Variations in the anaerobic faecal flora of ten healthy human volunteers with special reference to the Bacteroides fragilis-group and clostridium difficile
Ninety nine stool specimens of ten healthy human volunteers were collected over a one year period, and processed anaerobically. The individual variations in intestinal colonization with bacteria of the Bacteroides fragilis-group were detected, using the Bacteroides Bile Esculin medium and an identif...
Gespeichert in:
| Veröffentlicht in: | Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology Mikrobiologie und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology, 1986-02, Vol.261 (1), p.43-52 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 52 |
|---|---|
| container_issue | 1 |
| container_start_page | 43 |
| container_title | Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology |
| container_volume | 261 |
| creator | Meijer-Severs, G.J. van Santen, E. |
| description | Ninety nine stool specimens of ten healthy human volunteers were collected over a one year period, and processed anaerobically. The individual variations in intestinal colonization with bacteria of the
Bacteroides fragilis-group were detected, using the Bacteroides Bile Esculin medium and an identification scheme for bile-resistent
Bacteroides species.
Clostridium difficile agar supplemented with cycloserine/cefoxtin was used to detect the incidence of
C. difficile in this group.
The species of the
B. fragilis-group most often detected were:
B. vulgatus (in 31 samples from ten persons),
B. uniformis (22/9),
B. fragilis (19/7).
C. difficile was never detected in this group.
The mean total anaerobic cultural counts (log) of the ten volunteers varied between 9.94 and 10.91. This shows that interindividual variations in anaerobic cultural counts of about one log are common. In spite of these moderate interindividual variations, intraindividual variations in time of up to three log were detected. The mean
Bacteroides cultural counts showed a variation between 8.83 and 10.24. The mean DMCCs of the ten volunteers were between 10.22 and 10.73.
We conclude that at least a three to four log difference from the control samples will be required to establish a significant change in anaerobic cultural count due to antibiotic treatment.
Neunundneunzig Stuhlproben von zehn gesunden freiwilligen Probanden wurden im Zeitraum eines Jahres gesammelt und anaerob verarbeitet. Es wurden individuelle Schwankungen der Darmbesiedlung durch Bakterien der
Bacteroides fragilis-Gruppe unter Verwendung des Bacteroides-Galle-Aesculin-Mediums und eines Identifikationsschemas für galleresistente
Bacteroides-Spezies festgestellt.
Clostridium difficile-Agar unter Zusatz von Cycloserin/Cefoxitin wurde zur Ermittlung der Häufigkeit des Auftretens von
C. difficile in dieser Gruppe verwendet. Die folgenden Arten der
B. fragilis-Gruppe wurden am häufigsten festgestellt:
B. vulgatus (in 31 Proben von 10 Personen),
B. uniformis (22/9),
B. fragilis (19/7). In keinem Fall wurde in dieser Gruppe
C. difficile festgestellt.
Die mittlere Gesamtzahl der anaeroben Kulturen (log) lag bei den zehn Probanden zwischen 9,94 und 10,91. Dies zeigt, daß interindividuelle Schwankungen der Zahl der anaeroben Kulturen von etwa einer Zehnerpotenz üblich sind. Trotz dieser geringen interindividuellen Schwankungen, wurden intraindividuelle Schwankungen im Zeitverlauf bis zu drei Zehnerpotenzen ermittelt. Die mittleren K |
| doi_str_mv | 10.1016/S0176-6724(86)80061-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76838478</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S017667248680061X</els_id><sourcerecordid>76838478</sourcerecordid><originalsourceid>FETCH-LOGICAL-c304t-184ab482127e45854a84b6c69f4fda37d0b96cff2695e23cc24b6e572f173c263</originalsourceid><addsrcrecordid>eNqFUctu3SAQ9aJVGqX5hEgsqqpduAUbA15VbdSXFCmLplV2COMhngqbW8CJ8i392XAfutuwQeI8Zjinqi4Y_cAoEx9_USZFLWTD3ynxXlEqWH37ojo9Pr-qzlP6S8vpOaOtOqlOWkk72cvT6v8fE9FkDEsiuJA8ATGLgRgGtMQZsMYT50M0JDiSYSETGJ-nRzKts1nIffDrkgFiIg-YJ5I2YLFIIjiIsFggOexMvxibiyuOkIiL5g49pvouhnVT5o3E-pByxBHXmYzoHFr08Lp66YxPcH64z6rf377eXP6or66__7z8fFXblvJcM8XNwFXDGgm8Ux03ig_Cit5xN5pWjnTohXWuEX0HTWttU2DoZOOYbG0j2rPq7d53E8O_FVLWMyYL3psFwpq0FKpVXKpC7PZEG0NK5Y96E3E28VEzqrdd6F0Xehu6VkLvutC3RXdxGLAOM4xH1aGFgr854CaVwEs-i8V0pCkpVSO7Qvu0p0EJ4x4h6mRxG_KIEWzWY8BnFnkCLsmrMg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76838478</pqid></control><display><type>article</type><title>Variations in the anaerobic faecal flora of ten healthy human volunteers with special reference to the Bacteroides fragilis-group and clostridium difficile</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Meijer-Severs, G.J. ; van Santen, E.</creator><creatorcontrib>Meijer-Severs, G.J. ; van Santen, E.</creatorcontrib><description>Ninety nine stool specimens of ten healthy human volunteers were collected over a one year period, and processed anaerobically. The individual variations in intestinal colonization with bacteria of the
Bacteroides fragilis-group were detected, using the Bacteroides Bile Esculin medium and an identification scheme for bile-resistent
Bacteroides species.
Clostridium difficile agar supplemented with cycloserine/cefoxtin was used to detect the incidence of
C. difficile in this group.
The species of the
B. fragilis-group most often detected were:
B. vulgatus (in 31 samples from ten persons),
B. uniformis (22/9),
B. fragilis (19/7).
C. difficile was never detected in this group.
The mean total anaerobic cultural counts (log) of the ten volunteers varied between 9.94 and 10.91. This shows that interindividual variations in anaerobic cultural counts of about one log are common. In spite of these moderate interindividual variations, intraindividual variations in time of up to three log were detected. The mean
Bacteroides cultural counts showed a variation between 8.83 and 10.24. The mean DMCCs of the ten volunteers were between 10.22 and 10.73.
We conclude that at least a three to four log difference from the control samples will be required to establish a significant change in anaerobic cultural count due to antibiotic treatment.
Neunundneunzig Stuhlproben von zehn gesunden freiwilligen Probanden wurden im Zeitraum eines Jahres gesammelt und anaerob verarbeitet. Es wurden individuelle Schwankungen der Darmbesiedlung durch Bakterien der
Bacteroides fragilis-Gruppe unter Verwendung des Bacteroides-Galle-Aesculin-Mediums und eines Identifikationsschemas für galleresistente
Bacteroides-Spezies festgestellt.
Clostridium difficile-Agar unter Zusatz von Cycloserin/Cefoxitin wurde zur Ermittlung der Häufigkeit des Auftretens von
C. difficile in dieser Gruppe verwendet. Die folgenden Arten der
B. fragilis-Gruppe wurden am häufigsten festgestellt:
B. vulgatus (in 31 Proben von 10 Personen),
B. uniformis (22/9),
B. fragilis (19/7). In keinem Fall wurde in dieser Gruppe
C. difficile festgestellt.
Die mittlere Gesamtzahl der anaeroben Kulturen (log) lag bei den zehn Probanden zwischen 9,94 und 10,91. Dies zeigt, daß interindividuelle Schwankungen der Zahl der anaeroben Kulturen von etwa einer Zehnerpotenz üblich sind. Trotz dieser geringen interindividuellen Schwankungen, wurden intraindividuelle Schwankungen im Zeitverlauf bis zu drei Zehnerpotenzen ermittelt. Die mittleren Kulturzahlen von
Bacteroides schwankten zwischen 8,83 und 10,24. Die mittleren DMCC-Werte der zehn Probanden lagen zwischen 10,22 und 10,73.
Es wird daraus geschlossen, daß mindestens ein Unterschied von drei bis vier Zehnerpotenzen zu den Kontrollproben nötig ist, um eine signifikante Veränderung der Zahl der anaeroben Kulturen infolge von Antibiotikabehandlung feststellen zu können.</description><identifier>ISSN: 0176-6724</identifier><identifier>DOI: 10.1016/S0176-6724(86)80061-X</identifier><identifier>PMID: 3705797</identifier><language>eng</language><publisher>Stuttgart: Fischer</publisher><subject>Adult ; Anaerobiosis ; Animal, plant and microbial ecology ; Anti-Bacterial Agents - therapeutic use ; Antineoplastic Agents - therapeutic use ; Bacteroides fragilis - growth & development ; Bacteroides fragilis - isolation & purification ; Biological and medical sciences ; Clostridium - growth & development ; Clostridium - isolation & purification ; Feces - microbiology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Intestines - microbiology ; Male ; Microbial ecology ; Normal microflora of man and animals. Rumen</subject><ispartof>Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology, 1986-02, Vol.261 (1), p.43-52</ispartof><rights>1986 Gustav Fischer Verlag, Stuttgart · New York</rights><rights>1986 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c304t-184ab482127e45854a84b6c69f4fda37d0b96cff2695e23cc24b6e572f173c263</citedby><cites>FETCH-LOGICAL-c304t-184ab482127e45854a84b6c69f4fda37d0b96cff2695e23cc24b6e572f173c263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8778275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3705797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meijer-Severs, G.J.</creatorcontrib><creatorcontrib>van Santen, E.</creatorcontrib><title>Variations in the anaerobic faecal flora of ten healthy human volunteers with special reference to the Bacteroides fragilis-group and clostridium difficile</title><title>Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology</title><addtitle>Zentralbl Bakteriol Mikrobiol Hyg A</addtitle><description>Ninety nine stool specimens of ten healthy human volunteers were collected over a one year period, and processed anaerobically. The individual variations in intestinal colonization with bacteria of the
Bacteroides fragilis-group were detected, using the Bacteroides Bile Esculin medium and an identification scheme for bile-resistent
Bacteroides species.
Clostridium difficile agar supplemented with cycloserine/cefoxtin was used to detect the incidence of
C. difficile in this group.
The species of the
B. fragilis-group most often detected were:
B. vulgatus (in 31 samples from ten persons),
B. uniformis (22/9),
B. fragilis (19/7).
C. difficile was never detected in this group.
The mean total anaerobic cultural counts (log) of the ten volunteers varied between 9.94 and 10.91. This shows that interindividual variations in anaerobic cultural counts of about one log are common. In spite of these moderate interindividual variations, intraindividual variations in time of up to three log were detected. The mean
Bacteroides cultural counts showed a variation between 8.83 and 10.24. The mean DMCCs of the ten volunteers were between 10.22 and 10.73.
We conclude that at least a three to four log difference from the control samples will be required to establish a significant change in anaerobic cultural count due to antibiotic treatment.
Neunundneunzig Stuhlproben von zehn gesunden freiwilligen Probanden wurden im Zeitraum eines Jahres gesammelt und anaerob verarbeitet. Es wurden individuelle Schwankungen der Darmbesiedlung durch Bakterien der
Bacteroides fragilis-Gruppe unter Verwendung des Bacteroides-Galle-Aesculin-Mediums und eines Identifikationsschemas für galleresistente
Bacteroides-Spezies festgestellt.
Clostridium difficile-Agar unter Zusatz von Cycloserin/Cefoxitin wurde zur Ermittlung der Häufigkeit des Auftretens von
C. difficile in dieser Gruppe verwendet. Die folgenden Arten der
B. fragilis-Gruppe wurden am häufigsten festgestellt:
B. vulgatus (in 31 Proben von 10 Personen),
B. uniformis (22/9),
B. fragilis (19/7). In keinem Fall wurde in dieser Gruppe
C. difficile festgestellt.
Die mittlere Gesamtzahl der anaeroben Kulturen (log) lag bei den zehn Probanden zwischen 9,94 und 10,91. Dies zeigt, daß interindividuelle Schwankungen der Zahl der anaeroben Kulturen von etwa einer Zehnerpotenz üblich sind. Trotz dieser geringen interindividuellen Schwankungen, wurden intraindividuelle Schwankungen im Zeitverlauf bis zu drei Zehnerpotenzen ermittelt. Die mittleren Kulturzahlen von
Bacteroides schwankten zwischen 8,83 und 10,24. Die mittleren DMCC-Werte der zehn Probanden lagen zwischen 10,22 und 10,73.
Es wird daraus geschlossen, daß mindestens ein Unterschied von drei bis vier Zehnerpotenzen zu den Kontrollproben nötig ist, um eine signifikante Veränderung der Zahl der anaeroben Kulturen infolge von Antibiotikabehandlung feststellen zu können.</description><subject>Adult</subject><subject>Anaerobiosis</subject><subject>Animal, plant and microbial ecology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Bacteroides fragilis - growth & development</subject><subject>Bacteroides fragilis - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Clostridium - growth & development</subject><subject>Clostridium - isolation & purification</subject><subject>Feces - microbiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Intestines - microbiology</subject><subject>Male</subject><subject>Microbial ecology</subject><subject>Normal microflora of man and animals. Rumen</subject><issn>0176-6724</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu3SAQ9aJVGqX5hEgsqqpduAUbA15VbdSXFCmLplV2COMhngqbW8CJ8i392XAfutuwQeI8Zjinqi4Y_cAoEx9_USZFLWTD3ynxXlEqWH37ojo9Pr-qzlP6S8vpOaOtOqlOWkk72cvT6v8fE9FkDEsiuJA8ATGLgRgGtMQZsMYT50M0JDiSYSETGJ-nRzKts1nIffDrkgFiIg-YJ5I2YLFIIjiIsFggOexMvxibiyuOkIiL5g49pvouhnVT5o3E-pByxBHXmYzoHFr08Lp66YxPcH64z6rf377eXP6or66__7z8fFXblvJcM8XNwFXDGgm8Ux03ig_Cit5xN5pWjnTohXWuEX0HTWttU2DoZOOYbG0j2rPq7d53E8O_FVLWMyYL3psFwpq0FKpVXKpC7PZEG0NK5Y96E3E28VEzqrdd6F0Xehu6VkLvutC3RXdxGLAOM4xH1aGFgr854CaVwEs-i8V0pCkpVSO7Qvu0p0EJ4x4h6mRxG_KIEWzWY8BnFnkCLsmrMg</recordid><startdate>198602</startdate><enddate>198602</enddate><creator>Meijer-Severs, G.J.</creator><creator>van Santen, E.</creator><general>Fischer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198602</creationdate><title>Variations in the anaerobic faecal flora of ten healthy human volunteers with special reference to the Bacteroides fragilis-group and clostridium difficile</title><author>Meijer-Severs, G.J. ; van Santen, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-184ab482127e45854a84b6c69f4fda37d0b96cff2695e23cc24b6e572f173c263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Anaerobiosis</topic><topic>Animal, plant and microbial ecology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Bacteroides fragilis - growth & development</topic><topic>Bacteroides fragilis - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Clostridium - growth & development</topic><topic>Clostridium - isolation & purification</topic><topic>Feces - microbiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Intestines - microbiology</topic><topic>Male</topic><topic>Microbial ecology</topic><topic>Normal microflora of man and animals. Rumen</topic><toplevel>online_resources</toplevel><creatorcontrib>Meijer-Severs, G.J.</creatorcontrib><creatorcontrib>van Santen, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meijer-Severs, G.J.</au><au>van Santen, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variations in the anaerobic faecal flora of ten healthy human volunteers with special reference to the Bacteroides fragilis-group and clostridium difficile</atitle><jtitle>Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology</jtitle><addtitle>Zentralbl Bakteriol Mikrobiol Hyg A</addtitle><date>1986-02</date><risdate>1986</risdate><volume>261</volume><issue>1</issue><spage>43</spage><epage>52</epage><pages>43-52</pages><issn>0176-6724</issn><abstract>Ninety nine stool specimens of ten healthy human volunteers were collected over a one year period, and processed anaerobically. The individual variations in intestinal colonization with bacteria of the
Bacteroides fragilis-group were detected, using the Bacteroides Bile Esculin medium and an identification scheme for bile-resistent
Bacteroides species.
Clostridium difficile agar supplemented with cycloserine/cefoxtin was used to detect the incidence of
C. difficile in this group.
The species of the
B. fragilis-group most often detected were:
B. vulgatus (in 31 samples from ten persons),
B. uniformis (22/9),
B. fragilis (19/7).
C. difficile was never detected in this group.
The mean total anaerobic cultural counts (log) of the ten volunteers varied between 9.94 and 10.91. This shows that interindividual variations in anaerobic cultural counts of about one log are common. In spite of these moderate interindividual variations, intraindividual variations in time of up to three log were detected. The mean
Bacteroides cultural counts showed a variation between 8.83 and 10.24. The mean DMCCs of the ten volunteers were between 10.22 and 10.73.
We conclude that at least a three to four log difference from the control samples will be required to establish a significant change in anaerobic cultural count due to antibiotic treatment.
Neunundneunzig Stuhlproben von zehn gesunden freiwilligen Probanden wurden im Zeitraum eines Jahres gesammelt und anaerob verarbeitet. Es wurden individuelle Schwankungen der Darmbesiedlung durch Bakterien der
Bacteroides fragilis-Gruppe unter Verwendung des Bacteroides-Galle-Aesculin-Mediums und eines Identifikationsschemas für galleresistente
Bacteroides-Spezies festgestellt.
Clostridium difficile-Agar unter Zusatz von Cycloserin/Cefoxitin wurde zur Ermittlung der Häufigkeit des Auftretens von
C. difficile in dieser Gruppe verwendet. Die folgenden Arten der
B. fragilis-Gruppe wurden am häufigsten festgestellt:
B. vulgatus (in 31 Proben von 10 Personen),
B. uniformis (22/9),
B. fragilis (19/7). In keinem Fall wurde in dieser Gruppe
C. difficile festgestellt.
Die mittlere Gesamtzahl der anaeroben Kulturen (log) lag bei den zehn Probanden zwischen 9,94 und 10,91. Dies zeigt, daß interindividuelle Schwankungen der Zahl der anaeroben Kulturen von etwa einer Zehnerpotenz üblich sind. Trotz dieser geringen interindividuellen Schwankungen, wurden intraindividuelle Schwankungen im Zeitverlauf bis zu drei Zehnerpotenzen ermittelt. Die mittleren Kulturzahlen von
Bacteroides schwankten zwischen 8,83 und 10,24. Die mittleren DMCC-Werte der zehn Probanden lagen zwischen 10,22 und 10,73.
Es wird daraus geschlossen, daß mindestens ein Unterschied von drei bis vier Zehnerpotenzen zu den Kontrollproben nötig ist, um eine signifikante Veränderung der Zahl der anaeroben Kulturen infolge von Antibiotikabehandlung feststellen zu können.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Fischer</pub><pmid>3705797</pmid><doi>10.1016/S0176-6724(86)80061-X</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0176-6724 |
| ispartof | Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology, 1986-02, Vol.261 (1), p.43-52 |
| issn | 0176-6724 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76838478 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Anaerobiosis Animal, plant and microbial ecology Anti-Bacterial Agents - therapeutic use Antineoplastic Agents - therapeutic use Bacteroides fragilis - growth & development Bacteroides fragilis - isolation & purification Biological and medical sciences Clostridium - growth & development Clostridium - isolation & purification Feces - microbiology Female Fundamental and applied biological sciences. Psychology Humans Intestines - microbiology Male Microbial ecology Normal microflora of man and animals. Rumen |
| title | Variations in the anaerobic faecal flora of ten healthy human volunteers with special reference to the Bacteroides fragilis-group and clostridium difficile |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T00%3A09%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Variations%20in%20the%20anaerobic%20faecal%20flora%20of%20ten%20healthy%20human%20volunteers%20with%20special%20reference%20to%20the%20Bacteroides%20fragilis-group%20and%20clostridium%20difficile&rft.jtitle=Zentralblatt%20f%C3%BCr%20Bakteriologie,%20Mikrobiologie%20und%20Hygiene.%20Series%20A,%20Medical%20microbiology,%20infectious%20diseases,%20virology,%20parasitology&rft.au=Meijer-Severs,%20G.J.&rft.date=1986-02&rft.volume=261&rft.issue=1&rft.spage=43&rft.epage=52&rft.pages=43-52&rft.issn=0176-6724&rft_id=info:doi/10.1016/S0176-6724(86)80061-X&rft_dat=%3Cproquest_cross%3E76838478%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76838478&rft_id=info:pmid/3705797&rft_els_id=S017667248680061X&rfr_iscdi=true |