The activation of prothrombin by the prothrombinase complex. The contribution of the substrate-membrane interaction to catalysis

The conversion of prothrombin to thrombin requires the cleavage of two peptide bonds and is catalyzed by the prothrombinase complex composed of factors Xa and Va assembled on a membrane surface. Presteady-state kinetic studies of the effects of membranes on the proteolytic reaction were undertaken u...

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Veröffentlicht in:	The Journal of biological chemistry 1994-11, Vol.269 (44), p.27441-27450
Hauptverfasser:	Walker, R K, Krishnaswamy, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalysis Cattle Enzyme Activation Enzyme Precursors - metabolism Factor Va - metabolism Factor Xa - metabolism In Vitro Techniques Kinetics Macromolecular Substances Phosphatidylcholines - metabolism Phosphatidylserines - metabolism Prothrombin - metabolism Thrombin - metabolism Thromboplastin - metabolism
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