Effect of Lipid Extracts of Fecal Water from Colorectal Tumor Patients on DNA Synthesis in Swiss 3T3 Cells
Geltner-Allinger U, Branting C, Rafter JJ. Effect of lipid extracts of fecal water from colorectal tumor patients on DNA synthesis in Swiss 3T3 cells. Scand J Gastroenterol 1994;29:736-739. Background: Alterations in the proliferative activity of the colonic epithelium play a central role in the dev...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1994, Vol.29 (8), p.736-739 |
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| creator | Geltner-Allinger, U. Branting, C. Rafter, J. J. |
| description | Geltner-Allinger U, Branting C, Rafter JJ. Effect of lipid extracts of fecal water from colorectal tumor patients on DNA synthesis in Swiss 3T3 cells. Scand J Gastroenterol 1994;29:736-739.
Background: Alterations in the proliferative activity of the colonic epithelium play a central role in the development of human colon cancer. It has been suggested that crypt cell hyperproliferation may partly be due to cell regeneration after exposure to cytotoxic surfactants in fecal water. Methods: The present study determined whether lipid extracts of fecal water from colorectal tumor patients had the capacity to influence DNA synthesis in growing and quiescent Swiss 3T3 cells, at concentrations at which no cytotoxicity was evident. Results: Four of five such extracts significantly increased DNA synthesis in growing cells but were without effect on quiescent cells. Comparison of the effects of the lipid extracts on the cells with that of bile acids, compounds that have received much attention as potential regulators of proliferation, indicated that the effect of the lipid extracts could not solely be attributed to bile acids. Conclusions: Lipid components of fecal water may also influence cell proliferation through mechanisms other than cytotoxicity. |
| doi_str_mv | 10.3109/00365529409092502 |
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Background: Alterations in the proliferative activity of the colonic epithelium play a central role in the development of human colon cancer. It has been suggested that crypt cell hyperproliferation may partly be due to cell regeneration after exposure to cytotoxic surfactants in fecal water. Methods: The present study determined whether lipid extracts of fecal water from colorectal tumor patients had the capacity to influence DNA synthesis in growing and quiescent Swiss 3T3 cells, at concentrations at which no cytotoxicity was evident. Results: Four of five such extracts significantly increased DNA synthesis in growing cells but were without effect on quiescent cells. Comparison of the effects of the lipid extracts on the cells with that of bile acids, compounds that have received much attention as potential regulators of proliferation, indicated that the effect of the lipid extracts could not solely be attributed to bile acids. Conclusions: Lipid components of fecal water may also influence cell proliferation through mechanisms other than cytotoxicity.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.3109/00365529409092502</identifier><identifier>PMID: 7973434</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>3T3 Cells - cytology ; Adenocarcinoma - chemistry ; Adenoma - chemistry ; Aged ; Animals ; Bile acids ; Bile Acids and Salts - pharmacology ; Biological and medical sciences ; Body Water - chemistry ; Cell Division - drug effects ; colon cancer ; Colorectal Neoplasms - chemistry ; DNA - biosynthesis ; DNA synthesis ; Feces - chemistry ; Female ; Fibroblasts ; Gastroenterology. Liver. Pancreas. Abdomen ; human feces ; Humans ; lipid extracts ; Lipids - pharmacology ; Male ; Medical sciences ; Mice ; Middle Aged ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Scandinavian journal of gastroenterology, 1994, Vol.29 (8), p.736-739</ispartof><rights>1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1994</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-69c40cccfd7613f65f6c01051c9c0c2a03b1e2e7efb7e0556edc08affb1c4b03</citedby><cites>FETCH-LOGICAL-c430t-69c40cccfd7613f65f6c01051c9c0c2a03b1e2e7efb7e0556edc08affb1c4b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365529409092502$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365529409092502$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4228972$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7973434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geltner-Allinger, U.</creatorcontrib><creatorcontrib>Branting, C.</creatorcontrib><creatorcontrib>Rafter, J. J.</creatorcontrib><title>Effect of Lipid Extracts of Fecal Water from Colorectal Tumor Patients on DNA Synthesis in Swiss 3T3 Cells</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Geltner-Allinger U, Branting C, Rafter JJ. Effect of lipid extracts of fecal water from colorectal tumor patients on DNA synthesis in Swiss 3T3 cells. Scand J Gastroenterol 1994;29:736-739.
Background: Alterations in the proliferative activity of the colonic epithelium play a central role in the development of human colon cancer. It has been suggested that crypt cell hyperproliferation may partly be due to cell regeneration after exposure to cytotoxic surfactants in fecal water. Methods: The present study determined whether lipid extracts of fecal water from colorectal tumor patients had the capacity to influence DNA synthesis in growing and quiescent Swiss 3T3 cells, at concentrations at which no cytotoxicity was evident. Results: Four of five such extracts significantly increased DNA synthesis in growing cells but were without effect on quiescent cells. Comparison of the effects of the lipid extracts on the cells with that of bile acids, compounds that have received much attention as potential regulators of proliferation, indicated that the effect of the lipid extracts could not solely be attributed to bile acids. Conclusions: Lipid components of fecal water may also influence cell proliferation through mechanisms other than cytotoxicity.</description><subject>3T3 Cells - cytology</subject><subject>Adenocarcinoma - chemistry</subject><subject>Adenoma - chemistry</subject><subject>Aged</subject><subject>Animals</subject><subject>Bile acids</subject><subject>Bile Acids and Salts - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Body Water - chemistry</subject><subject>Cell Division - drug effects</subject><subject>colon cancer</subject><subject>Colorectal Neoplasms - chemistry</subject><subject>DNA - biosynthesis</subject><subject>DNA synthesis</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Fibroblasts</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>human feces</subject><subject>Humans</subject><subject>lipid extracts</subject><subject>Lipids - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Middle Aged</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFr3DAQhUVpSTdpf0APBR1Kbm5GlmzZtJew3bSBpQlkoUcjyyNWi21tJZl0_31kdhsohZwG5n3vMfMI-cDgM2dQXwHwsijyWkANdV5A_oosWBqZlFC9JotZzxLA3pLzEHYAUEhRn5EzWUsuuFiQ3coY1JE6Q9d2bzu6-hO90jHMmxvUqqe_VERPjXcDXbre-YSn7WYanKf3KlocZ3qk335e04fDGLcYbKB2pA-PNgTKN5wuse_DO_LGqD7g-9O8IJub1Wb5I1vffb9dXq8zLTjErKy1AK216WTJuCkLU2pgUDBda9C5At4yzFGiaSVCUZTYaaiUMS3TogV-QS6PsXvvfk8YYjPYoNMBakQ3hUaWlSgr4AlkR1B7F4JH0-y9HZQ_NAyaud7mv3qT5-MpfGoH7J4dpz6T_umkq5C6M16N2oZnTOR5Vcs55usRs6NxflCPzvddE9Uh1fvXw1-64ss_9i2qPm618tjs3OTH1O4LPzwBI_2muw</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Geltner-Allinger, U.</creator><creator>Branting, C.</creator><creator>Rafter, J. J.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1994</creationdate><title>Effect of Lipid Extracts of Fecal Water from Colorectal Tumor Patients on DNA Synthesis in Swiss 3T3 Cells</title><author>Geltner-Allinger, U. ; Branting, C. ; Rafter, J. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-69c40cccfd7613f65f6c01051c9c0c2a03b1e2e7efb7e0556edc08affb1c4b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>3T3 Cells - cytology</topic><topic>Adenocarcinoma - chemistry</topic><topic>Adenoma - chemistry</topic><topic>Aged</topic><topic>Animals</topic><topic>Bile acids</topic><topic>Bile Acids and Salts - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Body Water - chemistry</topic><topic>Cell Division - drug effects</topic><topic>colon cancer</topic><topic>Colorectal Neoplasms - chemistry</topic><topic>DNA - biosynthesis</topic><topic>DNA synthesis</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Fibroblasts</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>human feces</topic><topic>Humans</topic><topic>lipid extracts</topic><topic>Lipids - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Middle Aged</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geltner-Allinger, U.</creatorcontrib><creatorcontrib>Branting, C.</creatorcontrib><creatorcontrib>Rafter, J. J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geltner-Allinger, U.</au><au>Branting, C.</au><au>Rafter, J. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Lipid Extracts of Fecal Water from Colorectal Tumor Patients on DNA Synthesis in Swiss 3T3 Cells</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1994</date><risdate>1994</risdate><volume>29</volume><issue>8</issue><spage>736</spage><epage>739</epage><pages>736-739</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Geltner-Allinger U, Branting C, Rafter JJ. Effect of lipid extracts of fecal water from colorectal tumor patients on DNA synthesis in Swiss 3T3 cells. Scand J Gastroenterol 1994;29:736-739.
Background: Alterations in the proliferative activity of the colonic epithelium play a central role in the development of human colon cancer. It has been suggested that crypt cell hyperproliferation may partly be due to cell regeneration after exposure to cytotoxic surfactants in fecal water. Methods: The present study determined whether lipid extracts of fecal water from colorectal tumor patients had the capacity to influence DNA synthesis in growing and quiescent Swiss 3T3 cells, at concentrations at which no cytotoxicity was evident. Results: Four of five such extracts significantly increased DNA synthesis in growing cells but were without effect on quiescent cells. Comparison of the effects of the lipid extracts on the cells with that of bile acids, compounds that have received much attention as potential regulators of proliferation, indicated that the effect of the lipid extracts could not solely be attributed to bile acids. Conclusions: Lipid components of fecal water may also influence cell proliferation through mechanisms other than cytotoxicity.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>7973434</pmid><doi>10.3109/00365529409092502</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | 3T3 Cells - cytology Adenocarcinoma - chemistry Adenoma - chemistry Aged Animals Bile acids Bile Acids and Salts - pharmacology Biological and medical sciences Body Water - chemistry Cell Division - drug effects colon cancer Colorectal Neoplasms - chemistry DNA - biosynthesis DNA synthesis Feces - chemistry Female Fibroblasts Gastroenterology. Liver. Pancreas. Abdomen human feces Humans lipid extracts Lipids - pharmacology Male Medical sciences Mice Middle Aged Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Effect of Lipid Extracts of Fecal Water from Colorectal Tumor Patients on DNA Synthesis in Swiss 3T3 Cells |
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