Action of a chronic administration of mescaline in dynamic behavioural situations
1. 1. The modifications of the rat behaviour caused by a chronic administration of mescaline were studied in two schedules of operant conditioning. 2. 2. In the “periodic conditioning” test, the schedule of reinforcement was changed from a fixed ratio to a fixed interval schedule. Mescaline (4 mg/kg...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 1986, Vol.10 (1), p.41-48 |
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| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
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| creator | Fundarò, Anna Molinengo, Luigi Cassone, Maria C. Orsetti, Marco |
| description | 1.
1. The modifications of the rat behaviour caused by a chronic administration of mescaline were studied in two schedules of operant conditioning.
2.
2. In the “periodic conditioning” test, the schedule of reinforcement was changed from a fixed ratio to a fixed interval schedule. Mescaline (4 mg/kg/day and 10 mg/kg/day) caused no modification of the ability of the rat to adapt its behaviour to the new experimental situation.
3.
3. In the “reversal test” the contingency for food delivery was switched from one lever, where responses were previously reinforced to the other lever where responses had no programmed consequences.
4.
4. A chronic administration of mescaline (4 mg/kg/day) caused a total incapacity of the rat to switch to the lever which became reinforced in the reversal trial.
5.
5. A chronic administration of 9 mg./kg/day of mescaline had an excitatory effect and the number of reinforced responses in the II and III reversals exceeded the unreinforced responses in a measure greater than in the controls. |
| doi_str_mv | 10.1016/0278-5846(86)90042-4 |
| format | Article |
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1. The modifications of the rat behaviour caused by a chronic administration of mescaline were studied in two schedules of operant conditioning.
2.
2. In the “periodic conditioning” test, the schedule of reinforcement was changed from a fixed ratio to a fixed interval schedule. Mescaline (4 mg/kg/day and 10 mg/kg/day) caused no modification of the ability of the rat to adapt its behaviour to the new experimental situation.
3.
3. In the “reversal test” the contingency for food delivery was switched from one lever, where responses were previously reinforced to the other lever where responses had no programmed consequences.
4.
4. A chronic administration of mescaline (4 mg/kg/day) caused a total incapacity of the rat to switch to the lever which became reinforced in the reversal trial.
5.
5. A chronic administration of 9 mg./kg/day of mescaline had an excitatory effect and the number of reinforced responses in the II and III reversals exceeded the unreinforced responses in a measure greater than in the controls.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/0278-5846(86)90042-4</identifier><identifier>PMID: 3704173</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Conditioning, Operant - drug effects ; fixed interval ; fixed ratio ; learning ; Male ; Medical sciences ; memory ; Memory - drug effects ; mescaline ; Mescaline - administration & dosage ; Mescaline - pharmacology ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychodysleptics: hallucinogen ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Inbred Strains ; Reinforcement Schedule ; Reversal Learning - drug effects ; reversal trials</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 1986, Vol.10 (1), p.41-48</ispartof><rights>1986</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-a641d21c04df5c76f1fd7097a8b468f422517d68596e51f8c0443d0baca980163</citedby><cites>FETCH-LOGICAL-c386t-a641d21c04df5c76f1fd7097a8b468f422517d68596e51f8c0443d0baca980163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0278-5846(86)90042-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8797056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3704173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fundarò, Anna</creatorcontrib><creatorcontrib>Molinengo, Luigi</creatorcontrib><creatorcontrib>Cassone, Maria C.</creatorcontrib><creatorcontrib>Orsetti, Marco</creatorcontrib><title>Action of a chronic administration of mescaline in dynamic behavioural situations</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>1.
1. The modifications of the rat behaviour caused by a chronic administration of mescaline were studied in two schedules of operant conditioning.
2.
2. In the “periodic conditioning” test, the schedule of reinforcement was changed from a fixed ratio to a fixed interval schedule. Mescaline (4 mg/kg/day and 10 mg/kg/day) caused no modification of the ability of the rat to adapt its behaviour to the new experimental situation.
3.
3. In the “reversal test” the contingency for food delivery was switched from one lever, where responses were previously reinforced to the other lever where responses had no programmed consequences.
4.
4. A chronic administration of mescaline (4 mg/kg/day) caused a total incapacity of the rat to switch to the lever which became reinforced in the reversal trial.
5.
5. A chronic administration of 9 mg./kg/day of mescaline had an excitatory effect and the number of reinforced responses in the II and III reversals exceeded the unreinforced responses in a measure greater than in the controls.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Conditioning, Operant - drug effects</subject><subject>fixed interval</subject><subject>fixed ratio</subject><subject>learning</subject><subject>Male</subject><subject>Medical sciences</subject><subject>memory</subject><subject>Memory - drug effects</subject><subject>mescaline</subject><subject>Mescaline - administration & dosage</subject><subject>Mescaline - pharmacology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychodysleptics: hallucinogen</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Reinforcement Schedule</subject><subject>Reversal Learning - drug effects</subject><subject>reversal trials</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMoc07_gUIvRPSimqRpkt4IY_gFAxH0OqT5YJE2nUk72L-33eouvTpw3uccznkAuETwHkFEHyBmPM05obec3hUQEpySIzBFvG8TjOgxmB6QU3AW4zeEEGUwm4BJxiBBLJuCj7lqXeOTxiYyUavQeKcSqWvnXWyD_MtqE5WsnDeJ84neeln3WGlWcuOaLsgqia7tdnQ8BydWVtFcjHUGvp6fPhev6fL95W0xX6Yq47RNJSVIY6Qg0TZXjFpkNYMFk7wklFuCcY6YpjwvqMmR5T1IMg1LqWTB-_ezGbjZ712H5qczsRW1i8pUlfSm6aJglGOcYdiDZA-q0MQYjBXr4GoZtgJBMZgUgyYxaBKcip1JQfqxq3F_V9ZGH4ZGdX1-PeZycGOD9MrFA8ZZwWA-nPm4x0zvYuNMEFE545XRLhjVCt24_-_4BdC7jvE</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Fundarò, Anna</creator><creator>Molinengo, Luigi</creator><creator>Cassone, Maria C.</creator><creator>Orsetti, Marco</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Action of a chronic administration of mescaline in dynamic behavioural situations</title><author>Fundarò, Anna ; Molinengo, Luigi ; Cassone, Maria C. ; Orsetti, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-a641d21c04df5c76f1fd7097a8b468f422517d68596e51f8c0443d0baca980163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Conditioning, Operant - drug effects</topic><topic>fixed interval</topic><topic>fixed ratio</topic><topic>learning</topic><topic>Male</topic><topic>Medical sciences</topic><topic>memory</topic><topic>Memory - drug effects</topic><topic>mescaline</topic><topic>Mescaline - administration & dosage</topic><topic>Mescaline - pharmacology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychodysleptics: hallucinogen</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Reinforcement Schedule</topic><topic>Reversal Learning - drug effects</topic><topic>reversal trials</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fundarò, Anna</creatorcontrib><creatorcontrib>Molinengo, Luigi</creatorcontrib><creatorcontrib>Cassone, Maria C.</creatorcontrib><creatorcontrib>Orsetti, Marco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fundarò, Anna</au><au>Molinengo, Luigi</au><au>Cassone, Maria C.</au><au>Orsetti, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Action of a chronic administration of mescaline in dynamic behavioural situations</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>1986</date><risdate>1986</risdate><volume>10</volume><issue>1</issue><spage>41</spage><epage>48</epage><pages>41-48</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>1.
1. The modifications of the rat behaviour caused by a chronic administration of mescaline were studied in two schedules of operant conditioning.
2.
2. In the “periodic conditioning” test, the schedule of reinforcement was changed from a fixed ratio to a fixed interval schedule. Mescaline (4 mg/kg/day and 10 mg/kg/day) caused no modification of the ability of the rat to adapt its behaviour to the new experimental situation.
3.
3. In the “reversal test” the contingency for food delivery was switched from one lever, where responses were previously reinforced to the other lever where responses had no programmed consequences.
4.
4. A chronic administration of mescaline (4 mg/kg/day) caused a total incapacity of the rat to switch to the lever which became reinforced in the reversal trial.
5.
5. A chronic administration of 9 mg./kg/day of mescaline had an excitatory effect and the number of reinforced responses in the II and III reversals exceeded the unreinforced responses in a measure greater than in the controls.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>3704173</pmid><doi>10.1016/0278-5846(86)90042-4</doi><tpages>8</tpages></addata></record> |
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| ispartof | Progress in neuro-psychopharmacology & biological psychiatry, 1986, Vol.10 (1), p.41-48 |
| issn | 0278-5846 1878-4216 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Biological and medical sciences Conditioning, Operant - drug effects fixed interval fixed ratio learning Male Medical sciences memory Memory - drug effects mescaline Mescaline - administration & dosage Mescaline - pharmacology Neuropharmacology Pharmacology. Drug treatments Psychodysleptics: hallucinogen Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Reinforcement Schedule Reversal Learning - drug effects reversal trials |
| title | Action of a chronic administration of mescaline in dynamic behavioural situations |
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