Effects of pantethine on cholesterol synthesis from mevalonate in isolated rat hepatocytes

Results presented here show that when isolated rat hepatocytes are incubated with increasing concentrations of [2- 14C]mevalonolactone, incorporation of the substrate into cholesterol is progressively reduced. Correspondingly, an increase of the incorporation of the substrate into precursors of chol...

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Veröffentlicht in:	Atherosclerosis 1986-04, Vol.60 (1), p.67-77
Hauptverfasser:	Cighetti, G., Del Puppo, M., Paroni, R., Galli, G., Kienle, M.Galli
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carbon Radioisotopes Cholesterol - biosynthesis Cholesterol 7-alpha-Hydroxylase - analysis General and cellular metabolism. Vitamins Hydroxymethylglutaryl-CoA Reductase Inhibitors In Vitro Techniques Liver - drug effects Liver - metabolism Male Medical sciences Mevalonate Mevalonic Acid - metabolism Pantetheine - analogs & derivatives Pantetheine - pharmacology Pantethine Pharmacology. Drug treatments Rat hepatocytes Rats Rats, Inbred Strains Squalene - metabolism Sterol O-Acyltransferase - analysis Sulfhydryl Compounds - pharmacology
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