Chimeric human and rat serotonin transporters reveal domains involved in recognition of transporter ligands

The serotonin transporter (SERT) is a target for many clinically significant drugs, such as cocaine, amphetamine, and antidepressants. The relationship between the structure of SERT and the binding of substrates and antagonists is virtually unknown, despite a large body of data describing the struct...

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Veröffentlicht in:	Molecular pharmacology 1994-11, Vol.46 (5), p.799-807
Hauptverfasser:	Barker, E L, Kimmel, H L, Blakely, R D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antidepressive Agents, Second-Generation - pharmacology Antidepressive Agents, Tricyclic - pharmacology Binding Sites Carrier Proteins - chemistry Carrier Proteins - drug effects Carrier Proteins - metabolism Cocaine - pharmacology Dextroamphetamine - pharmacology HeLa Cells Humans Imipramine - metabolism Membrane Glycoproteins - chemistry Membrane Glycoproteins - drug effects Membrane Glycoproteins - metabolism Membrane Transport Proteins Molecular Sequence Data Nerve Tissue Proteins Rats Recombinant Fusion Proteins - chemistry Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins Species Specificity Structure-Activity Relationship
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