Endothelium-dependent relaxation of human resistance arteries in pregnancy
Objective: Reduced peripheral vascular resistance is an integral component of vascular adaptation in pregnancy. The precise mediators of the reduced resistance are unknown, however, and are often assessed by indirect means. In this study we investigated endothelium-dependent relaxation directly by e...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1994-11, Vol.171 (5), p.1309-1315 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | McCarthy, Andrew L. Taylor, Paul Graves, John Raju, Shanti K. Poston, Lucilla |
| description | Objective: Reduced peripheral vascular resistance is an integral component of vascular adaptation in pregnancy. The precise mediators of the reduced resistance are unknown, however, and are often assessed by indirect means. In this study we investigated endothelium-dependent relaxation directly by examining acetylcholine-mediated relaxation in small arteries dissected from the subcutaneous fat layer undergoing biopsy at the time of gynecologic surgery and cesarean section.
Study Design: By means of a small vessel myograph we measured tension in resistance arteries of normal pregnant (n = 22) and nonpregnant (n = 10) women and assessed the contributions of vasodilatory prostanoids and endothelium-derived relaxing factor on endothelium-dependent relaxation, as elicited by acetylcholine (1 nmol/L to 10 μmol/L) after precontraction with 3 μmol/L norepinephrine.
Results: Endothelium-dependent relaxation was similar in arteries of pregnant and nonpregnant women. Sodium nitroprusside-induced relaxation was similar in arteries of pregnant and nonpregnant women.
Conclusion: This study fails to demonstrate any increase in acetylcholine-induced endothelium-dependent relaxation in small subcutaneous arteries in pregnancy. |
| doi_str_mv | 10.1016/0002-9378(94)90153-8 |
| format | Article |
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Study Design: By means of a small vessel myograph we measured tension in resistance arteries of normal pregnant (n = 22) and nonpregnant (n = 10) women and assessed the contributions of vasodilatory prostanoids and endothelium-derived relaxing factor on endothelium-dependent relaxation, as elicited by acetylcholine (1 nmol/L to 10 μmol/L) after precontraction with 3 μmol/L norepinephrine.
Results: Endothelium-dependent relaxation was similar in arteries of pregnant and nonpregnant women. Sodium nitroprusside-induced relaxation was similar in arteries of pregnant and nonpregnant women.
Conclusion: This study fails to demonstrate any increase in acetylcholine-induced endothelium-dependent relaxation in small subcutaneous arteries in pregnancy.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(94)90153-8</identifier><identifier>PMID: 7977539</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Acetylcholine - pharmacology ; Adult ; Arginine - analogs & derivatives ; Arginine - pharmacology ; Arteries - drug effects ; Arteries - physiology ; Biological and medical sciences ; endothelium ; Endothelium, Vascular - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Indomethacin - pharmacology ; Mother. Fetoplacental unit. Mammary gland. Milk ; NG-Nitroarginine Methyl Ester ; nitric oxide ; Nitric Oxide - antagonists & inhibitors ; Pregnancy ; Pregnancy - physiology ; Pregnancy. Parturition. Lactation ; prostaglandins ; Reference Values ; Vascular Resistance ; Vasoconstriction - drug effects ; Vasodilation - physiology ; Vertebrates: reproduction</subject><ispartof>American journal of obstetrics and gynecology, 1994-11, Vol.171 (5), p.1309-1315</ispartof><rights>1994 Mosby-Year Book, Inc.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-836ef3113114503ba9678bc956b580f5e6cbe8fd4ad0315534d02bc33152e66c3</citedby><cites>FETCH-LOGICAL-c386t-836ef3113114503ba9678bc956b580f5e6cbe8fd4ad0315534d02bc33152e66c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9378(94)90153-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3341972$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7977539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McCarthy, Andrew L.</creatorcontrib><creatorcontrib>Taylor, Paul</creatorcontrib><creatorcontrib>Graves, John</creatorcontrib><creatorcontrib>Raju, Shanti K.</creatorcontrib><creatorcontrib>Poston, Lucilla</creatorcontrib><title>Endothelium-dependent relaxation of human resistance arteries in pregnancy</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective: Reduced peripheral vascular resistance is an integral component of vascular adaptation in pregnancy. The precise mediators of the reduced resistance are unknown, however, and are often assessed by indirect means. In this study we investigated endothelium-dependent relaxation directly by examining acetylcholine-mediated relaxation in small arteries dissected from the subcutaneous fat layer undergoing biopsy at the time of gynecologic surgery and cesarean section.
Study Design: By means of a small vessel myograph we measured tension in resistance arteries of normal pregnant (n = 22) and nonpregnant (n = 10) women and assessed the contributions of vasodilatory prostanoids and endothelium-derived relaxing factor on endothelium-dependent relaxation, as elicited by acetylcholine (1 nmol/L to 10 μmol/L) after precontraction with 3 μmol/L norepinephrine.
Results: Endothelium-dependent relaxation was similar in arteries of pregnant and nonpregnant women. Sodium nitroprusside-induced relaxation was similar in arteries of pregnant and nonpregnant women.
Conclusion: This study fails to demonstrate any increase in acetylcholine-induced endothelium-dependent relaxation in small subcutaneous arteries in pregnancy.</description><subject>Acetylcholine - pharmacology</subject><subject>Adult</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - pharmacology</subject><subject>Arteries - drug effects</subject><subject>Arteries - physiology</subject><subject>Biological and medical sciences</subject><subject>endothelium</subject><subject>Endothelium, Vascular - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Indomethacin - pharmacology</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>NG-Nitroarginine Methyl Ester</subject><subject>nitric oxide</subject><subject>Nitric Oxide - antagonists & inhibitors</subject><subject>Pregnancy</subject><subject>Pregnancy - physiology</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>prostaglandins</subject><subject>Reference Values</subject><subject>Vascular Resistance</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasodilation - physiology</subject><subject>Vertebrates: reproduction</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQgIMouj7-gUIPInqoJk2TJhdBZH0heNFzSJOpRtp0TVpx_72pu-xRCEwy882Q-RA6JviSYMKvMMZFLmklzmV5ITFhNBdbaEawrHIuuNhGsw2yh_Zj_JyehSx20W4lq4pROUNPc2_74QNaN3a5hQV4C37IArT6Rw-u91nfZB9jp33KRRcH7Q1kOgwQHMTM-WwR4N2n7PIQ7TS6jXC0jgfo7W7-evuQP7_cP97ePOeGCj7kgnJoKCHplAzTWkteidpIxmsmcMOAmxpEY0ttMSWM0dLiojY03Qvg3NADdLaauwj91whxUJ2LBtpWe-jHqCouGBacJLBcgSb0MQZo1CK4ToelIlhNCtUkRE1-lCzVn0IlUtvJev5Yd2A3TWtnqX66rutodNuEtLyLG4zSksiqSNj1CoPk4ttBUNE4SPasC2AGZXv3_z9-Ae_zjMc</recordid><startdate>19941101</startdate><enddate>19941101</enddate><creator>McCarthy, Andrew L.</creator><creator>Taylor, Paul</creator><creator>Graves, John</creator><creator>Raju, Shanti K.</creator><creator>Poston, Lucilla</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19941101</creationdate><title>Endothelium-dependent relaxation of human resistance arteries in pregnancy</title><author>McCarthy, Andrew L. ; Taylor, Paul ; Graves, John ; Raju, Shanti K. ; Poston, Lucilla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-836ef3113114503ba9678bc956b580f5e6cbe8fd4ad0315534d02bc33152e66c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Adult</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - pharmacology</topic><topic>Arteries - drug effects</topic><topic>Arteries - physiology</topic><topic>Biological and medical sciences</topic><topic>endothelium</topic><topic>Endothelium, Vascular - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Indomethacin - pharmacology</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>NG-Nitroarginine Methyl Ester</topic><topic>nitric oxide</topic><topic>Nitric Oxide - antagonists & inhibitors</topic><topic>Pregnancy</topic><topic>Pregnancy - physiology</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>prostaglandins</topic><topic>Reference Values</topic><topic>Vascular Resistance</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasodilation - physiology</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCarthy, Andrew L.</creatorcontrib><creatorcontrib>Taylor, Paul</creatorcontrib><creatorcontrib>Graves, John</creatorcontrib><creatorcontrib>Raju, Shanti K.</creatorcontrib><creatorcontrib>Poston, Lucilla</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCarthy, Andrew L.</au><au>Taylor, Paul</au><au>Graves, John</au><au>Raju, Shanti K.</au><au>Poston, Lucilla</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelium-dependent relaxation of human resistance arteries in pregnancy</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1994-11-01</date><risdate>1994</risdate><volume>171</volume><issue>5</issue><spage>1309</spage><epage>1315</epage><pages>1309-1315</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective: Reduced peripheral vascular resistance is an integral component of vascular adaptation in pregnancy. The precise mediators of the reduced resistance are unknown, however, and are often assessed by indirect means. In this study we investigated endothelium-dependent relaxation directly by examining acetylcholine-mediated relaxation in small arteries dissected from the subcutaneous fat layer undergoing biopsy at the time of gynecologic surgery and cesarean section.
Study Design: By means of a small vessel myograph we measured tension in resistance arteries of normal pregnant (n = 22) and nonpregnant (n = 10) women and assessed the contributions of vasodilatory prostanoids and endothelium-derived relaxing factor on endothelium-dependent relaxation, as elicited by acetylcholine (1 nmol/L to 10 μmol/L) after precontraction with 3 μmol/L norepinephrine.
Results: Endothelium-dependent relaxation was similar in arteries of pregnant and nonpregnant women. Sodium nitroprusside-induced relaxation was similar in arteries of pregnant and nonpregnant women.
Conclusion: This study fails to demonstrate any increase in acetylcholine-induced endothelium-dependent relaxation in small subcutaneous arteries in pregnancy.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>7977539</pmid><doi>10.1016/0002-9378(94)90153-8</doi><tpages>7</tpages></addata></record> |
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| subjects | Acetylcholine - pharmacology Adult Arginine - analogs & derivatives Arginine - pharmacology Arteries - drug effects Arteries - physiology Biological and medical sciences endothelium Endothelium, Vascular - physiology Female Fundamental and applied biological sciences. Psychology Humans Indomethacin - pharmacology Mother. Fetoplacental unit. Mammary gland. Milk NG-Nitroarginine Methyl Ester nitric oxide Nitric Oxide - antagonists & inhibitors Pregnancy Pregnancy - physiology Pregnancy. Parturition. Lactation prostaglandins Reference Values Vascular Resistance Vasoconstriction - drug effects Vasodilation - physiology Vertebrates: reproduction |
| title | Endothelium-dependent relaxation of human resistance arteries in pregnancy |
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