Does the age-related change in CD44-defined T-cell subsets have functional significance for cytotoxic T lymphocyte generation?

CD44 or Pgp-1 is a transmembrane leukocyte adhesion-related glycoprotein which is often expressed in greater density on the membranes of memory T lymphocytes (CD44 hi) compared to naive T cells (CD44 lo). The proportion of Pgp hi or CD44 hi cells among T cells is increased with advancing age. We exa...

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Veröffentlicht in:	Immunology letters 1994-06, Vol.40 (3), p.251-258
Hauptverfasser:	Bloom, E.T., Mostowski, H.S., Horvath, J.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - immunology Animals Antibodies, Monoclonal Biological and medical sciences Carrier Proteins - immunology CD44 Cytotoxic T cell Cytotoxic T lymphocytes Female Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Hyaluronan Receptors Immunobiology Lymphocyte Culture Test, Mixed Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Male Memory T cell Mice Mice, Inbred BALB C Mice, Inbred C57BL Receptors, Cell Surface - immunology Receptors, Lymphocyte Homing - immunology T cell T-Lymphocyte Subsets - immunology T-Lymphocytes, Cytotoxic - immunology
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