The cytotoxicity of thioguanine vs mercaptopurine in acute lymphoblastic leukemia

The use of mercaptopurine (MP) rather than thioguanine (TG) in the treatment of childhood acute lymphoblastic leukemia (ALL) has occurred for historical reasons, but does not have a pharmacologic basis. The purpose of this study was to begin to address whether TG would be more efficacious than MP in...

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Veröffentlicht in:	Leukemia research 1994-11, Vol.18 (11), p.805-810
Hauptverfasser:	Adamson, Peter C., Poplack, David G., Balis, Frank M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Cell Survival - drug effects Child Child, Preschool childhood leukemia Drug Screening Assays, Antitumor Humans Mercaptopurine - pharmacology Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology schedule dependence Thioguanine - pharmacology Thiopurines Time Factors Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - pathology
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