Neuropathology of twitcher mice: examination by histochemistry, immunohistochemistry, lectin histochemistry and fourier transform infrared microspectroscopy

The twitcher mouse is an authentic animal model of globoid cell leukodystrophy, which is a genetic disease that affects the lysosomal enzyme galactocerebroside β‐galactosidase. This enzyme deficiency causes one of its substrates, galactosylsphingosine (psychosine), to accumulate in myelin‐forming ce...

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Veröffentlicht in:	International journal of developmental neuroscience 1994-06, Vol.12 (4), p.275-288
Hauptverfasser:	Levine, Steven M., Wetzel, David L., Eilert, Arnold J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Chemistry - physiology Cerebral Cortex - metabolism Cerebral Cortex - pathology Glial Fibrillary Acidic Protein - metabolism globoid cell leukodystrophy Immunohistochemistry In Situ Hybridization Lectins Mice Mice, Neurologic Mutants myelin Nervous System Diseases - genetics Nervous System Diseases - metabolism Nervous System Diseases - pathology oligodendrocyte psychosine Psychosine - metabolism Rhombencephalon - metabolism Rhombencephalon - pathology Schiff Bases Spectroscopy, Fourier Transform Infrared Staining and Labeling
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