Immunosuppressive therapy and plasmapheresis in rapidly progressive glomerulonephritis associated with bacterial endocarditis
A 25-year-old male presented with new cardiac murmurs and acute renal insufficiency. Blood cultures grew Streptococcus viridans and appropriate antibiotic therapy was initiated. A renal biopsy revealed diffuse proliferative glomerulonephritis with crescents involving more than 50% of the glomeruli....
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Veröffentlicht in: | American journal of kidney diseases 1986-05, Vol.7 (5), p.428-433 |
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creator | Rovzar, M A Logan, J L Ogden, D A Graham, A R |
description | A 25-year-old male presented with new cardiac murmurs and acute renal insufficiency. Blood cultures grew Streptococcus viridans and appropriate antibiotic therapy was initiated. A renal biopsy revealed diffuse proliferative glomerulonephritis with crescents involving more than 50% of the glomeruli. Treatment with antibiotics, plasmapheresis, and steroids resulted in renal recovery that paralleled reductions in circulating immune complexes. The rationale for this therapeutic approach is discussed, as well as a review of two similar case reports. These experiences suggest a possible role for plasmapheresis and immunosuppressive drugs in patients who develop rapidly progressive glomerulonephritis as a complication of bacterial endocarditis. |
doi_str_mv | 10.1016/S0272-6386(86)80093-2 |
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Blood cultures grew Streptococcus viridans and appropriate antibiotic therapy was initiated. A renal biopsy revealed diffuse proliferative glomerulonephritis with crescents involving more than 50% of the glomeruli. Treatment with antibiotics, plasmapheresis, and steroids resulted in renal recovery that paralleled reductions in circulating immune complexes. The rationale for this therapeutic approach is discussed, as well as a review of two similar case reports. These experiences suggest a possible role for plasmapheresis and immunosuppressive drugs in patients who develop rapidly progressive glomerulonephritis as a complication of bacterial endocarditis.</description><identifier>ISSN: 0272-6386</identifier><identifier>DOI: 10.1016/S0272-6386(86)80093-2</identifier><identifier>PMID: 3706297</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Antigen-Antibody Complex - analysis ; Azathioprine - administration & dosage ; Creatinine - blood ; Drug Therapy, Combination ; Endocarditis, Bacterial - complications ; Endocarditis, Bacterial - immunology ; Glomerulonephritis - etiology ; Glomerulonephritis - pathology ; Glomerulonephritis - therapy ; Humans ; Male ; Plasmapheresis ; Prednisone - administration & dosage ; Streptococcal Infections - complications ; Time Factors</subject><ispartof>American journal of kidney diseases, 1986-05, Vol.7 (5), p.428-433</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c304t-de13aa80bc0b6ce9ca66c9e20d0f88aa627d5680a48c0517b6213a5420c8ad8f3</citedby><cites>FETCH-LOGICAL-c304t-de13aa80bc0b6ce9ca66c9e20d0f88aa627d5680a48c0517b6213a5420c8ad8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3706297$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rovzar, M A</creatorcontrib><creatorcontrib>Logan, J L</creatorcontrib><creatorcontrib>Ogden, D A</creatorcontrib><creatorcontrib>Graham, A R</creatorcontrib><title>Immunosuppressive therapy and plasmapheresis in rapidly progressive glomerulonephritis associated with bacterial endocarditis</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>A 25-year-old male presented with new cardiac murmurs and acute renal insufficiency. Blood cultures grew Streptococcus viridans and appropriate antibiotic therapy was initiated. A renal biopsy revealed diffuse proliferative glomerulonephritis with crescents involving more than 50% of the glomeruli. Treatment with antibiotics, plasmapheresis, and steroids resulted in renal recovery that paralleled reductions in circulating immune complexes. The rationale for this therapeutic approach is discussed, as well as a review of two similar case reports. These experiences suggest a possible role for plasmapheresis and immunosuppressive drugs in patients who develop rapidly progressive glomerulonephritis as a complication of bacterial endocarditis.</description><subject>Adult</subject><subject>Antigen-Antibody Complex - analysis</subject><subject>Azathioprine - administration & dosage</subject><subject>Creatinine - blood</subject><subject>Drug Therapy, Combination</subject><subject>Endocarditis, Bacterial - complications</subject><subject>Endocarditis, Bacterial - immunology</subject><subject>Glomerulonephritis - etiology</subject><subject>Glomerulonephritis - pathology</subject><subject>Glomerulonephritis - therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Plasmapheresis</subject><subject>Prednisone - administration & dosage</subject><subject>Streptococcal Infections - complications</subject><subject>Time Factors</subject><issn>0272-6386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRb0AlVL4hEpeIVgEHCd1nCWqeFSqxAJYWxN70hrlYewE1AX_TkJLpZFGmnvvzOgQMo_ZbcxicffKeMYjkUhxLcWNZCxPIn5CpsfxGTkP4YONghATMkkyJnieTcnPqq77pg29cx5DsF9Iuy16cDsKjaGuglCDGyYYbKC2oYNkTbWjzreb_8Smamv0fdU26LbedoMTQmi1hQ4N_bbdlhagO_QWKoqNaTV4M9ouyGkJVcDLQ5-R98eHt-VztH55Wi3v15FOWNpFBuMEQLJCs0JozDUIoXPkzLBSSgDBM7MQkkEqNVvEWSH4EFiknGkJRpbJjFzt9w5ff_YYOlXboLGqoMG2DyoTMuU8yQfjYm_Uvg3BY6mctzX4nYqZGlGrP9RqZKrGGokqPuTmhwN9UaM5pg6ck19pEYEQ</recordid><startdate>19860501</startdate><enddate>19860501</enddate><creator>Rovzar, M A</creator><creator>Logan, J L</creator><creator>Ogden, D A</creator><creator>Graham, A R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860501</creationdate><title>Immunosuppressive therapy and plasmapheresis in rapidly progressive glomerulonephritis associated with bacterial endocarditis</title><author>Rovzar, M A ; Logan, J L ; Ogden, D A ; Graham, A R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-de13aa80bc0b6ce9ca66c9e20d0f88aa627d5680a48c0517b6213a5420c8ad8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Antigen-Antibody Complex - analysis</topic><topic>Azathioprine - administration & dosage</topic><topic>Creatinine - blood</topic><topic>Drug Therapy, Combination</topic><topic>Endocarditis, Bacterial - complications</topic><topic>Endocarditis, Bacterial - immunology</topic><topic>Glomerulonephritis - etiology</topic><topic>Glomerulonephritis - pathology</topic><topic>Glomerulonephritis - therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Plasmapheresis</topic><topic>Prednisone - administration & dosage</topic><topic>Streptococcal Infections - complications</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rovzar, M A</creatorcontrib><creatorcontrib>Logan, J L</creatorcontrib><creatorcontrib>Ogden, D A</creatorcontrib><creatorcontrib>Graham, A R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rovzar, M A</au><au>Logan, J L</au><au>Ogden, D A</au><au>Graham, A R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunosuppressive therapy and plasmapheresis in rapidly progressive glomerulonephritis associated with bacterial endocarditis</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>1986-05-01</date><risdate>1986</risdate><volume>7</volume><issue>5</issue><spage>428</spage><epage>433</epage><pages>428-433</pages><issn>0272-6386</issn><abstract>A 25-year-old male presented with new cardiac murmurs and acute renal insufficiency. Blood cultures grew Streptococcus viridans and appropriate antibiotic therapy was initiated. A renal biopsy revealed diffuse proliferative glomerulonephritis with crescents involving more than 50% of the glomeruli. Treatment with antibiotics, plasmapheresis, and steroids resulted in renal recovery that paralleled reductions in circulating immune complexes. The rationale for this therapeutic approach is discussed, as well as a review of two similar case reports. These experiences suggest a possible role for plasmapheresis and immunosuppressive drugs in patients who develop rapidly progressive glomerulonephritis as a complication of bacterial endocarditis.</abstract><cop>United States</cop><pmid>3706297</pmid><doi>10.1016/S0272-6386(86)80093-2</doi><tpages>6</tpages></addata></record> |
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subjects | Adult Antigen-Antibody Complex - analysis Azathioprine - administration & dosage Creatinine - blood Drug Therapy, Combination Endocarditis, Bacterial - complications Endocarditis, Bacterial - immunology Glomerulonephritis - etiology Glomerulonephritis - pathology Glomerulonephritis - therapy Humans Male Plasmapheresis Prednisone - administration & dosage Streptococcal Infections - complications Time Factors |
title | Immunosuppressive therapy and plasmapheresis in rapidly progressive glomerulonephritis associated with bacterial endocarditis |
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