Herpes Simplex Virus Complement Fixing Antibody and Herpes B Virus Serum Neutralizing Antibody in Sera of Wild and Laboratory-bred Cynomolgus Monkeys

The result of the complement fixation (CF) test for the antibody to herpes simplex virus (HSV) in sera of the cynomolgus monkeys was compared with that of the neutralization test (NS) for the antibody to herpes B virus (HBV) in the same sera. Fifty-seven (74 %) of 77 wild-originated monkeys were pos...

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Veröffentlicht in:Experimental Animals 1986/01/01, Vol.35(1), pp.59-63
Hauptverfasser: SASAGAWA, Akira, SUZUKI, Makoto, NARITA, Toyoko, HONJO, Shigeo, KALTER, S.S.
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container_end_page 63
container_issue 1
container_start_page 59
container_title Experimental Animals
container_volume 35
creator SASAGAWA, Akira
SUZUKI, Makoto
NARITA, Toyoko
HONJO, Shigeo
KALTER, S.S.
description The result of the complement fixation (CF) test for the antibody to herpes simplex virus (HSV) in sera of the cynomolgus monkeys was compared with that of the neutralization test (NS) for the antibody to herpes B virus (HBV) in the same sera. Fifty-seven (74 %) of 77 wild-originated monkeys were positive for HSV-CF, while 65 (84 %) of the 77 animals were positive for HBV-SN. All of the 57 CF positive cases were also positive for HBV-SN. On the other hand, 30 (75 %) of 40 laboratory-bred monkeys had neither HSV-CF antibody nor HBV-SN antibody. Remaining 10 of the 40 laboratorybred animals were positive for HSV-CF. However, no HBV-SN antibody was detected in nine of the 10 HSV-CF positive animals. These results suggest that the HSV-CF test may be as satisfactory as the HSV-SN test as a practical measure for rough screening of HBV infection in the cynomolgus monkey in laboratories having no containment unit for handling HBV.
doi_str_mv 10.1538/expanim1978.35.1_59
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source MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese
subjects Animals
Animals, Laboratory
Antibodies, Viral - analysis
Complement Fixation Tests
Female
Herpesviridae - immunology
Herpesviridae Infections - diagnosis
Herpesviridae Infections - veterinary
Herpesvirus 1, Cercopithecine - immunology
Macaca - microbiology
Macaca fascicularis - immunology
Macaca fascicularis - microbiology
Male
Monkey Diseases - diagnosis
Neutralization Tests
Simplexvirus - immunology
title Herpes Simplex Virus Complement Fixing Antibody and Herpes B Virus Serum Neutralizing Antibody in Sera of Wild and Laboratory-bred Cynomolgus Monkeys
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