Synthesis of Oxadiazolidinedione Derivatives as Quisqualic Acid Analogs and Their Evaluation at a Quisqualate-Sensitized Site in the Rat Hippocampus

The ability of quisqualic acid (1) to sensitize neurons to depolarization by omega-phosphono alpha-amino acid analogues of excitatory amino acids is a highly specific phenomenon and is termed the QUIS effect. In an attempt to elucidate the structure-activity relationships for this sensitization, ana...

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Veröffentlicht in:	Journal of medicinal chemistry 1994-11, Vol.37 (23), p.3939-3946
Hauptverfasser:	Venkatraman, Shankar, Roon, Robert J., Schulte, Marvin K., Koerner, James F., Johnson, Rodney L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemistry Exact sciences and technology Glutamatergic system (aspartate and other excitatory aminoacids) Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Hippocampus - drug effects Hippocampus - metabolism In Vitro Techniques Male Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Organic chemistry Oxadiazoles - chemistry Pharmacology. Drug treatments Preparations and properties Quisqualic Acid - analogs & derivatives Quisqualic Acid - chemical synthesis Quisqualic Acid - pharmacology Rats Rats, Sprague-Dawley Structure-Activity Relationship
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