Proteolytic processing and secretion of human beta-amyloid precursor protein in yeast. Evidence for a yeast secretase activity

Human beta-amyloid precursor protein (APP), the transmembrane precursor of the Alzheimer's disease beta-amyloid peptide, was expressed in the yeast Saccharomyces cerevisiae by fusion to prepro-alpha-factor. From analysis of protease-deficient yeast strains, the fusion protein underwent partial...

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Veröffentlicht in:	The Journal of biological chemistry 1994-11, Vol.269 (45), p.27799-27802
Hauptverfasser:	Zhang, H, Komano, H, Fuller, R S, Gandy, S E, Frail, D E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Amino Acid Sequence Amyloid beta-Protein Precursor - chemistry Amyloid beta-Protein Precursor - isolation & purification Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases Chromatography, Affinity Cloning, Molecular - methods Endopeptidases - metabolism Humans Molecular Sequence Data Peptide Fragments - chemistry Peptide Fragments - isolation & purification Plasmids Protein Processing, Post-Translational Recombinant Proteins - chemistry Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Saccharomyces cerevisiae - enzymology
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