Preoptic lesions increase the display of lordosis by male rats
Male rats do not normally show feminine patterns of sexual behavior even when injected with the ovarian hormones estrogen and progesterone. We find that brain lesions which damage the preoptic-anterior hypothalamic continuum augment the display of lordosis in hormone-treated male rats. The most effe...
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| Veröffentlicht in: | Brain research 1986-04, Vol.370 (1), p.21-28 |
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| creator | Hennessey, Ann C. Wallen, Kim Edwards, David A. |
| description | Male rats do not normally show feminine patterns of sexual behavior even when injected with the ovarian hormones estrogen and progesterone. We find that brain lesions which damage the preoptic-anterior hypothalamic continuum augment the display of lordosis in hormone-treated male rats. The most effectively feminizing brain lesions are ones which bilaterally destroy a substantial portion of the medial preoptic area encompassing the sexually dimorphic nucleus of the preoptic area (SDN-POA). Males with particularly large preoptic lesions are receptive following estrogen treatment and show a progesterone facilitation of receptivity. In this respect, they cannot be behaviorally distinguished from females. Thus, axons originating in and/or passing through the preoptic area apparently inhibit the display of feminine sexual behaviors in males. Preoptic development and lordosis are each predictably affected by perinatal stimulation by testicular hormones, and hormone-stimulated preoptic development may form the neurological basis for some of the defeminizing effects of perinatal hormonal exposure. Our results raise the possibility that the site of this behavioral defeminization is the SDN-POA. |
| doi_str_mv | 10.1016/0006-8993(86)91100-5 |
| format | Article |
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We find that brain lesions which damage the preoptic-anterior hypothalamic continuum augment the display of lordosis in hormone-treated male rats. The most effectively feminizing brain lesions are ones which bilaterally destroy a substantial portion of the medial preoptic area encompassing the sexually dimorphic nucleus of the preoptic area (SDN-POA). Males with particularly large preoptic lesions are receptive following estrogen treatment and show a progesterone facilitation of receptivity. In this respect, they cannot be behaviorally distinguished from females. Thus, axons originating in and/or passing through the preoptic area apparently inhibit the display of feminine sexual behaviors in males. Preoptic development and lordosis are each predictably affected by perinatal stimulation by testicular hormones, and hormone-stimulated preoptic development may form the neurological basis for some of the defeminizing effects of perinatal hormonal exposure. 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Urophysis ; Male ; medial preoptic lesion ; Neural Inhibition ; Orchiectomy ; Other techniques and industries ; Posture ; Preoptic Area - physiology ; Progesterone - physiology ; rat ; Rats ; Sex Characteristics ; Sexual Behavior, Animal - physiology ; Vertebrates: endocrinology</subject><ispartof>Brain research, 1986-04, Vol.370 (1), p.21-28</ispartof><rights>1986 Elsevier Science Publishers B.V. 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We find that brain lesions which damage the preoptic-anterior hypothalamic continuum augment the display of lordosis in hormone-treated male rats. The most effectively feminizing brain lesions are ones which bilaterally destroy a substantial portion of the medial preoptic area encompassing the sexually dimorphic nucleus of the preoptic area (SDN-POA). Males with particularly large preoptic lesions are receptive following estrogen treatment and show a progesterone facilitation of receptivity. In this respect, they cannot be behaviorally distinguished from females. Thus, axons originating in and/or passing through the preoptic area apparently inhibit the display of feminine sexual behaviors in males. Preoptic development and lordosis are each predictably affected by perinatal stimulation by testicular hormones, and hormone-stimulated preoptic development may form the neurological basis for some of the defeminizing effects of perinatal hormonal exposure. Our results raise the possibility that the site of this behavioral defeminization is the SDN-POA.</description><subject>Animals</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Estrogens - physiology</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>feminine sexual behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus, Middle - physiology</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Male</subject><subject>medial preoptic lesion</subject><subject>Neural Inhibition</subject><subject>Orchiectomy</subject><subject>Other techniques and industries</subject><subject>Posture</subject><subject>Preoptic Area - physiology</subject><subject>Progesterone - physiology</subject><subject>rat</subject><subject>Rats</subject><subject>Sex Characteristics</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Vertebrates: endocrinology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rHDEMhk1JSbZp_0ECPoTSHqaVxx_juQRK6BcE2kPuxmPL1GF2vLFmC_vvO9td9pichPQ-EuJh7ErAJwHCfAYA09i-lx-s-dgLAdDoV2wlbNc2plVwxlYn5IK9IXpcWil7OGfnsgMrW7Fit78rls2cAx-RcpmI5ylU9IR8_oM8ZtqMfsdL4mOpsVAmPuz42o_Iq5_pLXud_Ej47lgv2cO3rw93P5r7X99_3n25b4IW7dyE0PapTd0w9OCDjSn2ehARQpDRJqW1RhWXiYktAlqRRBpMNDpFq1QM8pK9P5zd1PK0RZrdOlPAcfQTli25zlgFopMvgkLJXiihF1AdwFALUcXkNjWvfd05AW6v1-3dub07Z437r9ft166P97fDGuNp6ehzyW-Ouafgx1T9FDKdMCtA2w5exKAznVULdnvAcFH7N2N1FDJOAWOuGGYXS37-3X8hIqLN</recordid><startdate>19860402</startdate><enddate>19860402</enddate><creator>Hennessey, Ann C.</creator><creator>Wallen, Kim</creator><creator>Edwards, David A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19860402</creationdate><title>Preoptic lesions increase the display of lordosis by male rats</title><author>Hennessey, Ann C. ; Wallen, Kim ; Edwards, David A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-cc29f2f7bb90ac8dfd95b1d0cc3d8f4555e4d5b16d2e0e81f1fb6d65fd844dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Estrogens - physiology</topic><topic>Exact sciences and technology</topic><topic>Female</topic><topic>feminine sexual behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus, Middle - physiology</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Male</topic><topic>medial preoptic lesion</topic><topic>Neural Inhibition</topic><topic>Orchiectomy</topic><topic>Other techniques and industries</topic><topic>Posture</topic><topic>Preoptic Area - physiology</topic><topic>Progesterone - physiology</topic><topic>rat</topic><topic>Rats</topic><topic>Sex Characteristics</topic><topic>Sexual Behavior, Animal - physiology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hennessey, Ann C.</creatorcontrib><creatorcontrib>Wallen, Kim</creatorcontrib><creatorcontrib>Edwards, David A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hennessey, Ann C.</au><au>Wallen, Kim</au><au>Edwards, David A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoptic lesions increase the display of lordosis by male rats</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1986-04-02</date><risdate>1986</risdate><volume>370</volume><issue>1</issue><spage>21</spage><epage>28</epage><pages>21-28</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Male rats do not normally show feminine patterns of sexual behavior even when injected with the ovarian hormones estrogen and progesterone. We find that brain lesions which damage the preoptic-anterior hypothalamic continuum augment the display of lordosis in hormone-treated male rats. The most effectively feminizing brain lesions are ones which bilaterally destroy a substantial portion of the medial preoptic area encompassing the sexually dimorphic nucleus of the preoptic area (SDN-POA). Males with particularly large preoptic lesions are receptive following estrogen treatment and show a progesterone facilitation of receptivity. In this respect, they cannot be behaviorally distinguished from females. Thus, axons originating in and/or passing through the preoptic area apparently inhibit the display of feminine sexual behaviors in males. Preoptic development and lordosis are each predictably affected by perinatal stimulation by testicular hormones, and hormone-stimulated preoptic development may form the neurological basis for some of the defeminizing effects of perinatal hormonal exposure. Our results raise the possibility that the site of this behavioral defeminization is the SDN-POA.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>3708321</pmid><doi>10.1016/0006-8993(86)91100-5</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Applied sciences Biological and medical sciences Brain Mapping Estrogens - physiology Exact sciences and technology Female feminine sexual behavior Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus, Middle - physiology Hypothalamus. Hypophysis. Epiphysis. Urophysis Male medial preoptic lesion Neural Inhibition Orchiectomy Other techniques and industries Posture Preoptic Area - physiology Progesterone - physiology rat Rats Sex Characteristics Sexual Behavior, Animal - physiology Vertebrates: endocrinology |
| title | Preoptic lesions increase the display of lordosis by male rats |
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