INFLUENCE OF ISOFLURANE ON RENAL AND INTESTINAL VASCULAR RESPONSES TO STRESS
Renal and intestinal vasoconstrictor responses elicited by either hypothalamic defence alarm area activation or stimulation of somatic and isceral afferents were studied in 17 cats. In part I, the circulatory adjustments during 2% (end-tidal) isoflurane plus 70 % nitrous oxide in oxygen were compare...
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| Veröffentlicht in: | British journal of anaesthesia : BJA 1986-06, Vol.58 (6), p.630-638 |
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| creator | ÖSTMAN, M. BIBER, B. MARTNER, J. REIZ, S. |
| description | Renal and intestinal vasoconstrictor responses elicited by either hypothalamic defence alarm area activation or stimulation of somatic and isceral afferents were studied in 17 cats. In part I, the circulatory adjustments during 2% (end-tidal) isoflurane plus 70 % nitrous oxide in oxygen were compared with a medium-dose fentanyl in 70% nitrous oxide-oxygen sequence which was supplemented by diazepam. In part II, three end-tidal concentrations of isoflurane (1.4%, 2% and 3%) plus nitrous oxide in oxygen were evaluated before and after pre-treatment with droperidol 200 fig kg−1. During fentanyl-dia-zepam anaesthesia, intense vasoconstrictor responses with associated decreases in renal and intestinal blood flows were observed. Isoflurane 2% counteracted this reflex vasoconstriction, particularly in the renal vascular bed. The pressor and soconstrictor responses were suppressed by isoflurane in a dose-dependent fashion. After the administration of droperidol, the vascularbeds were unaffected by noxious stimulation. It is concluded that isoflurane blunts stress-related vasoconstriction in a dose-dependent fashion, especially in the renal, but also in the intestinal, circulation. Droperidol adds to the vasodilatory effect of isoflurane. |
| doi_str_mv | 10.1093/bja/58.6.630 |
| format | Article |
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In part I, the circulatory adjustments during 2% (end-tidal) isoflurane plus 70 % nitrous oxide in oxygen were compared with a medium-dose fentanyl in 70% nitrous oxide-oxygen sequence which was supplemented by diazepam. In part II, three end-tidal concentrations of isoflurane (1.4%, 2% and 3%) plus nitrous oxide in oxygen were evaluated before and after pre-treatment with droperidol 200 fig kg−1. During fentanyl-dia-zepam anaesthesia, intense vasoconstrictor responses with associated decreases in renal and intestinal blood flows were observed. Isoflurane 2% counteracted this reflex vasoconstriction, particularly in the renal vascular bed. The pressor and soconstrictor responses were suppressed by isoflurane in a dose-dependent fashion. After the administration of droperidol, the vascularbeds were unaffected by noxious stimulation. It is concluded that isoflurane blunts stress-related vasoconstriction in a dose-dependent fashion, especially in the renal, but also in the intestinal, circulation. Droperidol adds to the vasodilatory effect of isoflurane.</description><identifier>ISSN: 0007-0912</identifier><identifier>EISSN: 1471-6771</identifier><identifier>DOI: 10.1093/bja/58.6.630</identifier><identifier>PMID: 3707801</identifier><identifier>CODEN: BJANAD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anesthetics. Neuromuscular blocking agents ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Cats ; Droperidol - pharmacology ; Hemodynamics - drug effects ; Intestines - blood supply ; Isoflurane - pharmacology ; Medical sciences ; Methyl Ethers - pharmacology ; Neuropharmacology ; Pharmacology. Drug treatments ; Regional Blood Flow - drug effects ; Renal Circulation - drug effects ; Stress, Physiological - physiopathology ; Surgical Procedures, Operative ; Vasoconstriction - drug effects</subject><ispartof>British journal of anaesthesia : BJA, 1986-06, Vol.58 (6), p.630-638</ispartof><rights>1986</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-27f9785707e5b2889e5418caaadc3f1e806d09193d34ea59e3af26723fbde76e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8653696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3707801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ÖSTMAN, M.</creatorcontrib><creatorcontrib>BIBER, B.</creatorcontrib><creatorcontrib>MARTNER, J.</creatorcontrib><creatorcontrib>REIZ, S.</creatorcontrib><title>INFLUENCE OF ISOFLURANE ON RENAL AND INTESTINAL VASCULAR RESPONSES TO STRESS</title><title>British journal of anaesthesia : BJA</title><addtitle>Br J Anaesth</addtitle><description>Renal and intestinal vasoconstrictor responses elicited by either hypothalamic defence alarm area activation or stimulation of somatic and isceral afferents were studied in 17 cats. In part I, the circulatory adjustments during 2% (end-tidal) isoflurane plus 70 % nitrous oxide in oxygen were compared with a medium-dose fentanyl in 70% nitrous oxide-oxygen sequence which was supplemented by diazepam. In part II, three end-tidal concentrations of isoflurane (1.4%, 2% and 3%) plus nitrous oxide in oxygen were evaluated before and after pre-treatment with droperidol 200 fig kg−1. During fentanyl-dia-zepam anaesthesia, intense vasoconstrictor responses with associated decreases in renal and intestinal blood flows were observed. Isoflurane 2% counteracted this reflex vasoconstriction, particularly in the renal vascular bed. The pressor and soconstrictor responses were suppressed by isoflurane in a dose-dependent fashion. After the administration of droperidol, the vascularbeds were unaffected by noxious stimulation. It is concluded that isoflurane blunts stress-related vasoconstriction in a dose-dependent fashion, especially in the renal, but also in the intestinal, circulation. Droperidol adds to the vasodilatory effect of isoflurane.</description><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cats</subject><subject>Droperidol - pharmacology</subject><subject>Hemodynamics - drug effects</subject><subject>Intestines - blood supply</subject><subject>Isoflurane - pharmacology</subject><subject>Medical sciences</subject><subject>Methyl Ethers - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Regional Blood Flow - drug effects</subject><subject>Renal Circulation - drug effects</subject><subject>Stress, Physiological - physiopathology</subject><subject>Surgical Procedures, Operative</subject><subject>Vasoconstriction - drug effects</subject><issn>0007-0912</issn><issn>1471-6771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtr20AUhYfSkDpOd90WtChdRfaMRvPQUshyLBCSseQSuhnGoytQ6kc6Y4f033eCjVdZXQ7n43L4EPpG8ITghE43z3rK5IRPOMWf0IjEgoRcCPIZjTDGIsQJib6gO-eeMSYiStgtuqUCC4nJCJVFNS_XeZXlQT0Piqb2aZVWPlXBKq_SMkirWVBUbd60xXv8lTbZukxXvm2WddXkTdDWQdP62Nyjm15vHXy93DFaz_M2W4Rl_VhkaRmamMpjGIk-EZL5CcA2kZQJsJhIo7XuDO0JSMw7PzqhHY1BswSo7iMuItpvOhAc6Bj9PP99sYe_J3BHtRucge1W7-FwckpwSSWOsQcfzqCxB-cs9OrFDjtt_ymC1bs85eUpJhVXXp7Hv1_-njY76K7wxZbvf1x67Yze9lbvzeCumOSM8oR7LDxjgzvC27XW9o_iggqmFk-_1TLCks-eWrX0PD_z4J29DmCVMwPsDXSDBXNU3WH4eO9_s8aRRA</recordid><startdate>19860601</startdate><enddate>19860601</enddate><creator>ÖSTMAN, M.</creator><creator>BIBER, B.</creator><creator>MARTNER, J.</creator><creator>REIZ, S.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860601</creationdate><title>INFLUENCE OF ISOFLURANE ON RENAL AND INTESTINAL VASCULAR RESPONSES TO STRESS</title><author>ÖSTMAN, M. ; BIBER, B. ; MARTNER, J. ; REIZ, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-27f9785707e5b2889e5418caaadc3f1e806d09193d34ea59e3af26723fbde76e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cats</topic><topic>Droperidol - pharmacology</topic><topic>Hemodynamics - drug effects</topic><topic>Intestines - blood supply</topic><topic>Isoflurane - pharmacology</topic><topic>Medical sciences</topic><topic>Methyl Ethers - pharmacology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Regional Blood Flow - drug effects</topic><topic>Renal Circulation - drug effects</topic><topic>Stress, Physiological - physiopathology</topic><topic>Surgical Procedures, Operative</topic><topic>Vasoconstriction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ÖSTMAN, M.</creatorcontrib><creatorcontrib>BIBER, B.</creatorcontrib><creatorcontrib>MARTNER, J.</creatorcontrib><creatorcontrib>REIZ, S.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of anaesthesia : BJA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ÖSTMAN, M.</au><au>BIBER, B.</au><au>MARTNER, J.</au><au>REIZ, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>INFLUENCE OF ISOFLURANE ON RENAL AND INTESTINAL VASCULAR RESPONSES TO STRESS</atitle><jtitle>British journal of anaesthesia : BJA</jtitle><addtitle>Br J Anaesth</addtitle><date>1986-06-01</date><risdate>1986</risdate><volume>58</volume><issue>6</issue><spage>630</spage><epage>638</epage><pages>630-638</pages><issn>0007-0912</issn><eissn>1471-6771</eissn><coden>BJANAD</coden><abstract>Renal and intestinal vasoconstrictor responses elicited by either hypothalamic defence alarm area activation or stimulation of somatic and isceral afferents were studied in 17 cats. In part I, the circulatory adjustments during 2% (end-tidal) isoflurane plus 70 % nitrous oxide in oxygen were compared with a medium-dose fentanyl in 70% nitrous oxide-oxygen sequence which was supplemented by diazepam. In part II, three end-tidal concentrations of isoflurane (1.4%, 2% and 3%) plus nitrous oxide in oxygen were evaluated before and after pre-treatment with droperidol 200 fig kg−1. During fentanyl-dia-zepam anaesthesia, intense vasoconstrictor responses with associated decreases in renal and intestinal blood flows were observed. Isoflurane 2% counteracted this reflex vasoconstriction, particularly in the renal vascular bed. The pressor and soconstrictor responses were suppressed by isoflurane in a dose-dependent fashion. After the administration of droperidol, the vascularbeds were unaffected by noxious stimulation. It is concluded that isoflurane blunts stress-related vasoconstriction in a dose-dependent fashion, especially in the renal, but also in the intestinal, circulation. Droperidol adds to the vasodilatory effect of isoflurane.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3707801</pmid><doi>10.1093/bja/58.6.630</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals Digital Archive legacy; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Blood Pressure - drug effects Cats Droperidol - pharmacology Hemodynamics - drug effects Intestines - blood supply Isoflurane - pharmacology Medical sciences Methyl Ethers - pharmacology Neuropharmacology Pharmacology. Drug treatments Regional Blood Flow - drug effects Renal Circulation - drug effects Stress, Physiological - physiopathology Surgical Procedures, Operative Vasoconstriction - drug effects |
| title | INFLUENCE OF ISOFLURANE ON RENAL AND INTESTINAL VASCULAR RESPONSES TO STRESS |
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