Relation between Work and Phosphate Metabolite in the in Vivo Paced Mammalian Heart
Nuclear magnetic resonance (NMR) spectroscopy was used to monitor, on a beat-to-beat basis, the concentration of creatine phosphate and adenosine triphosphate during alterations in the work output of canine hearts in vivo. Over a wide range of rate-pressure products (5,000 to 25,000 mmHg/min), the r...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1986-05, Vol.232 (4754), p.1121-1123 |
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| creator | Balaban, R. S. Kantor, H. L. Katz, L. A. Briggs, R. W. |
| description | Nuclear magnetic resonance (NMR) spectroscopy was used to monitor, on a beat-to-beat basis, the concentration of creatine phosphate and adenosine triphosphate during alterations in the work output of canine hearts in vivo. Over a wide range of rate-pressure products (5,000 to 25,000 mmHg/min), the relative amounts of creatine phosphate and adenosine triphosphate within the heart remained constant. The relative concentration of free adenosine diphosphate was calculated under the reasonable assumption that the creatine kinase--catalyzed reaction is near equilibrium in this tissue. The free concentration of adenosine diphosphate also did not change over this range of rate-pressure products. The data demonstrate that the concentration of these compounds is highly regulated in vivo and suggest that factors other than their concentration may be involved in the modulation of steady-state myocardial work output with oxygen consumption. |
| doi_str_mv | 10.1126/science.3704638 |
| format | Article |
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S. ; Kantor, H. L. ; Katz, L. A. ; Briggs, R. W.</creator><creatorcontrib>Balaban, R. S. ; Kantor, H. L. ; Katz, L. A. ; Briggs, R. W.</creatorcontrib><description>Nuclear magnetic resonance (NMR) spectroscopy was used to monitor, on a beat-to-beat basis, the concentration of creatine phosphate and adenosine triphosphate during alterations in the work output of canine hearts in vivo. Over a wide range of rate-pressure products (5,000 to 25,000 mmHg/min), the relative amounts of creatine phosphate and adenosine triphosphate within the heart remained constant. The relative concentration of free adenosine diphosphate was calculated under the reasonable assumption that the creatine kinase--catalyzed reaction is near equilibrium in this tissue. The free concentration of adenosine diphosphate also did not change over this range of rate-pressure products. The data demonstrate that the concentration of these compounds is highly regulated in vivo and suggest that factors other than their concentration may be involved in the modulation of steady-state myocardial work output with oxygen consumption.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.3704638</identifier><identifier>PMID: 3704638</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Adenosine Diphosphate - analysis ; Adenosine Diphosphate - metabolism ; Adenosine monophosphate ; Adenosine Triphosphate - analysis ; Adenosine Triphosphate - metabolism ; Adenylic acid ; Anatomy & physiology ; Biochemistry ; Biological and medical sciences ; Cardiovascular research ; Creatine ; Energy metabolism ; Fundamental and applied biological sciences. Psychology ; Heart ; Heart - physiology ; Heart Rate ; Magnetic Resonance Spectroscopy ; Magnets ; Medical research ; Metabolic regulation ; Metabolism ; Mitochondria ; Mitochondria, Heart - metabolism ; Myocardium - analysis ; Myocardium - metabolism ; Nuclear energy ; Oxygen Consumption ; Phosphates ; Phosphocreatine - analysis ; Phosphocreatine - metabolism ; Phosphorus ; Phosphorus (Chemical element) ; Phosphorus metabolism ; Respiration ; Systole ; Vertebrates: cardiovascular system</subject><ispartof>Science (American Association for the Advancement of Science), 1986-05, Vol.232 (4754), p.1121-1123</ispartof><rights>Copyright 1986 The American Association for the Advancement of Science</rights><rights>1986 INIST-CNRS</rights><rights>COPYRIGHT 1986 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1986 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science May 30, 1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c649t-7fe6a5dff96e92966536e3ce901209256c4b81f4d1bef423d9b50db3717bc03b3</citedby><cites>FETCH-LOGICAL-c649t-7fe6a5dff96e92966536e3ce901209256c4b81f4d1bef423d9b50db3717bc03b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1696265$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1696265$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,2873,2874,27911,27912,58004,58237</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8768542$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3704638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balaban, R. S.</creatorcontrib><creatorcontrib>Kantor, H. L.</creatorcontrib><creatorcontrib>Katz, L. A.</creatorcontrib><creatorcontrib>Briggs, R. W.</creatorcontrib><title>Relation between Work and Phosphate Metabolite in the in Vivo Paced Mammalian Heart</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Nuclear magnetic resonance (NMR) spectroscopy was used to monitor, on a beat-to-beat basis, the concentration of creatine phosphate and adenosine triphosphate during alterations in the work output of canine hearts in vivo. Over a wide range of rate-pressure products (5,000 to 25,000 mmHg/min), the relative amounts of creatine phosphate and adenosine triphosphate within the heart remained constant. The relative concentration of free adenosine diphosphate was calculated under the reasonable assumption that the creatine kinase--catalyzed reaction is near equilibrium in this tissue. The free concentration of adenosine diphosphate also did not change over this range of rate-pressure products. The data demonstrate that the concentration of these compounds is highly regulated in vivo and suggest that factors other than their concentration may be involved in the modulation of steady-state myocardial work output with oxygen consumption.</description><subject>Adenosine Diphosphate - analysis</subject><subject>Adenosine Diphosphate - metabolism</subject><subject>Adenosine monophosphate</subject><subject>Adenosine Triphosphate - analysis</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Adenylic acid</subject><subject>Anatomy & physiology</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular research</subject><subject>Creatine</subject><subject>Energy metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heart</subject><subject>Heart - physiology</subject><subject>Heart Rate</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Magnets</subject><subject>Medical research</subject><subject>Metabolic regulation</subject><subject>Metabolism</subject><subject>Mitochondria</subject><subject>Mitochondria, Heart - metabolism</subject><subject>Myocardium - analysis</subject><subject>Myocardium - metabolism</subject><subject>Nuclear energy</subject><subject>Oxygen Consumption</subject><subject>Phosphates</subject><subject>Phosphocreatine - analysis</subject><subject>Phosphocreatine - metabolism</subject><subject>Phosphorus</subject><subject>Phosphorus (Chemical element)</subject><subject>Phosphorus metabolism</subject><subject>Respiration</subject><subject>Systole</subject><subject>Vertebrates: cardiovascular system</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s1v0zAUAPAIgUYZnLmAFCEEh9HNH7ETH0cF3aSOTgzGMXKcl9ZdYhfb4eO_x1ujbaBKVD7Y8vv5WfZ7SfIco0OMCT_ySoNRcEhzlHFaPEhGGAk2FgTRh8kIIcrHBcrZ4-SJ9yuEYkzQvWRv4KPk4jO0Mmhr0grCTwCTfrPuKpWmTs-X1q-XMkB6BkFWttVxqU0aljfTpf5h03OpoE7PZNfJVkuTnoB04WnyqJGth2fDvJ98_fjhy-RkPJtPTyfHs7HimQjjvAEuWd00goMggnNGOVAFAmGCBGFcZVWBm6zGFTQZobWoGKormuO8UohWdD95s8m7dvZ7Dz6UnfYK2lYasL0vc14QTljxX0g5jv_CSISv_oEr2zsTH1ESTBnJ0U22gw1ayBZKbRobnFQLMOBkaw00Om4fZ4TlTKCo323RcdTQabWFv_2LRxHgV1jI3vvy9OLTrnJ-uat8P91RFtPZfXmwTSrbtrCAMtZ5Mr-vjzZaOeu9g6ZcO91J97vEqLzu43Lo43JozHji5VCJvuqgvvV38ddDXHol28ZJo7S_ZUWsPcuuC_piw1Y-WHd3KxecxH77AzoN_74</recordid><startdate>19860530</startdate><enddate>19860530</enddate><creator>Balaban, R. 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S.</au><au>Kantor, H. L.</au><au>Katz, L. A.</au><au>Briggs, R. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation between Work and Phosphate Metabolite in the in Vivo Paced Mammalian Heart</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1986-05-30</date><risdate>1986</risdate><volume>232</volume><issue>4754</issue><spage>1121</spage><epage>1123</epage><pages>1121-1123</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Nuclear magnetic resonance (NMR) spectroscopy was used to monitor, on a beat-to-beat basis, the concentration of creatine phosphate and adenosine triphosphate during alterations in the work output of canine hearts in vivo. Over a wide range of rate-pressure products (5,000 to 25,000 mmHg/min), the relative amounts of creatine phosphate and adenosine triphosphate within the heart remained constant. The relative concentration of free adenosine diphosphate was calculated under the reasonable assumption that the creatine kinase--catalyzed reaction is near equilibrium in this tissue. The free concentration of adenosine diphosphate also did not change over this range of rate-pressure products. The data demonstrate that the concentration of these compounds is highly regulated in vivo and suggest that factors other than their concentration may be involved in the modulation of steady-state myocardial work output with oxygen consumption.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>3704638</pmid><doi>10.1126/science.3704638</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1986-05, Vol.232 (4754), p.1121-1123 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Adenosine Diphosphate - analysis Adenosine Diphosphate - metabolism Adenosine monophosphate Adenosine Triphosphate - analysis Adenosine Triphosphate - metabolism Adenylic acid Anatomy & physiology Biochemistry Biological and medical sciences Cardiovascular research Creatine Energy metabolism Fundamental and applied biological sciences. Psychology Heart Heart - physiology Heart Rate Magnetic Resonance Spectroscopy Magnets Medical research Metabolic regulation Metabolism Mitochondria Mitochondria, Heart - metabolism Myocardium - analysis Myocardium - metabolism Nuclear energy Oxygen Consumption Phosphates Phosphocreatine - analysis Phosphocreatine - metabolism Phosphorus Phosphorus (Chemical element) Phosphorus metabolism Respiration Systole Vertebrates: cardiovascular system |
| title | Relation between Work and Phosphate Metabolite in the in Vivo Paced Mammalian Heart |
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