Co-existence of glicentin and peptide YY in colorectal L-cells in cat and man. An electron microscopic study
Electron microscopic immunocytochemistry using protein A-gold labelling of ultrathin sections revealed immunoreactive glicentin (gut-type glucagon) and peptide YY (PYY) in virtually all secretory granules in a population of L-type endocrine cells in feline colon and human rectum. The granules of the...
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| Veröffentlicht in: | Regulatory peptides 1986-02, Vol.13 (3), p.283-291 |
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| creator | Böttcher, G. Alumets, J. Håkanson, R. Sundler, F. |
| description | Electron microscopic immunocytochemistry using protein A-gold labelling of ultrathin sections revealed immunoreactive glicentin (gut-type glucagon) and peptide YY (PYY) in virtually all secretory granules in a population of L-type endocrine cells in feline colon and human rectum. The granules of the human glicentin/PYY cells were considerably smaller in size than those in the cat. In both species the results indicate co-existence of glicentin and PYY in the same secretory granules, despite the probable derivation of the two peptides from two different precursors. |
| doi_str_mv | 10.1016/0167-0115(86)90046-7 |
| format | Article |
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In both species the results indicate co-existence of glicentin and PYY in the same secretory granules, despite the probable derivation of the two peptides from two different precursors.</description><identifier>ISSN: 0167-0115</identifier><identifier>EISSN: 1873-1686</identifier><identifier>DOI: 10.1016/0167-0115(86)90046-7</identifier><identifier>PMID: 3754646</identifier><identifier>CODEN: REPPDY</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Cats ; Colon - analysis ; Colon - ultrastructure ; Cytoplasmic Granules - analysis ; Cytoplasmic Granules - ultrastructure ; EM-immunocytochemistry ; Fundamental and applied biological sciences. Psychology ; Gastrointestinal hormones ; glicentin ; Glucagon - analysis ; Glucagon - immunology ; Gold ; gut endocrine cells ; gut hormones ; Humans ; Immune Sera ; immunogold ; Microscopy, Electron ; peptide co-existence ; Peptide YY ; Peptides - analysis ; Peptides - immunology ; Proglucagon ; Protein Precursors - analysis ; Protein Precursors - immunology ; Rectum - analysis ; Rectum - ultrastructure ; Species Specificity ; Staphylococcal Protein A ; Vertebrates: digestive system</subject><ispartof>Regulatory peptides, 1986-02, Vol.13 (3), p.283-291</ispartof><rights>1986</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c367t-ff9c414dfa48294dde9bfa6df9b999e72a24a0e663deb07c7b653701d84d29663</citedby><cites>FETCH-LOGICAL-c367t-ff9c414dfa48294dde9bfa6df9b999e72a24a0e663deb07c7b653701d84d29663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0167011586900467$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8801435$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3754646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Böttcher, G.</creatorcontrib><creatorcontrib>Alumets, J.</creatorcontrib><creatorcontrib>Håkanson, R.</creatorcontrib><creatorcontrib>Sundler, F.</creatorcontrib><title>Co-existence of glicentin and peptide YY in colorectal L-cells in cat and man. An electron microscopic study</title><title>Regulatory peptides</title><addtitle>Regul Pept</addtitle><description>Electron microscopic immunocytochemistry using protein A-gold labelling of ultrathin sections revealed immunoreactive glicentin (gut-type glucagon) and peptide YY (PYY) in virtually all secretory granules in a population of L-type endocrine cells in feline colon and human rectum. The granules of the human glicentin/PYY cells were considerably smaller in size than those in the cat. In both species the results indicate co-existence of glicentin and PYY in the same secretory granules, despite the probable derivation of the two peptides from two different precursors.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Colon - analysis</subject><subject>Colon - ultrastructure</subject><subject>Cytoplasmic Granules - analysis</subject><subject>Cytoplasmic Granules - ultrastructure</subject><subject>EM-immunocytochemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal hormones</subject><subject>glicentin</subject><subject>Glucagon - analysis</subject><subject>Glucagon - immunology</subject><subject>Gold</subject><subject>gut endocrine cells</subject><subject>gut hormones</subject><subject>Humans</subject><subject>Immune Sera</subject><subject>immunogold</subject><subject>Microscopy, Electron</subject><subject>peptide co-existence</subject><subject>Peptide YY</subject><subject>Peptides - analysis</subject><subject>Peptides - immunology</subject><subject>Proglucagon</subject><subject>Protein Precursors - analysis</subject><subject>Protein Precursors - immunology</subject><subject>Rectum - analysis</subject><subject>Rectum - ultrastructure</subject><subject>Species Specificity</subject><subject>Staphylococcal Protein A</subject><subject>Vertebrates: digestive system</subject><issn>0167-0115</issn><issn>1873-1686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo67j6DxRyENFDr0l3Oh8XYRn8ggUvethTSCcViaSTNukR99-bnhnm6CEEqp4qXp5C6CUlN5RQ_r490RFKx7eSv1OEMN6JR2hHpRg6yiV_jHYX5Cl6VusvQugoxHCFrgYxMs74DsV97uBvqCskCzh7_DMGC2kNCZvk8ALLGhzg-3vcKjbHXMCuJuK7zkKM9Vg165GdTbrBtwlDbEjJCc_BllxtXoLFdT24h-foiTexwovzf41-fPr4ff-lu_v2-ev-tu0cuFg775VllDlvmOwVcw7U5A13Xk1KKRC96ZkhwPngYCLCiomPgyDUSeZ61crX6M1p71Ly7wPUVc-hbnlNgnyoWnDZS8ZpA9kJ3ILWAl4vJcymPGhK9CZZbwb1ZlBLro-StWhjr877D9MM7jJ0ttr6r899U62JvphkQ71gUhLKhrFhH04YNBd_AhRdbdju4MJmWbsc_p_jHwMVmF4</recordid><startdate>198602</startdate><enddate>198602</enddate><creator>Böttcher, G.</creator><creator>Alumets, J.</creator><creator>Håkanson, R.</creator><creator>Sundler, F.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198602</creationdate><title>Co-existence of glicentin and peptide YY in colorectal L-cells in cat and man. An electron microscopic study</title><author>Böttcher, G. ; Alumets, J. ; Håkanson, R. ; Sundler, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-ff9c414dfa48294dde9bfa6df9b999e72a24a0e663deb07c7b653701d84d29663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Colon - analysis</topic><topic>Colon - ultrastructure</topic><topic>Cytoplasmic Granules - analysis</topic><topic>Cytoplasmic Granules - ultrastructure</topic><topic>EM-immunocytochemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal hormones</topic><topic>glicentin</topic><topic>Glucagon - analysis</topic><topic>Glucagon - immunology</topic><topic>Gold</topic><topic>gut endocrine cells</topic><topic>gut hormones</topic><topic>Humans</topic><topic>Immune Sera</topic><topic>immunogold</topic><topic>Microscopy, Electron</topic><topic>peptide co-existence</topic><topic>Peptide YY</topic><topic>Peptides - analysis</topic><topic>Peptides - immunology</topic><topic>Proglucagon</topic><topic>Protein Precursors - analysis</topic><topic>Protein Precursors - immunology</topic><topic>Rectum - analysis</topic><topic>Rectum - ultrastructure</topic><topic>Species Specificity</topic><topic>Staphylococcal Protein A</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Böttcher, G.</creatorcontrib><creatorcontrib>Alumets, J.</creatorcontrib><creatorcontrib>Håkanson, R.</creatorcontrib><creatorcontrib>Sundler, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Regulatory peptides</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Böttcher, G.</au><au>Alumets, J.</au><au>Håkanson, R.</au><au>Sundler, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Co-existence of glicentin and peptide YY in colorectal L-cells in cat and man. An electron microscopic study</atitle><jtitle>Regulatory peptides</jtitle><addtitle>Regul Pept</addtitle><date>1986-02</date><risdate>1986</risdate><volume>13</volume><issue>3</issue><spage>283</spage><epage>291</epage><pages>283-291</pages><issn>0167-0115</issn><eissn>1873-1686</eissn><coden>REPPDY</coden><abstract>Electron microscopic immunocytochemistry using protein A-gold labelling of ultrathin sections revealed immunoreactive glicentin (gut-type glucagon) and peptide YY (PYY) in virtually all secretory granules in a population of L-type endocrine cells in feline colon and human rectum. The granules of the human glicentin/PYY cells were considerably smaller in size than those in the cat. In both species the results indicate co-existence of glicentin and PYY in the same secretory granules, despite the probable derivation of the two peptides from two different precursors.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>3754646</pmid><doi>10.1016/0167-0115(86)90046-7</doi><tpages>9</tpages></addata></record> |
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| ispartof | Regulatory peptides, 1986-02, Vol.13 (3), p.283-291 |
| issn | 0167-0115 1873-1686 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Cats Colon - analysis Colon - ultrastructure Cytoplasmic Granules - analysis Cytoplasmic Granules - ultrastructure EM-immunocytochemistry Fundamental and applied biological sciences. Psychology Gastrointestinal hormones glicentin Glucagon - analysis Glucagon - immunology Gold gut endocrine cells gut hormones Humans Immune Sera immunogold Microscopy, Electron peptide co-existence Peptide YY Peptides - analysis Peptides - immunology Proglucagon Protein Precursors - analysis Protein Precursors - immunology Rectum - analysis Rectum - ultrastructure Species Specificity Staphylococcal Protein A Vertebrates: digestive system |
| title | Co-existence of glicentin and peptide YY in colorectal L-cells in cat and man. An electron microscopic study |
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