Learning is improved by a soybean oil diet in rats
A semi-synthetic diet containing 20% polyunsaturated fat (soybean) oil was fed to young male hooded rats for 21 days. These animals exhibited improved performance on an environmentally-cued testing paradigm which is thought to reflect cognitive learning skills (i.e., Place Navigation Water Task). Ot...
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| Veröffentlicht in: | Life sciences (1973) 1986-05, Vol.38 (19), p.1789-1794 |
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| container_end_page | 1794 |
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| container_issue | 19 |
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| container_title | Life sciences (1973) |
| container_volume | 38 |
| creator | Coscina, Donald V. Yehuda, Shlomo Dixon, Lori M. Kish, Stephen J. Leprohon-Greenwood, Carol E. |
| description | A semi-synthetic diet containing 20% polyunsaturated fat (soybean) oil was fed to young male hooded rats for 21 days. These animals exhibited improved performance on an environmentally-cued testing paradigm which is thought to reflect cognitive learning skills (i.e., Place Navigation Water Task). Other rats fed the same base diet but containing 20% saturated fat (lard) showed no such improvement compared to chow-fed (4.5% mixed fat) controls. The animals fed soybean oil also exhibited a transient resistance to extinguish this learning. This improved learning could not be explained by changes in general motor activity, basal body temperature, energy consumption, body weight, or in the brain activity of choline acetyltransferase, the marker enzyme for cholinergic neurons. These findings constitute the first evidence that short-term variations in the quality of dietary fat can enhance mammalian learning. |
| doi_str_mv | 10.1016/0024-3205(86)90130-X |
| format | Article |
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These animals exhibited improved performance on an environmentally-cued testing paradigm which is thought to reflect cognitive learning skills (i.e., Place Navigation Water Task). Other rats fed the same base diet but containing 20% saturated fat (lard) showed no such improvement compared to chow-fed (4.5% mixed fat) controls. The animals fed soybean oil also exhibited a transient resistance to extinguish this learning. This improved learning could not be explained by changes in general motor activity, basal body temperature, energy consumption, body weight, or in the brain activity of choline acetyltransferase, the marker enzyme for cholinergic neurons. These findings constitute the first evidence that short-term variations in the quality of dietary fat can enhance mammalian learning.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(86)90130-X</identifier><identifier>PMID: 3702607</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>ACEITES VEGETALES ; Animal ; ANIMALES JOVENES ; Animals ; Biological and medical sciences ; Brain - enzymology ; CAPACIDAD MENTAL ; CAPACITE MENTALE ; Choline O-Acetyltransferase - metabolism ; Cognition - physiology ; Conditioning ; DIET ; DIETA ; Dietary Fats - physiology ; Fundamental and applied biological sciences. Psychology ; Glycine max ; HUILE VEGETALE ; JEUNE ANIMAL ; Learning - physiology ; Learning. Memory ; Male ; MENTAL ABILITY ; Oils - physiology ; PLANT OILS ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; RAT ; RATA ; RATS ; REGIME ALIMENTAIRE ; SOJA ; SOURCE FAT ; SOYBEANS ; YOUNG ANIMALS</subject><ispartof>Life sciences (1973), 1986-05, Vol.38 (19), p.1789-1794</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-e34ca9732f4a8822b035eb94f69be87f34288853c69a251ec8c6c7e1e864389f3</citedby><cites>FETCH-LOGICAL-c436t-e34ca9732f4a8822b035eb94f69be87f34288853c69a251ec8c6c7e1e864389f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(86)90130-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8044797$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3702607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coscina, Donald V.</creatorcontrib><creatorcontrib>Yehuda, Shlomo</creatorcontrib><creatorcontrib>Dixon, Lori M.</creatorcontrib><creatorcontrib>Kish, Stephen J.</creatorcontrib><creatorcontrib>Leprohon-Greenwood, Carol E.</creatorcontrib><title>Learning is improved by a soybean oil diet in rats</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>A semi-synthetic diet containing 20% polyunsaturated fat (soybean) oil was fed to young male hooded rats for 21 days. These animals exhibited improved performance on an environmentally-cued testing paradigm which is thought to reflect cognitive learning skills (i.e., Place Navigation Water Task). Other rats fed the same base diet but containing 20% saturated fat (lard) showed no such improvement compared to chow-fed (4.5% mixed fat) controls. The animals fed soybean oil also exhibited a transient resistance to extinguish this learning. This improved learning could not be explained by changes in general motor activity, basal body temperature, energy consumption, body weight, or in the brain activity of choline acetyltransferase, the marker enzyme for cholinergic neurons. These findings constitute the first evidence that short-term variations in the quality of dietary fat can enhance mammalian learning.</description><subject>ACEITES VEGETALES</subject><subject>Animal</subject><subject>ANIMALES JOVENES</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - enzymology</subject><subject>CAPACIDAD MENTAL</subject><subject>CAPACITE MENTALE</subject><subject>Choline O-Acetyltransferase - metabolism</subject><subject>Cognition - physiology</subject><subject>Conditioning</subject><subject>DIET</subject><subject>DIETA</subject><subject>Dietary Fats - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glycine max</subject><subject>HUILE VEGETALE</subject><subject>JEUNE ANIMAL</subject><subject>Learning - physiology</subject><subject>Learning. Memory</subject><subject>Male</subject><subject>MENTAL ABILITY</subject><subject>Oils - physiology</subject><subject>PLANT OILS</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>REGIME ALIMENTAIRE</subject><subject>SOJA</subject><subject>SOURCE FAT</subject><subject>SOYBEANS</subject><subject>YOUNG ANIMALS</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1L5EAQhhtZ0Vn1D4hCHxZZD9Hqj_THZUFkV4UBDyp4azqdirRkEu3OCPPvTZxhju6pDu9TxVsPIScMLhgwdQnAZSE4lL-NOrfABBTPO2TGjLYFKMF-kNkW2Sc_c34FgLLUYo_sCQ1cgZ4RPkefuti90JhpXLyl_gNrWq2op7lfVeg72seW1hEHGjua_JAPyW7j24xHm3lAnv79fby-Leb3N3fXV_MiSKGGAoUM3mrBG-mN4bwCUWJlZaNshUY3QnJjTCmCsp6XDIMJKmhkaJQUxjbigJyt746l3peYB7eIOWDb-g77ZXZaGSaFgP-CI2VKa9UIyjUYUp9zwsa9pbjwaeUYuMmpm4S5SZgzyn05dc_j2unm_rJaYL1d2kgc81-b3Ofg2yb5LsS8xQxIqe2EHa-xxvfOv6QReXoYnwWjpmp_1iGORj8iJpdDxC5gHROGwdV9_L7kJ9oQl-0</recordid><startdate>19860512</startdate><enddate>19860512</enddate><creator>Coscina, Donald V.</creator><creator>Yehuda, Shlomo</creator><creator>Dixon, Lori M.</creator><creator>Kish, Stephen J.</creator><creator>Leprohon-Greenwood, Carol E.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19860512</creationdate><title>Learning is improved by a soybean oil diet in rats</title><author>Coscina, Donald V. ; Yehuda, Shlomo ; Dixon, Lori M. ; Kish, Stephen J. ; Leprohon-Greenwood, Carol E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-e34ca9732f4a8822b035eb94f69be87f34288853c69a251ec8c6c7e1e864389f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>ACEITES VEGETALES</topic><topic>Animal</topic><topic>ANIMALES JOVENES</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - enzymology</topic><topic>CAPACIDAD MENTAL</topic><topic>CAPACITE MENTALE</topic><topic>Choline O-Acetyltransferase - metabolism</topic><topic>Cognition - physiology</topic><topic>Conditioning</topic><topic>DIET</topic><topic>DIETA</topic><topic>Dietary Fats - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glycine max</topic><topic>HUILE VEGETALE</topic><topic>JEUNE ANIMAL</topic><topic>Learning - physiology</topic><topic>Learning. Memory</topic><topic>Male</topic><topic>MENTAL ABILITY</topic><topic>Oils - physiology</topic><topic>PLANT OILS</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>REGIME ALIMENTAIRE</topic><topic>SOJA</topic><topic>SOURCE FAT</topic><topic>SOYBEANS</topic><topic>YOUNG ANIMALS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coscina, Donald V.</creatorcontrib><creatorcontrib>Yehuda, Shlomo</creatorcontrib><creatorcontrib>Dixon, Lori M.</creatorcontrib><creatorcontrib>Kish, Stephen J.</creatorcontrib><creatorcontrib>Leprohon-Greenwood, Carol E.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coscina, Donald V.</au><au>Yehuda, Shlomo</au><au>Dixon, Lori M.</au><au>Kish, Stephen J.</au><au>Leprohon-Greenwood, Carol E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Learning is improved by a soybean oil diet in rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1986-05-12</date><risdate>1986</risdate><volume>38</volume><issue>19</issue><spage>1789</spage><epage>1794</epage><pages>1789-1794</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>A semi-synthetic diet containing 20% polyunsaturated fat (soybean) oil was fed to young male hooded rats for 21 days. These animals exhibited improved performance on an environmentally-cued testing paradigm which is thought to reflect cognitive learning skills (i.e., Place Navigation Water Task). Other rats fed the same base diet but containing 20% saturated fat (lard) showed no such improvement compared to chow-fed (4.5% mixed fat) controls. The animals fed soybean oil also exhibited a transient resistance to extinguish this learning. This improved learning could not be explained by changes in general motor activity, basal body temperature, energy consumption, body weight, or in the brain activity of choline acetyltransferase, the marker enzyme for cholinergic neurons. These findings constitute the first evidence that short-term variations in the quality of dietary fat can enhance mammalian learning.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>3702607</pmid><doi>10.1016/0024-3205(86)90130-X</doi><tpages>6</tpages></addata></record> |
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| subjects | ACEITES VEGETALES Animal ANIMALES JOVENES Animals Biological and medical sciences Brain - enzymology CAPACIDAD MENTAL CAPACITE MENTALE Choline O-Acetyltransferase - metabolism Cognition - physiology Conditioning DIET DIETA Dietary Fats - physiology Fundamental and applied biological sciences. Psychology Glycine max HUILE VEGETALE JEUNE ANIMAL Learning - physiology Learning. Memory Male MENTAL ABILITY Oils - physiology PLANT OILS Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology RAT RATA RATS REGIME ALIMENTAIRE SOJA SOURCE FAT SOYBEANS YOUNG ANIMALS |
| title | Learning is improved by a soybean oil diet in rats |
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