Effect of 1α,25-Dihydroxyvitamin D3 on the Morphologic and Biochemical Differentiation of Cultured Human Epidermal Keratinocytes Grown in Serum-Free Conditions

The effect of 1α,25-dihydroxyvitamin D3 [1α,25-(OH)2- D3] on the proliferation and morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown under defined, serum-free conditions was studied. 1α,25-(OH)2-D3 caused a dose-dependent decrease in proliferation and an inc...

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Veröffentlicht in:	Journal of investigative dermatology 1986-06, Vol.86 (6), p.709-714
Hauptverfasser:	Smith, Ellen L, Walworth, Nancy C, Holick, Michael F
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcitriol - pharmacology Cell Differentiation - drug effects Cells, Cultured DNA - metabolism Enzyme Activation Epidermal Cells Fundamental and applied biological sciences. Psychology Humans Keratins - analysis Thymidine - metabolism Transglutaminases - metabolism Tritium Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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