Ultrastructural evaluation of mid-dermal elastolysis
Mid‐dermal elastolysis is a well‐defined clinical and histopathologic entity manifested by fine wrinkling of the skin and a mid‐dermal loss of elastic fibers. Ulfrastructural and hislologic studies were performed in an attempt to better define the cause of the elastolytic process. Biopsy specimens f...
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| Veröffentlicht in: | Journal of cutaneous pathology 1994-06, Vol.21 (3), p.233-238 |
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| container_title | Journal of cutaneous pathology |
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| creator | Harmon, C. B. Su, W. P. D. Gagne, E. J. Fransway, A. F. Zelickson, B. D. |
| description | Mid‐dermal elastolysis is a well‐defined clinical and histopathologic entity manifested by fine wrinkling of the skin and a mid‐dermal loss of elastic fibers. Ulfrastructural and hislologic studies were performed in an attempt to better define the cause of the elastolytic process. Biopsy specimens from the lesions of 3 patients with mid‐dermal elasiolysis were studied at light and electron microscopic levels. Ultrastructural evidence of normal elastic fiber engulfment by activated macrophages was observed; however, some fields also demonstrated envelopment of abnormally degenerated elastic tissue. Although there are many potential causes of this degeneration, photodistribution of the lesions suggests that ultraviolet damage is a primary inciting factor. |
| doi_str_mv | 10.1111/j.1600-0560.1994.tb00266.x |
| format | Article |
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Although there are many potential causes of this degeneration, photodistribution of the lesions suggests that ultraviolet damage is a primary inciting factor.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Elastic Tissue - pathology</subject><subject>Elastic Tissue - ultrastructure</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Necrosis - pathology</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4363-d959ef6da4011868ae2d35b84b548672d1c509eb554b317df30012ab05334b723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Elastic Tissue - pathology</topic><topic>Elastic Tissue - ultrastructure</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Necrosis - pathology</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Skin - pathology</topic><topic>Skin - ultrastructure</topic><topic>Skin Diseases - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harmon, C. B.</creatorcontrib><creatorcontrib>Su, W. P. D.</creatorcontrib><creatorcontrib>Gagne, E. J.</creatorcontrib><creatorcontrib>Fransway, A. F.</creatorcontrib><creatorcontrib>Zelickson, B. D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harmon, C. B.</au><au>Su, W. P. D.</au><au>Gagne, E. J.</au><au>Fransway, A. F.</au><au>Zelickson, B. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrastructural evaluation of mid-dermal elastolysis</atitle><jtitle>Journal of cutaneous pathology</jtitle><addtitle>J Cutan Pathol</addtitle><date>1994-06</date><risdate>1994</risdate><volume>21</volume><issue>3</issue><spage>233</spage><epage>238</epage><pages>233-238</pages><issn>0303-6987</issn><eissn>1600-0560</eissn><coden>JCUPBN</coden><abstract>Mid‐dermal elastolysis is a well‐defined clinical and histopathologic entity manifested by fine wrinkling of the skin and a mid‐dermal loss of elastic fibers. Ulfrastructural and hislologic studies were performed in an attempt to better define the cause of the elastolytic process. Biopsy specimens from the lesions of 3 patients with mid‐dermal elasiolysis were studied at light and electron microscopic levels. Ultrastructural evidence of normal elastic fiber engulfment by activated macrophages was observed; however, some fields also demonstrated envelopment of abnormally degenerated elastic tissue. Although there are many potential causes of this degeneration, photodistribution of the lesions suggests that ultraviolet damage is a primary inciting factor.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7962825</pmid><doi>10.1111/j.1600-0560.1994.tb00266.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0303-6987 |
| ispartof | Journal of cutaneous pathology, 1994-06, Vol.21 (3), p.233-238 |
| issn | 0303-6987 1600-0560 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Biological and medical sciences Elastic Tissue - pathology Elastic Tissue - ultrastructure Female Humans Medical sciences Middle Aged Necrosis - pathology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin - pathology Skin - ultrastructure Skin Diseases - pathology |
| title | Ultrastructural evaluation of mid-dermal elastolysis |
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