Aspartyl alpha-((1-phenyl-3-(trifluoromethyl)-pyrazol-5-yl)oxy)methyl ketones as interleukin-1 beta converting enzyme inhibitors. Significance of the P1 and P3 amido nitrogens for enzyme-peptide inhibitor binding

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1994-11, Vol.37 (23), p.3863-3866
Hauptverfasser:	Dolle, R E, Singh, J, Rinker, J, Hoyer, D, Prasad, C V, Graybill, T L, Salvino, J M, Helaszek, C T, Miller, R E, Ator, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amino Acid Sequence Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Aspartic Acid - pharmacology Caspase 1 Cysteine Endopeptidases - drug effects Cysteine Endopeptidases - metabolism Cysteine Proteinase Inhibitors - metabolism Cysteine Proteinase Inhibitors - pharmacology Ketones - metabolism Ketones - pharmacology Molecular Sequence Data Nitrogen - chemistry Structure-Activity Relationship
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