primary Sources Access & Build (Plan A) - EMEALA</collection><collection>Primary Sources Access (Plan D) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - Midwest</collection><collection>Primary Sources Access & Build (Plan A) - North Central</collection><collection>Primary Sources Access & Build (Plan A) - Northeast</collection><collection>Primary Sources Access & Build (Plan A) - South Central</collection><collection>Primary Sources Access & Build (Plan A) - Southeast</collection><collection>Primary Sources Access (Plan D) - UK / I</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - APAC</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - MEA</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gillum, Richard F.</au><au>Ingram, Deborah D.</au><au>Makuc, Diane M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation between Serum Albumin Concentration and Stroke Incidence and Death: The NHANES I Epidemiologic Follow-up Study</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>1994-11-15</date><risdate>1994</risdate><volume>140</volume><issue>10</issue><spage>876</spage><epage>888</epage><pages>876-888</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Relatively high serum albumin levels have been associated with reduced cardio vascular mortality and coronary heart disease incidence. No prospective studies have examined serum albumin and stroke mortality and incidence. Therefore, data from the First National Health and Nutrition Examination Survey (NHANES I) Epidemiologic Follow-up Study were examined to assess serum albumin level as a risk factor for stroke. White men aged 65–74 years with serum albumin concentrations of >4.4 g/dl had a risk of stroke incidence over a follow-up period of 9–16 years of only about two-thirds that of men with serum albumin concentrations of <4.2 g/dl. This effect persisted after controlling for multiple stroke risk variables (relative risk = 0.61, 95% confidence interval 0.41–0.89). A similar association with stroke death was found in white men aged 65–74 years. Serum albumin was not associated with stroke risk in white women aged 65–74 years. In blacks aged 45–74 years, serum albumin concentrations of >4.4 g/dl were associated with a risk of stroke incidence only one-half and a risk of stroke death only one-fourth that seen at levels <4.2 g/dl after controlling other risk variables. Further studies are needed to confirm these findings and to elucidate mechanisms for the effect of serum albumin on stroke incidence and death. Am J Epidemiol 1994;140:876–88.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>7977275</pmid><doi>10.1093/oxfordjournals.aje.a117176</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9262 |
| ispartof | American journal of epidemiology, 1994-11, Vol.140 (10), p.876-888 |
| issn | 0002-9262 1476-6256 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76851518 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy; Periodicals Index Online |
| subjects | Adult Aged Biological and medical sciences blacks cerebral embolism and thrombosis cerebral hemorrhage cerebrovascular disorders Cerebrovascular Disorders - blood Cerebrovascular Disorders - epidemiology Cerebrovascular Disorders - mortality Epidemiologic Methods Female Follow-Up Studies Humans Incidence Male Medical sciences Middle Aged Neurology Risk Factors serum albumin Serum Albumin - analysis United States - epidemiology Vascular diseases and vascular malformations of the nervous system |
| title | Relation between Serum Albumin Concentration and Stroke Incidence and Death: The NHANES I Epidemiologic Follow-up Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T12%3A52%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relation%20between%20Serum%20Albumin%20Concentration%20and%20Stroke%20Incidence%20and%20Death:%20The%20NHANES%20I%20Epidemiologic%20Follow-up%20Study&rft.jtitle=American%20journal%20of%20epidemiology&rft.au=Gillum,%20Richard%20F.&rft.date=1994-11-15&rft.volume=140&rft.issue=10&rft.spage=876&rft.epage=888&rft.pages=876-888&rft.issn=0002-9262&rft.eissn=1476-6256&rft.coden=AJEPAS&rft_id=info:doi/10.1093/oxfordjournals.aje.a117176&rft_dat=%3Cproquest_cross%3E76851518%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1306655986&rft_id=info:pmid/7977275&rfr_iscdi=true |