The discriminative stimulus properties of cocaine and d-Amphetamine: The effects of three routes of administration
Five rhesus monkeys were trained to discriminate intramuscular cocaine (0.25 mg/kg, 10 min presession) from saline. In subsequent tests, intramuscular cocaine (0.03–0.5 mg/kg, 10 min presession) and intravenous cocaine (0.03–0.25 mg/kg, 10 min presession) controlled cocaine-appropriate responding in...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1986-03, Vol.24 (3), p.765-768 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | de la Garza, René Johanson, Chris E. |
| description | Five rhesus monkeys were trained to discriminate intramuscular cocaine (0.25 mg/kg, 10 min presession) from saline. In subsequent tests, intramuscular cocaine (0.03–0.5 mg/kg, 10 min presession) and intravenous cocaine (0.03–0.25 mg/kg, 10 min presession) controlled cocaine-appropriate responding in a dose-dependent manner and all monkeys tested reached training criterion (greater than 90% cocaine-appropriate responses) levels after the higher doses were tested.
d-Amphetamine (0.03–0.5 mg/kg) delivered intramuscularly (10 min presession) or intragastrically (60 min presession) also controlled cocaine-appropriate responding in a dose-dependent manner and, at the higher doses, all monkeys tested reached criterion. Regardless of route, cocaine and
d-amphetamine were similar in potency. Intragastric cocaine (0.5–16.0 mg/kg, 60 min presession) also controlled cocaine-appropriate responding at some dose in each monkey tested, but the drug was less potent. More importantly, the effects of IG cocaine were less systematic possibly due to uncontrolled pharmacokinetic factors. |
| doi_str_mv | 10.1016/0091-3057(86)90588-5 |
| format | Article |
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d-Amphetamine (0.03–0.5 mg/kg) delivered intramuscularly (10 min presession) or intragastrically (60 min presession) also controlled cocaine-appropriate responding in a dose-dependent manner and, at the higher doses, all monkeys tested reached criterion. Regardless of route, cocaine and
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d-Amphetamine (0.03–0.5 mg/kg) delivered intramuscularly (10 min presession) or intragastrically (60 min presession) also controlled cocaine-appropriate responding in a dose-dependent manner and, at the higher doses, all monkeys tested reached criterion. Regardless of route, cocaine and
d-amphetamine were similar in potency. Intragastric cocaine (0.5–16.0 mg/kg, 60 min presession) also controlled cocaine-appropriate responding at some dose in each monkey tested, but the drug was less potent. More importantly, the effects of IG cocaine were less systematic possibly due to uncontrolled pharmacokinetic factors.</description><subject>Animals</subject><subject>Cocaine</subject><subject>Cocaine - administration & dosage</subject><subject>Cocaine - pharmacology</subject><subject>d-amphetamine</subject><subject>Dextroamphetamine - administration & dosage</subject><subject>Dextroamphetamine - pharmacology</subject><subject>Discrimination (Psychology) - drug effects</subject><subject>Drug discrimination</subject><subject>Injections, Intramuscular</subject><subject>Injections, Intravenous</subject><subject>Intubation, Gastrointestinal</subject><subject>Macaca mulatta</subject><subject>Rhesus monkeys</subject><subject>Routes of administration</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1r3DAQxUVISLdJ_oMEdArtwc3I-rDcQyCEfsFCLslZyNKYVVjbW0kO9L-vvLvk2J7mML_3hnmPkGsGXxgwdQfQsoqDbD5p9bkFqXUlT8iK6YZXkjXNKVm9Ix_Ix5ReAUDUqjkn57wB3jK2IvF5g9SH5GIYwmhzeEOachjm7ZzoLk47jDlgolNP3eRsGJHa0VNfPQy7DWZbRPiVLibY9-jynsybiEjjNOeD0vqChZRj8Z_GS3LW223Cq-O8IC_fvz0__qzWTz9-PT6sK8dVm6taM8lE3zjpJOfghfBKCwlK17oHx0WnO2k70YHvOm4d72thVe2Ys2Bd1_ILcnvwLW_8njFlM5Q_cbu1I05zMk1xqqWq_wsyIVpgbAHFAXRxSilib3YlNhv_GAZm6cQsgZslcKOV2XdiZJHdHP3nbkD_LjqWUPb3hz2WNN4CRpNcwNGhD7FEavwU_n3gL8YHnIk</recordid><startdate>198603</startdate><enddate>198603</enddate><creator>de la Garza, René</creator><creator>Johanson, Chris E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>198603</creationdate><title>The discriminative stimulus properties of cocaine and d-Amphetamine: The effects of three routes of administration</title><author>de la Garza, René ; Johanson, Chris E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-281514f7c5c5330d44d684506828f0c34b8b5ab4b0dbb3ac3f24a62c1ca0acb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Cocaine</topic><topic>Cocaine - administration & dosage</topic><topic>Cocaine - pharmacology</topic><topic>d-amphetamine</topic><topic>Dextroamphetamine - administration & dosage</topic><topic>Dextroamphetamine - pharmacology</topic><topic>Discrimination (Psychology) - drug effects</topic><topic>Drug discrimination</topic><topic>Injections, Intramuscular</topic><topic>Injections, Intravenous</topic><topic>Intubation, Gastrointestinal</topic><topic>Macaca mulatta</topic><topic>Rhesus monkeys</topic><topic>Routes of administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de la Garza, René</creatorcontrib><creatorcontrib>Johanson, Chris E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de la Garza, René</au><au>Johanson, Chris E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The discriminative stimulus properties of cocaine and d-Amphetamine: The effects of three routes of administration</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1986-03</date><risdate>1986</risdate><volume>24</volume><issue>3</issue><spage>765</spage><epage>768</epage><pages>765-768</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>Five rhesus monkeys were trained to discriminate intramuscular cocaine (0.25 mg/kg, 10 min presession) from saline. In subsequent tests, intramuscular cocaine (0.03–0.5 mg/kg, 10 min presession) and intravenous cocaine (0.03–0.25 mg/kg, 10 min presession) controlled cocaine-appropriate responding in a dose-dependent manner and all monkeys tested reached training criterion (greater than 90% cocaine-appropriate responses) levels after the higher doses were tested.
d-Amphetamine (0.03–0.5 mg/kg) delivered intramuscularly (10 min presession) or intragastrically (60 min presession) also controlled cocaine-appropriate responding in a dose-dependent manner and, at the higher doses, all monkeys tested reached criterion. Regardless of route, cocaine and
d-amphetamine were similar in potency. Intragastric cocaine (0.5–16.0 mg/kg, 60 min presession) also controlled cocaine-appropriate responding at some dose in each monkey tested, but the drug was less potent. More importantly, the effects of IG cocaine were less systematic possibly due to uncontrolled pharmacokinetic factors.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3703911</pmid><doi>10.1016/0091-3057(86)90588-5</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 1986-03, Vol.24 (3), p.765-768 |
| issn | 0091-3057 1873-5177 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76822562 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Cocaine Cocaine - administration & dosage Cocaine - pharmacology d-amphetamine Dextroamphetamine - administration & dosage Dextroamphetamine - pharmacology Discrimination (Psychology) - drug effects Drug discrimination Injections, Intramuscular Injections, Intravenous Intubation, Gastrointestinal Macaca mulatta Rhesus monkeys Routes of administration |
| title | The discriminative stimulus properties of cocaine and d-Amphetamine: The effects of three routes of administration |
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